Administrative Core

行政核心将协调项目与大型动物和 显微镜核心。组成P01的三个项目的成功执行情况如下 这是检验中心假说所必需的。新皮质网络结构的量化(项目 2)和氯-i和氯-o(方案3)必须在脑损伤后作为时间的函数来测量 癫痫的发生(项目1)。这些项目都使用相同的实验队列，以便 降低成本和动物使用量。因此，项目之间的密切协调至关重要。 行政核心对项目的协调极大地促进了同步数据 收集和分析相同的动物。实验和动物注册是错开的 在赠款期限内尽量减少隔室和手术中的空间需求 并最大限度地高效、持续地利用空间和人员。 行政核心将协调项目会议。调查人员目前每月会面一次 审查本项目第一阶段(工具开发)的结果。我们计划继续这样做 每月召开会议，审查进展情况，解决问题，协调研究计划。 提案的这一节介绍了行政核心的协调情况。 管理核心将促进P01与外部科学家和 组织。除了每月举行项目和核心会议外，行政核心 还将组织与调查人员、顾问和指导人员举行季度会议 委员会审议阶段。在这些会议上，将审查研究的总体方向， 将讨论手稿，并将在国内和国际会议上发表演讲 地址。 行政核心将促进政策管理和执行内部和 与项目相关的制度政策。 管理核心将管理项目之间的数据传输、数据归档和访问 外部调查人员对数据的了解。 管理核心将协调与监管机构、供应商和 专业组织。

The Administrative Core will coordinate efforts between the Projects and Large Animal and Microscopy Cores. Successful execution of the three projects that comprise this P01 are necessary to test the central hypothesis. Quantification of neocortical network structure (Project 2) and Cl-i and Cl-o (Project 3) must be measured as a function of time after brain injury and epileptogenesis (Project 1). These projects all utilize the same experimental cohort in order to reduce costs and animal usage. Thus close coordination among the projects is essential. Coordination of projects by the Administrative Core greatly facilitates simultaneous data collection and analysis on the same animals. Experiments and animal enrollment are staggered across the duration of the grant to minimize space requirements in the vivarium and operating room and maximize the efficient, continuous utilization of space and personnel. The Administrative Core will coordinate project meetings. Investigators currently meet monthly to review results of Phase I of this project (tool development). We plan to continue these monthly meetings to review progress, address problems, and coordinate research schedules. Coordination by the Administrative Core is described in this section of the proposal. The Administrative core will facilitate the interface of the P01 with external scientists and organizations. In addition to monthly meetings of projects and cores, the Administrative Core will also organize quarterly meetings with the investigators, consultants and the steering committee. At these meetings, the overall direction of the research will be reviewed, manuscripts will be discussed, and presentations at national and international meetings will be addressed. The administrative core will facilitate policy management and the execution of both internal and institutional policies relevant to the project. The administrative core will manage data transfer between projects, data archiving, and access to the data by external investigators. The Administrative Core will coordinate interactions with regulatory agencies, vendors, and professional organizations.