Integrative Systems Biology Core

综合系统生物学核心

• 批准号: 10713944
• 负责人: Thomas Louis LaFramboise
• 金额: $ 32.69万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10713944
• 关键词: Barrett Esophagus; Barrett' s carcinogenesis; Cells; Clinical; Collaborations; Communication; Complex; Comprehensive Cancer Center; Computer Analysis; Data; Data Analyses; Data Set; Database Management Systems; Databases; Development; Diagnosis; Disease; Duke Comprehensive Cancer Center; Dysplasia; Early Diagnosis; Ensure; Environmental Risk Factor; Esophageal injury; Etiology; Experimental Designs; Faculty; Formulation; Foundations; Genes; Goals; Grant; Human Resources; Information Dissemination; Infrastructure; Inherited; Injury; Institution; Investments; Leadership; Malignant neoplasm of esophagus; Manuscripts; Metaplasia; Methods; Molecular; Molecular Profiling; Multiomic Data; Pathway interactions; Physiology; Positioning Attribute; Pre-Clinical Model; Predisposition; Prevention; Program Research Project Grants; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Resources; Secure; Specialized Program of Research Excellence; Systems Biology; Testing; Tissue Model; Tissues; Training Programs; Universities; Writing; analytical method; cancer epidemiology; cancer prevention; carcinogenesis; computer infrastructure; data management; data sharing; design; experimental study; gastrointestinal; genetic epidemiology; genome-wide; injury and repair; innovation; large scale data; medical schools; meetings; multiple omics; novel; programs; repaired; skills; wound healing

PROJECT SUMMARY/ABSTRACT The Integrative Systems Biology Core will interact with all investigators to develop and apply appropriate analysis methods and designs to most efficiently achieve project goals. We will ensure that the experimental data is analyzed appropriately to test the hypotheses relevant to each project. In addition, the Integrative Systems Biology Core will provide infrastructure and oversight for secure management of all study data, working closely with the Bioreagents & Resource Core to facilitate accuracy and completeness of datasets for all projects and investigators. Our specific aims are: (1) To integrate cutting-edge analytic approaches in the design, analysis, and interpretation of experimental studies across projects in our program; and (2) To provide secure and accessible database systems and computational infrastructure to facilitate reliable and reproducible analyses conducted by all program investigators. The Integrative Systems Biology Core leverages faculty and resources in the Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine and the Duke Molecular Physiology Institute. Dr. Thomas LaFramboise will direct the Core, with Dr. Simon Gregory as co-director. The Integrative Systems Biology Core will serve as a centralized resource for all personnel, including the leaders of the three research projects and the Bioreagents & Resource Core. The Core will assist investigators with all facets of design, computational analysis and interpretation. Established as well as novel tailored analytic methods are available to promote scientific discovery for investigators within the Core. Core personnel will interact with investigators in all stages of research, from data management, data analysis, interpretation, writing scientific manuscripts and grants, to dissemination of results. The Core will also facilitate access to secure and accessible database systems, facilitating analysis, discovery and collaboration. The Core will assist all investigators with development, management and reliability of their project data and will also integrate information across databases, such as incorporating clinical and experimental data with biospecimen data as provided by the Bioreagents & Resource Core. The Integrative Systems Biology Core will provide a natural foundation for cross-pollination among the projects and Cores, the Core personnel collaborating with all project investigators and Core directors.

项目总结/摘要 综合系统生物学核心将与所有研究人员互动，以开发和应用适当的分析 方法和设计，以最有效地实现项目目标。我们将确保实验数据 适当地进行分析，以检验与每个项目相关的假设。此外，综合系统 生物核心将提供基础设施和监督，以安全管理所有研究数据， 与生物试剂和资源核心，以促进所有项目数据集的准确性和完整性， investigators.我们的具体目标是：（1）在设计，分析， 和解释我们计划中的各个项目的实验研究;以及（2）提供安全和 可访问的数据库系统和计算基础设施，以促进可靠和可重复的分析 由所有项目调查员进行。综合系统生物学核心利用教师和资源 在凯斯西储大学医学院和凯斯综合癌症中心， 杜克分子生理学研究所。托马斯·拉弗兰博伊斯博士将与西蒙·格雷戈里博士一起指挥核心 共同导演综合系统生物学核心将作为所有人员的集中资源， 包括三个研究项目的负责人和生物试剂与资源核心。核心会协助 研究人员与设计，计算分析和解释的各个方面。既确定又新颖 定制的分析方法可用于促进核心内的研究人员的科学发现。核心 工作人员将在研究的所有阶段与研究人员互动，从数据管理，数据分析， 从口译、撰写科学手稿和赠款到传播成果。核心也将 促进访问安全和可访问的数据库系统，促进分析、发现和 协作核心小组将协助所有研究者进行项目的开发、管理和可靠性 数据，并将整合跨数据库的信息，如纳入临床和实验数据， 与生物试剂和资源核心提供的生物标本数据。综合系统生物学核心 将为项目和核心人员之间的交叉授粉提供自然基础 与所有项目调查员和核心主管合作。