DRP: Developmental Research Program

DRP：发展研究计划

• 批准号: 10713058
• 负责人: Alexander Olawaiye
• 金额: $ 11.09万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10713058
• 关键词: Advocate; Annual Reports; Application procedure; Area; Award; Bioinformatics; Biometry; Cancer Center; Cancer Research Project; Cessation of life; Clinical; Clinical Trials; Collaborations; Communities; Core Facility; Data; Development; Disease; Doctor of Philosophy; Early Diagnosis; Electronic Mail; Eligibility Determination; Ensure; Extramural Activities; Feedback; Financial Support; Fostering; Funding; Goals; Hospitals; Incubators; Individual; Infrastructure; Institution; Investments; Joints; Laboratories; Lead; Malignant Neoplasms; Malignant neoplasm of ovary; Mentors; Minority; Minority-Serving Institution; Monitor; Morbidity - disease rate; Outcome; Patients; Peer Review; Pilot Projects; Population; Population Sciences; Prevention; Process; Prognostic Marker; Program Research Project Grants; Progress Reports; Research; Research Personnel; Research Project Grants; Resources; Science; Scientist; Sister; Specimen; Testing; Tissues; Underrepresented Minority; United States National Institutes of Health; Universities; Vertebral column; Woman; Work; anticancer research; cohort; disability; equity, diversity, and inclusion; experience; flexibility; high reward; high risk; innovation; inter-institutional; meetings; member; minority investigator; mortality; mouse model; next generation; novel; outreach; peer; predictive marker; programs; recruit; repository; standard of care; success; therapy resistant; translational impact; tumorigenesis; web site

PROJECT SUMMARY – DEVELOPMENTAL RESEARCH PROGRAM (DRP) The Developmental Research Program (DRP) of the UPMC Hillman Cancer Center (HCC) Ovarian Cancer SPORE seeks to fund and facilitate translationally-driven, innovative pilot projects in ovarian cancer. The overarching goal is to decrease ovarian cancer morbidity and mortality through stimulating new research in the areas of prevention and early detection; mechanisms of tumorigenesis and therapeutic resistance; predictive and prognostic biomarkers; and novel targets and approaches to therapy. An additional goal of the DRP is to establish support for underrepresented minorities in ovarian cancer research. To accomplish these goals, DRP will build on the successful program and infrastructure developed via a previous joint P50 award that resulted in an approximate 35-fold return on investment. The DRP will widely solicit proposals annually using local and national networks. To increase recruitment of underrepresented minorities to our DRP program, DRP will leverage University of Pittsburgh and HCC programs with Minority Serving Institutions to increase the participation of under-represented scientists. Additionally, members of the Internal and External Advisory Boards will be encouraged to identify investigators who could contribute to the diversity of the DRP. The most meritorious proposals will be selected based on an NIH-style two-tiered review to ensure rigor and absence of bias. The DRP Co-Directors, SPORE Executive Committee, Patient Advocates, and SPORE investigators will participate in the first-tier scientific review, together with ad hoc revewers when necessary. The final selection of awardees will be made following a second-tier programmatic review involving the SPORE Internal Advisory Board. Each award will provide $50,000 in funds, with half of the monies coming from the DRP and the other half from HCC, demonstrating substantial institutional commitment. DRP will fund three pilots per year, reserving one for an underrepresented minority investigator. DRP awardees new to ovarian cancer will be assigned an experienced mentor to provide guidance and integration into the SPORE. Awardees will be provided full access to the HCC Ovarian Cancer SPORE Core resources, including tissue specimens and bioinformatic/biostatistical support, not only to ensure project success but also to support subsequent funding applications outside the SPORE mechanism. All DRP awardees will meet bi-annually with the DRP Co- Directors, prepare progress reports annually, and make research presentations at SPORE meetings. Those that demonstrate significant research progress will be eligible for competitive renewal for a second year. Exceptional pilots with potential for significant translational impact can be elevated to full SPORE projects. The DRP provides a vital mechanism for achieving the SPORE’s goal of developing a diverse pool of ovarian cancer researchers committed to overcoming this deadly disease.

项目摘要 - 发展研究计划（DRP） UPMC Hillman癌症中心（HCC）卵巢癌的发展研究计划（DRP） 孢子试图资助和促进卵巢癌的翻译驱动，创新的试点项目。这 总体目标是通过刺激新研究来降低卵巢癌的发病率和死亡率 预防和早期检测领域；肿瘤发生和治疗性抗性的机制；预测性 和预后的生物标志物；以及新颖的靶标和治疗方法。 DRP的另一个目标是 在卵巢癌研究中为代表性不足的少数民族建立支持。为了实现这些目标，DRP 将建立在成功的计划和通过以前的联合P50奖中开发的基础设施的基础上，该奖项导致 在大约35倍的投资回报中。 DRP每年将使用本地和 国家网络。为了增加我们DRP计划中代表性不足的少数群体的招聘，DRP Will 利用匹兹堡大学和HCC计划拥有少数派服务机构，以增加 代表性不足的科学家的参与。此外，内部和外部咨询的成员 鼓励董事会确定可以为DRP多样性做出贡献的调查人员。最多 将根据NIH风格的两层审查选择功绩的提案，以确保严格和缺乏 偏见。 DRP联合导演，孢子执行委员会，患者拥护者和孢子调查人员将 参与一级科学评论，并在必要时揭示。最终选择 在涉及孢子内部咨询的第二层程序审查之后，获奖者将被制作 木板。每个奖项将提供50,000美元的资金，其中一半的资金来自DRP，另一款来自DRP 一半来自HCC，表明了实质性的机构承诺。 DRP每年将资助三名飞行员 为一个代表性不足的少数群体调查员保留一个。 DRP奖项是卵巢癌的新奖项 分配了经验心态，以提供指导和整合到孢子中。获奖者将是 提供了完全访问HCC卵巢癌孢子核心资源，包括组织标本和 生物信息学/生物统计学支持，不仅是为了确保项目成功，而且还支持后续资金 孢子机制以外的应用。所有DRP获奖者都将同时与DRP共同见面 董事，每年准备进度报告，并在孢子会议上进行研究演讲。那些 这表明研究进展的重大进展将有资格获得第二年的竞争性更新。 具有重大翻译影响潜力的杰出飞行员可以提升为完整的孢子项目。这 DRP提供了一个至关重要的机制，可以实现孢子的目标，即开发卵巢的潜水者 癌症研究人员致力于克服这种致命的疾病。