黑人乳腺癌易感基因的复制研究-猫眼课题宝

黑人乳腺癌易感基因的复制研究

批准号：

7743707

负责人：

Dezheng Huo

金额：

$40.0万

依托单位：

UNIVERSITY OF CHICAGO

依托单位国家：

美国

项目类别：

财政年份：

2009

资助国家：

美国

项目状态：

已结题

起止时间：

2009-09-21 至 2010-08-31

来源：

https://reporter.nih.gov/project-details/7743707

关键词：

10q21 16q12 2q35 6q22 Affect Africa African African American Age Barbados Breast Breast Cancer Risk Factor Breast Cancer Treatment Cancer-Predisposing Gene Case-Control Studies Caucasians Caucasoid Race Chicago Chromosomes Clinical DNA Data Databases Development Disease Early Diagnosis Enrollment Environmental Exposure Environmental Risk Factor Ethnic group European FGFR2 gene Funding Future Genes Genetic Genetic Risk Genome Genomics Genotype Health Services Accessibility Incidence Individual Joints Lead Life Linkage Disequilibrium Logistic Regressions Malignant Neoplasms Maps Modification Mutation National Human Genome Research Institute Native-Born Negative Finding Nigeria Odds Ratio Pattern Play Population Population Attributable Risks Population Control Predisposition Prevalence Prevention Prevention strategy Procedures Recruitment Activity Reproduction spores Risk Risk Assessment Risk Factors Role Sampling Single Nucleotide Polymorphism Staging Stratification Surrogate Markers Testing Translating Update Variant Woman base breast cancer family registry cancer risk clinically significant cohort early onset epidemiologic data experience gene environment interaction genetic epidemiology genetic risk factor genetic variant genome wide association study health disparity innovation interest malignant breast neoplasm minority health mortality novel racial and ethnic

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DESCRIPTION (provided by applicant): African Americans and Africans experience a disproportionate burden of aggressive breast cancer in comparison to all other racial/ethnic groups for reasons that remain unknown and understudied. The paucity of data on the genetic epidemiology of breast cancer for women of African ancestry hinders the development of innovative prevention to reduce health disparities. Because common genetic variants with potential large population attributable risk may play a role in breast cancer development and progression for women of African ancestry in a way different from women of European ancestry, we propose to replicate 5 novel breast cancer susceptibility loci (involving 11 genes) previously identified in genome-wide association studies in a well-characterized cohort of about 2200 breast cancer cases and 2300 controls, all of African ancestry. DNA samples and epidemiologic data for this large study have been collected through Nigerian Breast Cancer Study (Africans), Barbados National Cancer Study (African Barbadians), and the Chicago Breast SPORE and the Breast Cancer Family Registry (African Americans). We will employ the replication plus fine-mapping strategy to genotype exactly same SNPs identified in original studies and a panel of tagSNPs and putative functional variants in these 5 genomic regions. For African Americans, ancestry informative markers will also be genotyped to control for population stratification. Multiple imputation procedure will be used to impute variants that are not genotyped. Logistic regressions will be used to test the associations and calculate odd ratios. Furthermore, we will examine gene-environment interaction as there are sharp contrasts in epidemiologic risk factors among the three populations of African ancestry. This study will advance understanding the genetic risk factors for breast cancer in women of African descent and will be invaluable in developing novel prevention strategies in the future.

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