Administrative Core

行政核心--摘要 建议的获得性治疗抵抗和铁(ARTI)中心的重点是铁性下垂的作用 对放射治疗的获得性抵抗力。放射疗法被用于治疗大约50%的癌症 是肺癌和食道癌患者的标准护理治疗。阿尔蒂中心将 专注于这些癌症类型，包括三个研究项目。项目1将专注于确定 铁下垂在放射治疗获得性抵抗中的作用机制及FINS的检测 放射增敏剂。项目2的重点是确定缺氧是否会导致对铁性下垂的抵抗。 促进获得性肿瘤对放射治疗的抵抗以及FINS是否使缺氧的肿瘤细胞重新增敏 接受放射治疗。项目3将侧重于了解基因组和微环境因素的作用 食管腺癌中铁下垂对放化疗的获得性耐药。三项研究 项目将由一个共享的分子成像核心(MIC)提供支持，该核心将提供成像工具和 用于测量肿瘤生长、评估克服获得性辐射抵抗能力的分析 联合治疗(例如，FINS与放射治疗或免疫治疗)，确定肿瘤内低氧 并评估髓系细胞的扩张在提高铁性下垂对化疗放射治疗的抵抗力方面的作用。 为支持MIC和这三个项目，将设立行政核心(AC)作为 ARTI中心基础设施，将支持、协调和促进旨在实现和 评估项目和核心的里程碑。协调委员会将建立和保持接触，并 AIM 1中ARTI中心和ARTnet成员以及项目官员之间的沟通。在AIM 2中，AC将 促进ARTI中心评估，支持及时和高质量的开发和进度提交 报告，并保持适当和透明的资金管理。咨询委员会将制定和实施一项 AIM 3中试点项目和跨网络项目的内部征集和优先顺序确定流程。在AIM 4中，AC 将作为建立网站和管理数据、材料、资源、冲突的中央基础设施 解决，以及技术和工具的知识产权问题。多重首席调查员 Arti中心(MPI)的甘博义博士和阿尔伯特·孔博士将担任AC联席领导人。在……下面 在他们的领导下，咨询委员会将能够利用机构和部门资源；建立和维持 艺术中心咨询委员会；鼓励初级教师、实习生和学生在 癌症研究；促进整个Artnet的合作；并确保遵守Artnet的治理 以及资源和数据共享策略。总体而言，空调将是阿尔蒂中心 与其他Artnet中心以及其他国家癌症研究所资助的项目和倡议相结合。

ADMINISTRATIVE CORE – SUMMARY The proposed Acquired Resistance to Therapy and Iron (ARTI) Center is focused on the role of ferroptosis in acquired resistance to radiation therapy. Radiation therapy is used to treat approximately 50% of cancer patients and is standard of care treatment for lung cancer and esophageal cancer patients. The ARTI Center will focus on these cancer types and comprise three research projects. Project 1 will focus on identifying the mechanisms of ferroptosis in acquired resistance to radiation therapy and testing ferroptosis inducers (FINs) as radiosensitizers. Project 2 will focus on determining whether hypoxia-induced resistance to ferroptosis contributes to acquired tumor resistance to radiation therapy and whether FINs re-sensitize hypoxic tumor cells to radiation treatment. Project 3 will focus on understanding the role of genomic and microenvironment factors in acquired resistance to ferroptosis to chemoradiation in esophageal adenocarcinoma. The three research projects will be supported by one shared Molecular Imaging Core (MIC), which will provide imaging tools and analyses for measuring tumor growth, assessing the ability to overcome acquired radiation resistance using combination therapies (e.g., FINs with radiation therapy or immunotherapy), identifying intratumoral hypoxic regions, and evaluating myeloid cell expansion in conferring ferroptosis resistance to chemoradiation therapy. To support the MIC and these three projects, the Administrative Core (AC) will be established as part of the ARTI Center infrastructure that will support, coordinate, and facilitate all activities aimed at achieving and evaluating milestones across the projects and core. The AC will establish and maintain engagement and communication among ARTI Center and ARTNet members and program officials in Aim 1. In Aim 2, the AC will facilitate ARTI Center evaluation, support the timely and quality development and submission of progress reports, and maintain proper and transparent stewardship of funds. The AC will develop and implement an internal solicitation and prioritization process for Pilot and Trans-Network Projects in Aim 3. In Aim 4, the AC will serve as the central infrastructure to build a website and manage data, materials, resources, conflict resolution, and issues of intellectual property for technologies and tools. The multiple Principal Investigators (mPIs) of the ARTI Center, Boyi Gan, PhD and Albert Koong, MD, PhD, will serve as AC Co-Leaders. Under their leadership, the AC will be able to leverage institutional and divisional resources; to establish and maintain an ARTI Center Advisory Committee; to encourage the development of junior faculty, trainees, and students in cancer research; to promote collaborations across ARTNet; and to ensure abidance by the ARTNet governance and resource and data sharing policies. Overall, the AC will be the central juncture for the ARTI Center to integrate with other ARTNet centers as well as other National Cancer Institute-funded programs and initiatives.