Training in Mechanisms of Parasitism

寄生机制培训

• 批准号: 7637429
• 负责人: John E Donelson
• 金额: $ 24.08万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7637429
• 关键词: Training; parasitism

DESCRIPTION (provided by applicant): "Parasitism" refers to the successful invasion of and survival within a host by a microbe. Microbes use various strategies to evade or suppress host defenses and successfully parasitize a mammalian host. This application is based upon the hypothesis that different parasitic organisms face similar obstacles, and therefore design related strategies to survive in the mammalian host environment. Progress in microbial and host genomics, proteomics, and imaging technology has greatly enhanced the tools available to scientists in addressing both sides of the equation, i.e., the survival mechanisms of the microbe and the defense strategies of the host. Consequently, scientists studying protozoal, bacterial, and viral pathogens can learn from one another. This Mechanisms of Parasitism training program represents a union between the fields of parasitology, bacterial pathogenesis, viral pathogenesis and immunology into a single program. Its goal is to enhance collaborative research and training among laboratories at the University of Iowa specializing in these disciplines, and in the process provide a rich environment for the development of trainees. In the nine years since its beginning, the Mechanisms of Parasitism program has funded 32 trainees, conducted annual research retreats, continuously held a weekly Journal/Research Club meeting, sponsored outside speakers, and provided centralized computerized equipment to trainees. In this application we propose to: (1) increase support to 4 predoctoral and 3 postdoctoral trainees from the current 3 predoctoral and 3 postdoctoral trainees; (2) expand our core facilities to a real-time PCR machine, maintained by the DNA core of the University of Iowa; (3) initiate a summer seminar series in which faculty with expertise in digital imaging, bioinformatics, microarrays, proteomics, and genome analysis work directly with trainees; (4) initiate trainee-invited speakers; and (5) institute an outside and internal evaluation process. Our goal is to continue to maintain a productive environment for exchange of creative ideas among faculty and trainees working on different aspects of microbial infection.

描述（由申请人提供）：“寄生”是指微生物成功侵入宿主并在宿主内存活。微生物使用各种策略来逃避或抑制宿主防御并成功寄生于哺乳动物宿主。该应用基于以下假设：不同的寄生生物体面临类似的障碍，因此设计相关的策略以在哺乳动物宿主环境中生存。微生物和宿主基因组学、蛋白质组学和成像技术的进展大大增强了科学家在解决等式两边时可用的工具，即，微生物的生存机制和宿主的防御策略。因此，研究原生动物、细菌和病毒病原体的科学家可以相互学习。这个寄生虫学培训计划的机制代表了寄生虫学，细菌发病机理，病毒发病机理和免疫学领域之间的联盟成为一个单一的程序。其目标是加强爱荷华州大学专门从事这些学科的实验室之间的合作研究和培训，并在此过程中为受训人员的发展提供丰富的环境。在其开始以来的九年中，寄生虫机制方案资助了32名学员，每年进行研究务虚会，连续举行每周一次的期刊/研究俱乐部会议，赞助外部演讲者，并向学员提供中央计算机设备。在本申请中，我们建议：（1）从目前的3名博士前和3名博士后培训生增加到4名博士前和3名博士后培训生;（2）将我们的核心设施扩展到实时PCR仪，由爱荷华州大学的DNA核心维护;（3）启动暑期系列研讨会，在数字成像，生物信息学，微阵列，蛋白质组学和基因组分析方面具有专业知识的教师直接与学员合作;（4）邀请受训者发言;（5）建立外部和内部评估程序。我们的目标是继续保持一个富有成效的环境，以便在微生物感染的不同方面工作的教师和学员之间交流创造性的想法。