Human Pathogens and Coastal Ocean Processes

人类病原体和沿海海洋过程

• 批准号: 7565987
• 负责人: REBECCA J GAST
• 金额: $ 8.61万
• 依托单位: WOODS HOLE OCEANOGRAPHIC INSTITUTION
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7565987
• 关键词: Acanthamoeba; Affect; Amoeba genus; Area; Bacteria; Beds; Biological; Boat; Characteristics; Chemicals; Condition; Coupled; Cryptosporidium; Data; Disease Outbreaks; Endemic Diseases; Environment; Eutrophication; Fishes; Fresh Water; Giardia; Health; Human; Human Activities; In Situ Hybridization; Infection; Legionella pneumophila; Marines; Massachusetts; Measurement; Methodology; Methods; Modeling; Molecular; Monitor; Naegleria; Oceans; Output; Parasites; Phase; Pollution; Polymerase Chain Reaction; Population; Power Plants; Prevalence; Process; Recreation; Reporting; Research; Risk; Rivers; Seawater; Sewage; Shellfish; Site; Source; Structure; Surveys; System; Testing; Vibrio; Vibrio parahaemolyticus; Vibrio vulnificus; Water; base; boating; human disease; member; microbial; microbial community; novel; pathogen; pathogenic bacteria; predictive modeling; water quality

Some human pathogens are natural members of the marine microbial community (e.g Vibrio species), but many others, such as the protist Giardia, are potentially introduced into seawater from sewage input and terrestrial runoff. Despite the potential for their impact on human health, relatively little is known about the occurrence, much less the prevalence and distribution, of traditionally non-marine human pathogens. The survival and persistence of various pathogens is most certainly influenced by environmental conditions, and the contamination of coastal and estuarine areas through freshwater runoff, sewage and thermal pollution have the potential to alter local environmental conditions. Studies that examine pathogen presence and persistence need to be coupled with predictive models in order to begin to determine where and when the risks of potential infection, or simply the presence of pathogens, are highest. Our project aims are to use molecular methodology to determine the distribution and abundances of the human pathogens (including Giardia, Cryptosporidium, Acanthamoeba, Naegleria, Vibrio and LegioneIla), determine whether naturally occurring marine amoebae can serve as reservoirs for pathogenic bacteria, and look for evidence of natural occurrence of these associations in the anthropogenically impacted estuarine environment of Mount Hope Bay, MA. Data will be collected over spatially and temporally relevant scales (multiple sites, multiple years). Information on the physico-chemical characteristics will be correlated with biological distribution and persistence information for use in evaluating a water quality/eutrophication model for the bay that could be used to predict where and when pathogens could be found.

一些人类病原体是海洋微生物群落的天然成员（例如弧菌种），但许多其他病原体，如原生贾第鞭毛虫，可能是从污水输入和陆地径流引入海水的。尽管它们可能对人类健康产生影响，但对传统上非海洋人类病原体的发生情况知之甚少，更不用说流行和分布情况了。各种病原体的生存和持续存在肯定受到环境条件的影响，通过淡水径流、污水和热污染对沿海和河口地区的污染有可能改变当地的环境条件。检查病原体存在和持久性的研究需要与预测模型相结合，以便开始确定何时何地发生