Core 2: Biostatistics and Informatics Core

核心2：生物统计学和信息学核心

• 批准号: 10227751
• 负责人: Thomas Louis LaFramboise
• 金额: $ 23.25万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-14 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10227751
• 关键词: Bioinformatics; Biometry; Biostatistics Core; Chairperson; Clinic; Clinical; Clinical Research; Collaborations; Comprehensive Cancer Center; Computational Biology; Core Facility; Data; Data Analyses; Data Security; Data Set; Database Management Systems; Databases; Development; Ensure; Environment; Epidemiology; Experimental Designs; Faculty; Formulation; Foundations; Goals; Grant; Hospitals; Human Resources; Informatics; Information Dissemination; Infrastructure; Institutes; Investments; Lead; Leadership; Malignant neoplasm of gastrointestinal tract; Manuscripts; Medical center; Methods; Outcome; Positioning Attribute; Reporting; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Resources; Secure; Statistical Data Interpretation; Translational Research; Universities; University Hospitals; Work; Writing; analytical method; career; data management; design; experimental study; medical schools; novel; programs; recruit; skills; success

PROJECT SUMMARY/ABSTRACT The Case GI SPORE Biostatistics and Informatics Core will interact with all SPORE investigators to develop and apply appropriate analysis methods, study designs and secure databases to most efficiently achieve project goals. We will work closely with investigators to ensure that research questions lead to experiments with quantifiable goals and testable hypotheses. In addition the Case GI SPORE Biostatistics and Informatics Core will provide infrastructure and oversight for secure management of all study data, working closely with the Biospecimen Core to facilitate accuracy and completeness of datasets for all projects and investigators. Our specific aims are: (1) To provide support to Case GI SPORE investigators in the design, conduct, analysis and reporting of results from Case GI SPORE studies and (2) To provide secure and accessible database systems to facilitate reliable and reproducible impactful results for all Case GI SPORE investigators. The Biostatistics and Informatics Core leverages faculty and resources in the Case Comprehensive Cancer Center, Case Western Reserve University (CWRU) School of Medicine and the Institute for Computational Biology (ICB) at CWRU. Drs. Jill Barnholtz-Sloan and Jonathan Haines will co-direct the Core. The Biostatistics and Informatics Core will serve as a centralized resource for all investigators involved in the Case GI SPORE, including the leaders of the 4 translational research projects, Developmental Research Program (DRP) investigators, Career Enhancement Program (CEP) investigators and leaders of the Biospecimen Core. The Core will assist investigators with all facets of statistical design, analysis and interpretation. Established as well as novel tailored analytic methods are available to promote scientific discovery for GI cancers within the Core. Core personnel will interact with SPORE investigators in all stages of research, from the formulation of the research questions, through experimental design, data management, data analysis (including outcomes analysis), interpretation, writing scientific manuscripts and grants, to dissemination of results. The Core will also facilitate access to secure and accessible database systems in order to assist with statistical analysis, discovery and collaboration. The Core will assist all investigators with development, management and reliability of their project data and will also integrate information across databases, such as incorporating clinical and experimental data with biospecimen data as provided by the Biospecimen Core. The Biostatistics and Informatics Core will provide a natural foundation for cross-pollination among the projects and Cores, the Core personnel collaborating with all project investigators and Core directors.

项目总结/摘要 案例GI SPORE生物统计学和信息学核心将与所有SPORE研究者互动， 应用适当的分析方法，研究设计和安全数据库，以最有效地实现项目 目标.我们将与研究人员密切合作，以确保研究问题导致实验， 可量化的目标和可检验的假设。此外，案例GI孢子生物统计学和信息学核心 将为所有研究数据的安全管理提供基础设施和监督，与 生物样本核心，以促进所有项目和研究者的数据集的准确性和完整性。我们 具体目标是：（1）在设计、实施、分析和 报告来自Case GI SPORE研究的结果，以及（2）提供安全和可访问的数据库系统 为所有Case GI SPORE研究者提供可靠和可重复的有影响力的结果。生物统计 和信息学核心利用教师和资源的情况下综合癌症中心，案例 西储大学（CWRU）医学院和计算生物学研究所（ICB）在 CWRU。Jill Barnholtz-Sloan博士和Jonathan Haines博士将共同指导核心。生物统计学和 Informatics Core将作为参与案例GI SPORE的所有研究者的集中资源， 包括4个转化研究项目的负责人，发展研究项目（DRP） 研究者、职业提升计划（CEP）研究者和生物样本核心的领导者。的 核心将协助研究者进行统计设计、分析和解释的各个方面。确立为 以及新的定制分析方法可用于促进胃肠道癌症的科学发现， 核心核心人员将在研究的所有阶段与SPORE研究人员互动，从制定 研究问题，通过实验设计，数据管理，数据分析（包括结果 分析），口译，撰写科学手稿和赠款，以传播结果。芯会 还为访问安全和可访问的数据库系统提供便利， 分析、发现和协作。核心将协助所有研究者进行开发、管理和 他们的项目数据的可靠性，也将整合跨数据库的信息，如纳入临床 以及实验数据和生物样本核心提供的生物样本数据。生物统计学和 信息学核心将为项目和核心之间的交叉授粉提供自然基础， 与所有项目调查员和核心主管合作的核心人员。