IUB C3A Pilot Project Core

IUB C3A 试点项目核心

• 批准号: 10713093
• 负责人: Norbert Hajos
• 金额: $ 15.79万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10713093
• 关键词: Address; Adolescent; African-American Graduate Student; Anatomy; Applications Grants; Area; Cannabinoids; Cannabis; Career Choice; Clinical; Data; Drug Addiction; Drug abuse; Drug usage; Education; Educational Status; Ensure; Equity; Experimental Designs; Feedback; Funding; Gills; Goals; Grant; Human; Image; Indiana; Individual; Inhalation; Kentucky; Knowledge; Lipids; Location; Mentors; Methodology; Modeling; Molecular; National Institute of Drug Abuse; Nature; Neurosciences; Opioid; Outcome; Pilot Projects; Plasma; Population; Postdoctoral Fellow; Process; Publications; Rattus; Research; Research Personnel; Resources; Scientist; Societies; Substance abuse problem; Summary Reports; Support Groups; System; THC exposure; Talents; Techniques; Traumatic Brain Injury; Universities; Work; Writing; addiction; career; cognitive change; design; experimental study; graduate student; high risk; innovation; insight; interest; lipidome; lipidomics; meetings; member; mild traumatic brain injury; multiple drug use; novel; opioid user; phytocannabinoid; process improvement; professor; programs; recruit; skills; success

Pilot Project Core Abstract The IUB Center for Cannabis, Cannabinoids and Addiction (C3A) Pilot Project Core will establish a pilot project program designed to support 2 to 4 new projects/year. The Pilot Project Core PI is Professor Norbert Hájos, who holds a Gill Chair of Neuroscience. Its goal is to support and encourage innovative and exploratory projects from trainees and establish investigators exploring new lines of research related to substance abuse. Pilot projects will be solicited annually from C3A Affiliates and their trainees. We anticipate that some of these pilot project proposals will come from trainees supported by our NIDA-T32, DA024628. Each proposal will be reviewed by 2 members of the External Advisory Board and 2 members of the Internal Advisory Board. Proposals will be ranked by the following priorities: 1. Support of young investigators/investigators new to the addiction field. 2. Support of groups historically underrepresented in drug abuse research. 3. A project that will maximally benefit from access to either the BLM or MSPM cores. 4. Obtain preliminary data for NIDA grant application. 5. Includes a component of high risk/high payout. Low priority will be given to proposals that merely supplement ongoing funded research. All applicants will receive feedback on their proposals and will be offered the opportunity to be mentored by a C3A PI or Affiliate in subsequent applications to the C3A or external agencies. Successful applicants will be assigned a Core staff member to optimize experimental design with the technical capabilities of the relevant core(s) utilized and matched with a IUB C3A Center Affiliate to provide guidance in the substance abuse field. Awardees will present their work at least three times to the monthly C3A research meetings and once to the external advisory board. A summary report will also be prepared when the project is completed. Based on these criteria, we have chosen two projects for the initial submission of this P30. Pilot Project 1 has been proposed by Gabriel Nah, a graduate student working with Dr. Jonathan Crystal, a Provost Professor at IU Bloomington. Mr. Nah’s project uses a rat model to examine the impact of adolescent THC exposure on the lipidomic, anatomical, molecular, and cognitive changes following mild traumatic brain injury and will use both the lipidomics and imaging cores. Pilot Project 2 has been proposed by Center Affiliate, Dr. Shanna Babalonis, as assistant professor at the University of Kentucky studying multi-drug use in human populations. Dr. Babalonis’ project will use the lipidomics core to examine the plasma lipidome and phytocannabinoid levels in opioid users in a controlled setting with and without inhaled cannabis exposure. These two pilot projects meet the goals of the Pilot Project Core in the following ways: Project 1 supports an African American graduate student working on a significant question addressing the impact of prior drug use on the sequelae of traumatic brain injury. Project 2 supports an early-stage investigator examining the interactions between cannabinoids, lipids, and opioids in a clinical population.

试点项目核心摘要 IUB大麻、大麻素和成瘾中心（C3 A）试点项目核心将建立一个试点项目， 计划每年支持2至4个新项目。试点项目核心PI是Norbert Hájos教授， 神经科学的吉尔主席其目标是支持和鼓励创新和探索 培训学员的项目，并设立调查员，探索与药物滥用有关的新的研究方向。 每年将向C3 A附属公司及其受训人员征集试点项目。我们预计其中一些 试点项目提案将来自我们的NIDA-T32，DA 024628支持的学员。每项提案将 由2名外部咨询委员会成员和2名内部咨询委员会成员审查。 建议将按以下优先顺序排列：1。对年轻调查员/新调查员的支助 成瘾领域2.支持历来在药物滥用研究中代表性不足的群体。3.的项目 将最大限度地受益于对BLM或MSPM内核的访问。4.获取NIDA赠款的初步数据 应用程序. 5.包括高风险/高支出的组成部分。以下建议将得到较低的优先考虑： 只是对正在进行的资助研究的补充。所有申请人都将收到对他们提案的反馈， 在随后的C3 A申请中，有机会得到C3 A PI或附属机构的指导，或 外部机构。成功的申请者将被分配一名核心工作人员，以优化实验 利用相关核心的技术能力进行设计，并与IUB C3 A中心相匹配 附属机构提供药物滥用领域的指导。获奖者将展示他们的工作至少三次 每月的C3 A研究会议和一次外部咨询委员会。还将提交一份总结报告， 当项目完成时准备。 根据这些标准，我们选择了两个项目作为P30的初始提交。试点项目1 由Gabriel Nah提出，他是一名研究生，与Jonathan Crystal博士一起工作，Jonathan Crystal博士是哈佛大学的教务长教授。 IU布卢明顿。Nah先生的项目使用老鼠模型来研究青少年接触THC对他们的影响。 轻度创伤性脑损伤后的脂质组学、解剖学、分子学和认知变化， 脂质组学和成像核心。试点项目2由中心附属机构Shanna Babalonis博士提出， 他是肯塔基州大学的助理教授，研究人群中多种药物的使用。博士 Babalonis的项目将使用脂质组学核心来检查血浆脂质组和植物大麻素水平， 阿片类药物使用者在受控环境中有和没有吸入大麻暴露。这两个试点项目 试点项目核心的目标在以下方面：项目1支持非洲裔美国人毕业生 学生工作的一个重要问题，解决以前的药物使用对创伤后遗症的影响 脑损伤项目2支持早期研究人员检查大麻素之间的相互作用， 脂质和阿片类药物。