Smartphone-Based Solutions for Prospective Memory in Mild Cognitive Impairment and Dementia
基于智能手机的轻度认知障碍和痴呆症未来记忆解决方案
基本信息
- 批准号:10712097
- 负责人:
- 金额:$ 76.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2028-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdherenceAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAnteriorAppointmentBehavior TherapyCalendarCaringCatchment AreaCellular PhoneClinicClinicalCognitiveCommunitiesCompensationDataDementiaDisadvantagedDisparity populationElderlyEnrollmentEnsureEquityEthnic PopulationEventFamilyFoundationsFriendsFutureGoalsHealth PersonnelHippocampusImpaired cognitionImpairmentIndividualInequityInterventionIntervention StudiesInterviewLeadMedicineMemoryMemory impairmentOutcomePaperParticipantPatient SelectionPatientsPerformancePersonsPharmaceutical PreparationsPilot ProjectsPopulationPositioning AttributePrefrontal CortexProceduresQuality of lifeRandomizedRandomized, Controlled TrialsReminder SystemsReportingResearchRuralSample SizeSamplingSelf EfficacySiteStressSupport SystemSystemTechnologyTestingTimeTrainingUnderrepresented PopulationsWorkacceptability and feasibilityactive controlaging and technologycare recipientscaregivingcognitive changecognitive trainingdaily functioningdigitaldisadvantaged backgroundefficacy testingfamily burdenfollow-upimprovedinformantloved oneslow socioeconomic statusmedication compliancemembermild cognitive impairmentpatient orientedpilot trialpreservationprospective memoryracial populationrecruitsocialsocioeconomicssuccess
项目摘要
Abstract:
Alzheimer’s disease and related dementias lead to marked declines in daily functioning, independence, and
quality of life. One of the earliest cognitive changes in these conditions is impairment in prospective memory,
or the ability to remember future intentions such as taking medications at a given time. Prior intervention
studies that targeted prospective memory used mnemonic strategies or cognitive training, but these
approaches resulted in modest gains in clinical populations. By contrast, our Stage I pilot trial indicated that
smartphone-based memory aids (reminder apps) can be used by persons with mild cognitive impairment and
mild dementia to improve both subjective and objective prospective memory performance. Having established
feasibility and acceptability in the Stage I pilot study, we will now test for efficacy, durability, and generalizability
of benefits across diverse samples in a Stage II randomized controlled trial. We will recruit 200 participants
with mild cognitive impairment or mild dementia, half of whom will be from digitally-disadvantaged backgrounds
(low socioeconomic status, rural, or historically underrepresented groups). These populations are well-
captured by our clinical catchment areas. Participants will complete baseline assessments and then be
randomly assigned to a smartphone reminder app intervention or an active control condition that uses a paper-
based memory support system. Across a 4-week intervention period, participants will complete both patient-
selected and experimenter-assigned prospective memory assessments and receive booster training sessions
to promote self-efficacy with the intervention/control system. We will assess durability of effects at 3-month and
6-month follow-up sessions. It is unknown whether smartphone-based or paper-based approaches will be
better at supporting prospective memory across 6 months in older adults with cognitive impairment and digital
disadvantages. However, based on pilot data, we anticipate that the reminder app will be especially beneficial
to prospective memory because it provides automated reminders, allows care partners to “push” reminders
and events, and it includes daily alerts to use the app. As a secondary aim, we will simultaneously enroll family
or friend study partners to collect informant ratings, track how much study partners assist the participants, and
determine whether improving prospective memory in patients improves quality of life in study partners (e.g., by
reducing the double to-do list burden of remembering for themselves and for care recipients). As a third aim,
we will integrate quantitative and qualitative data to identify barriers and facilitators to smartphone interventions
in digitally-disadvantaged individuals who have historically been underrepresented in technology and dementia
research. This research will advance understanding of technology usage in older adults, inform whether
smartphone-based reminder apps are effective and durable relative to established paper-based approaches for
prospective memory, and provide the foundation for personalized cognitive medicine interventions.
摘要:
阿尔茨海默氏病和相关痴呆症导致日常功能,独立性,
生活质量在这些情况下,最早的认知变化之一是前瞻性记忆受损,
或者记住未来意图的能力,比如在给定的时间服用药物。事先干预
针对前瞻性记忆的研究使用了记忆策略或认知训练,但这些研究表明,
这些方法在临床人群中取得了适度的效果。相比之下,我们的第一阶段试点试验表明,
基于智能手机的记忆辅助工具(提醒应用程序)可供轻度认知障碍的人使用,
轻度痴呆,以改善主观和客观前瞻性记忆的表现。建立了
在第一阶段的试验研究中,我们已经确定了可行性和可接受性,现在我们将测试其有效性、持久性和普遍性
II期随机对照试验中不同样本的获益。我们将招募200名参与者
患有轻度认知障碍或轻度痴呆症,其中一半将来自数字弱势背景
(low社会经济地位、农村或历史上代表性不足的群体)。这些人很好-
由我们的临床服务区捕获。参与者将完成基线评估,
随机分配到智能手机提醒应用程序干预或使用纸张的主动控制条件,
内存支持系统。在为期4周的干预期间,参与者将完成两项患者-
选择和实验者指定的前瞻性记忆评估,并接受助推器培训课程
通过干预/控制系统提高自我效能。我们将在3个月时评估效果的持久性,
6-月的后续会议。目前尚不清楚是否基于智能手机或基于纸张的方法将
更好地支持患有认知障碍和数字化的老年人6个月的前瞻性记忆
缺点然而,根据试点数据,我们预计提醒应用程序将特别有益
由于它提供自动提醒,允许护理伙伴“推送”提醒,因此可以增强前瞻性记忆
和事件,它包括每日警报使用的应用程序。作为第二个目标,我们将同时注册家庭
或朋友研究伙伴收集线人评级,跟踪研究伙伴帮助参与者的程度,
确定改善患者的前瞻性记忆是否改善了研究伙伴的生活质量(例如,通过
减少为自己和护理接受者记住双重待办事项清单的负担)。作为第三个目标,
我们将整合定量和定性数据,以确定智能手机干预的障碍和促进因素
在数字弱势群体中,他们在技术和痴呆症方面的代表性不足,
research.这项研究将促进对老年人技术使用的理解,
基于智能手机的提醒应用程序相对于已建立的基于纸张的方法有效且持久,
前瞻性记忆,并为个性化认知医学干预提供基础。
项目成果
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