Core 2: Biostatistics

项目摘要 生物统计核心（核心C）将合作并提供全面的统计服务和基础设施 支持临床和临床前研究的所有研究项目在拟议的计划项目补助金。在 此外，它还将为数据管理和集成、信息学和计算提供支持，并协助 确定和解决项目活动过程中出现的复杂数据任务。核心 委员会成员将与项目调查人员合作，开展广泛的活动，包括制定 研究设计、数据采集和数据库管理、统计质量控制、患者研究 监测、数据分析和解释、摘要和手稿编写以及数据传播。 此外，当特定项目需要时，核心人员开发并实施创新的定制 与P01的研究者合作使用生物统计学方法和工具。核心C资源是 位于约翰霍普金斯大学肿瘤学系生物统计学和生物信息学部 医学院。该司由一个积极和坚定的生物统计学和生物信息学小组组成。 教师，以及非教师生物统计学家，生物信息学家和IT专家，可以访问国家的 艺术方法和广泛的专业知识。核心成员对此P01有坚定的承诺， 源于他们在αRPT研究中的长期合作。所有拟议项目均利用 每个目标的核心资源。 核心C的主要目标是指导和协助项目调查人员设计、实施 以及本P01中拟定的实验室、转化和临床研究的分析。该计划已 专门的生物统计学家彻底精通与项目相关的主题，所有 项目可以获得核心人员提供的广泛专业知识。此外，核心成员 定期互动，并与管理核心A和动物模型，病理学密切合作 组织核心（核心B）和患者数据核心（核心D），有助于相互作用和协同作用 在这些项目中。

Project Summary The Biostatistics Core (Core C) will collaborate and provide comprehensive statistics service and infrastructure support for clinical and pre-clinical studies to all Research Projects in the proposed Program Project Grant. In addition, it will provide support for data management and integration, informatics, and computing, and assist with the identification and solution of complex data tasks arising in the course of project activities. Core members will work with project investigators across a wide spectrum of activities, encompassing formulation of the study design, data acquisition and database management, statistical quality control, patient study monitoring, data analysis and interpretation, abstract and manuscript preparation, and data dissemination. Furthermore, when required by specific project, Core personnel develop and implement innovative customized biostatistics methodologies and tools in collaboration with investigators in the P01. The Core C Resource is housed in the Division of Biostatistics and Bioinformatics, Department of Oncology at Johns Hopkins University School of Medicine. The Division comprises an active and committed group of biostatistics and bioinformatics faculty, as well as non-faculty biostatisticians, bioinformaticians and IT specialists, with access to state-of-the art methodologies and a broad range of expertise. Core members have a strong commitment to this P01, stemming from their long-standing collaborations in the research of αRPT. All proposed Projects make use of this Core Resource in every Aim. The primary objective of the Core C is to guide and assist the project investigators in the design, conduct, and analysis of the laboratory, translational, and clinical studies proposed in this P01. The program has dedicated biostatisticians thoroughly versed in the subject matter associated with the projects, and all projects have access to the breadth of expertise provided by Core personnel. Additionally, Core members interact on a regular basis, and work closely with the Administrative Core A and Animal Models, Pathology and Tissue Core (Core B) and Patient Data Core (Core D), which contributes to interactions and synergy among the projects.