Core 2: Biostatistics and Informatics Core

项目摘要/摘要 Case GI孢子生物统计和信息学核心将与所有孢子调查人员互动，以开发和 应用适当的分析方法、研究设计和安全数据库来最有效地实现项目 目标。我们将与调查人员密切合作，确保研究问题导致实验 可量化的目标和可检验的假设。此外，案例GI孢子生物统计学和信息学核心 将为所有研究数据的安全管理提供基础设施和监督，并与 Biosecimen核心，以促进所有项目和调查人员数据集的准确性和完整性。我们的 具体目标是：(1)为病原菌孢子调查员提供设计、进行、分析和 报告病原菌孢子研究结果；(2)提供安全和可访问的数据库系统 为所有病例GI孢子调查人员提供可靠和可重复性的有效结果。生物统计学 Informatics Core利用Case综合癌症中心的师资和资源 西部储备大学(CWRU)医学院和计算生物学研究所 CWRU。吉尔·巴恩霍尔茨-斯隆博士和乔纳森·海恩斯博士将共同执导《核心》。生物统计学和 Informatics Core将作为所有参与GI孢子案件的调查人员的集中资源， 包括4个翻译研究项目、发展研究计划(DRP)的负责人 研究人员、职业提升计划(CEP)调查人员和Biosecimen Core的负责人。这个 CORE将协助调查人员进行统计设计、分析和解释的所有方面。已建立为 以及新的量身定做的分析方法，以促进科学发现胃肠道癌症在 核心。核心人员将在研究的所有阶段与孢子调查人员互动，从制定 研究问题，通过实验设计、数据管理、数据分析(包括结果 分析)、口译、撰写科学手稿和赠款，以及传播成果。核心意志 还便利访问安全和可访问的数据库系统，以协助统计 分析、发现和合作。核心将协助所有调查人员进行开发、管理和 他们的项目数据的可靠性，并将跨数据库集成信息，例如整合临床 以及由Biosecimen Core提供的生物谱数据的实验数据。生物统计学和 信息学核心将为项目和核心之间的异花授粉提供一个天然的基础， 核心人员与所有项目调查员和核心总监合作。

PROJECT SUMMARY/ABSTRACT The Case GI SPORE Biostatistics and Informatics Core will interact with all SPORE investigators to develop and apply appropriate analysis methods, study designs and secure databases to most efficiently achieve project goals. We will work closely with investigators to ensure that research questions lead to experiments with quantifiable goals and testable hypotheses. In addition the Case GI SPORE Biostatistics and Informatics Core will provide infrastructure and oversight for secure management of all study data, working closely with the Biospecimen Core to facilitate accuracy and completeness of datasets for all projects and investigators. Our specific aims are: (1) To provide support to Case GI SPORE investigators in the design, conduct, analysis and reporting of results from Case GI SPORE studies and (2) To provide secure and accessible database systems to facilitate reliable and reproducible impactful results for all Case GI SPORE investigators. The Biostatistics and Informatics Core leverages faculty and resources in the Case Comprehensive Cancer Center, Case Western Reserve University (CWRU) School of Medicine and the Institute for Computational Biology (ICB) at CWRU. Drs. Jill Barnholtz-Sloan and Jonathan Haines will co-direct the Core. The Biostatistics and Informatics Core will serve as a centralized resource for all investigators involved in the Case GI SPORE, including the leaders of the 4 translational research projects, Developmental Research Program (DRP) investigators, Career Enhancement Program (CEP) investigators and leaders of the Biospecimen Core. The Core will assist investigators with all facets of statistical design, analysis and interpretation. Established as well as novel tailored analytic methods are available to promote scientific discovery for GI cancers within the Core. Core personnel will interact with SPORE investigators in all stages of research, from the formulation of the research questions, through experimental design, data management, data analysis (including outcomes analysis), interpretation, writing scientific manuscripts and grants, to dissemination of results. The Core will also facilitate access to secure and accessible database systems in order to assist with statistical analysis, discovery and collaboration. The Core will assist all investigators with development, management and reliability of their project data and will also integrate information across databases, such as incorporating clinical and experimental data with biospecimen data as provided by the Biospecimen Core. The Biostatistics and Informatics Core will provide a natural foundation for cross-pollination among the projects and Cores, the Core personnel collaborating with all project investigators and Core directors.