Targeting a Novel Phosphoinositide Signaling Pathway for Cancer Therapy
针对癌症治疗的新型磷酸肌醇信号通路
基本信息
- 批准号:7633803
- 负责人:
- 金额:$ 24.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-06-04 至 2011-05-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAmericanApoptoticArchitectureCancerousCell DeathCell ProliferationCell SurvivalCell membraneCellsDataDevelopmentEndocrineEndoplasmic ReticulumEngineeringEquipment and SuppliesFamilyFundingGolgi ApparatusGolgi TargetingGrowth FactorGrowth Factor ReceptorsIGF-1 Signaling PathwayMalignant NeoplasmsMethodsNormal CellOccupationsPathway interactionsPharmaceutical PreparationsPhosphatidylinositolsPlatelet-Derived Growth FactorPlayProtein BindingRecoveryRoleSignal PathwaySignal TransductionSystemTestingTherapeuticVesicleautocrinecancer cellcancer therapycell growthcell transformationchemotherapeutic agentclinical applicationendoplasmic reticulum stressnew therapeutic targetnovelnovel therapeuticsparacrineprotein misfoldingresearch studytooltraffickingtreatment strategy
项目摘要
Dramatic advances in cancer treatment will depend on identifying new targets for therapeutics. Here we propose as a candidate target a novel phosphoinositide signaling pathway that we have discovered. We have identified a pathway involving the phosphoinositide PtdIns(4)P and a new protein that binds to it which
we have called PI4P-BP. We have shown that this pathway is required for normal Golgi architecture and function. Cancer cells often require autocrine, paracrine, or endocrine growth factor signaling for continued proliferation and survival. Since trafficking of growth factors and growth factor receptors requires intact Golgi function, interference with the Golgi is expected to interfere with cancer proliferation and survival. We have devised methods to inducibly interfere with the PtdIns(4)P/PI4P-BP pathway. We propose experiments to determine the effect of interference with the PtdIns(4)P/PI4P-BP pathway on growth factor signaling and thus whether it will be worthwhile to develop this novel therapeutic strategy further toward its clinical application.
癌症治疗的巨大进展将取决于确定新的治疗靶点。在这里,我们建议将我们发现的新型磷酸肌醇信号通路作为候选靶点。我们已经确定了一条涉及磷酸肌醇 PtdIns(4)P 的途径以及与其结合的新蛋白质,
我们称之为PI4P-BP。我们已经证明,这条通路是正常高尔基体结构和功能所必需的。癌细胞通常需要自分泌、旁分泌或内分泌生长因子信号传导才能持续增殖和存活。由于生长因子和生长因子受体的运输需要完整的高尔基体功能,因此干扰高尔基体预计会干扰癌症的增殖和存活。我们设计了诱导干扰 PtdIns(4)P/PI4P-BP 途径的方法。我们提出实验来确定干扰 PtdIns(4)P/PI4P-BP 通路对生长因子信号传导的影响,从而确定是否值得进一步开发这种新型治疗策略以实现其临床应用。
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
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{{ truncateString('SETH J FIELD', 18)}}的其他基金
Mechanism of Action of a Novel Golgi-Targeted Anti-Cancer Agent
新型高尔基体靶向抗癌剂的作用机制
- 批准号:
10407638 - 财政年份:2020
- 资助金额:
$ 24.89万 - 项目类别:
Mechanism of Action of a Novel Golgi-Targeted Anti-Cancer Agent
新型高尔基体靶向抗癌剂的作用机制
- 批准号:
10631058 - 财政年份:2020
- 资助金额:
$ 24.89万 - 项目类别:
Mechanism of Action of a Novel Golgi-Targeted Anti-Cancer Agent
新型高尔基体靶向抗癌剂的作用机制
- 批准号:
10247801 - 财政年份:2020
- 资助金额:
$ 24.89万 - 项目类别:
High Throughput Screen to Identify Inhibitors of the Golgi GOLPH3 Pathway
用于鉴定高尔基体 GOLPH3 通路抑制剂的高通量筛选
- 批准号:
9006373 - 财政年份:2016
- 资助金额:
$ 24.89万 - 项目类别:
GOLPH3 Pathway Regulation of Golgi Structure and Function
高尔基体结构和功能的 GOLPH3 通路调节
- 批准号:
9152791 - 财政年份:2016
- 资助金额:
$ 24.89万 - 项目类别:
GOLPH3 Pathway Regulation of Golgi Structure and Function
高尔基体结构和功能的 GOLPH3 通路调节
- 批准号:
9333407 - 财政年份:2016
- 资助金额:
$ 24.89万 - 项目类别:
GOLPH3 Pathway Regulation of Golgi Structure and Function
高尔基体结构和功能的 GOLPH3 通路调节
- 批准号:
9545008 - 财政年份:2016
- 资助金额:
$ 24.89万 - 项目类别:
PI-3-Kinase Signaling over Physiologic Time-Scales/Response to Insulin or IGF-1
PI-3-激酶信号转导在生理时间尺度上/对胰岛素或 IGF-1 的反应
- 批准号:
7245126 - 财政年份:2006
- 资助金额:
$ 24.89万 - 项目类别:
PI-3-Kinase Signaling over Physiologic Time-Scales/Response to Insulin or IGF-1
PI-3-激酶信号转导在生理时间尺度上/对胰岛素或 IGF-1 的反应
- 批准号:
7127535 - 财政年份:2006
- 资助金额:
$ 24.89万 - 项目类别:
PI-3-kinase mediated signaling by insulin and IGF-1
PI-3-激酶介导的胰岛素和 IGF-1 信号转导
- 批准号:
7269328 - 财政年份:2003
- 资助金额:
$ 24.89万 - 项目类别:
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