Administrative Core

行政核心

• 批准号: 10713241
• 负责人: Kevin J. Staley
• 金额: $ 4.93万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10713241
• 关键词: Address; Administrative Coordination; Administrator; Animals; Authorship; Biomedical Engineering; Boston; Brain Injuries; Budgets; Communication; Communities; Consultations; Data; Data Analyses; Data Collection; Data Storage and Retrieval; Discrimination; Documentation; Education; Enrollment; Epileptogenesis; Feedback; Funding; Goals; Grant; Human Resources; Institutional Policy; Intellectual Property; International; Manuscripts; Mathematics; Measures; Microscopy; Monitor; Neocortex; Neurology; Neurosciences; Operating Rooms; Persons; Phase; Policies; Post-Traumatic Epilepsy; Preparation; Professional Organizations; Progress Reports; Publications; Research; Research Personnel; Research Project Grants; Review Committee; Schedule; Scientific Misconduct; Scientist; Series; Structure; Testing; Time; United States National Institutes of Health; Universities; Vendor; Visit; archive data; career; cohort; cost; data archive; data exchange; data management; experimental study; lectures; medical schools; meetings; neocortical; neuropathology; programs; statistics; tool development; virtual

The Administrative Core will coordinate efforts between the Projects and Large Animal and Microscopy Cores. Successful execution of the three projects that comprise this P01 are necessary to test the central hypothesis. Quantification of neocortical network structure (Project 2) and Cl-i and Cl-o (Project 3) must be measured as a function of time after brain injury and epileptogenesis (Project 1). These projects all utilize the same experimental cohort in order to reduce costs and animal usage. Thus close coordination among the projects is essential. Coordination of projects by the Administrative Core greatly facilitates simultaneous data collection and analysis on the same animals. Experiments and animal enrollment are staggered across the duration of the grant to minimize space requirements in the vivarium and operating room and maximize the efficient, continuous utilization of space and personnel. The Administrative Core will coordinate project meetings. Investigators currently meet monthly to review results of Phase I of this project (tool development). We plan to continue these monthly meetings to review progress, address problems, and coordinate research schedules. Coordination by the Administrative Core is described in this section of the proposal. The Administrative core will facilitate the interface of the P01 with external scientists and organizations. In addition to monthly meetings of projects and cores, the Administrative Core will also organize quarterly meetings with the investigators, consultants and the steering committee. At these meetings, the overall direction of the research will be reviewed, manuscripts will be discussed, and presentations at national and international meetings will be addressed. The administrative core will facilitate policy management and the execution of both internal and institutional policies relevant to the project. The administrative core will manage data transfer between projects, data archiving, and access to the data by external investigators. The Administrative Core will coordinate interactions with regulatory agencies, vendors, and professional organizations.

行政核心将协调项目和大型动物之间的努力， 显微镜核心。成功执行构成本P01的三个项目是 测试中心假设的必要条件。新皮层网络结构的量化（项目 2)Cl-1和Cl-0（项目3）必须作为脑损伤后时间的函数进行测量， 癫痫发生（项目1）。这些项目都使用相同的实验队列，以便 降低成本和动物使用。因此，项目之间的密切协调至关重要。 由行政核心协调项目，极大地促进了同步数据 对相同动物进行收集和分析。实验和动物登记是错开的 在整个拨款期间，以尽量减少对动物园和操作空间的需求。 最大限度地提高空间和人员的有效、持续利用率。 行政核心将协调项目会议。调查人员目前每月举行一次会议 审查本项目第一阶段（工具开发）的结果。我们计划继续这些 每月召开一次会议，审查进展情况，解决问题，并协调研究计划。 建议书的这一部分介绍了行政核心的协调工作。 行政核心将促进P01与外部科学家的接口， 组织的除了每月举行项目和核心会议外， 还将组织与调查人员、顾问和指导人员的季度会议， 以马克思在这些会议上，将审查研究的总体方向， 手稿将被讨论，并在国家和国际会议上的演讲将被 处理。 行政核心将促进政策管理和执行内部和 与项目相关的政策。 管理核心将管理项目之间的数据传输、数据归档和访问 外部调查人员的数据。 行政核心将协调与监管机构、供应商和 专业组织。