Transforming Resuscitation through Artificial INtelligence (TRAIN Study)
通过人工智能改变复苏(TRAIN 研究)
基本信息
- 批准号:10712407
- 负责人:
- 金额:$ 71.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-01 至 2028-05-31
- 项目状态:未结题
- 来源:
- 关键词:AccountingAcuteAdultAffectAlgorithmsAnti-Arrhythmia AgentsArtificial IntelligenceBlindedCarbon DioxideCaringCessation of lifeChestChildhoodClinicalDecision MakingDefibrillatorsDoseElectric CountershockElectrocardiogramExperimental ModelsFunctional disorderGoalsHeart ArrestHeterogeneityHospitalsHypoxiaImpedance CardiographyIndividualIntelligenceInterruptionInvestigationMeasuresMonitorMorphologic artifactsMorphologyMyocardial IschemiaOutcomePatientsPerformancePerfusionPhenotypePhysiologic pulsePhysiologicalPhysiologyPopulationProcessPrognosisProtocols documentationProviderPublic HealthResearchResuscitationSignal TransductionSystemTechniquesTechnologyTestingTimeTranslatingUnited StatesVasoconstrictor AgentsVentricular FibrillationVital Statusartificial intelligence methodblindclinical applicationclinical phenotypecomputerized data processingdata resourcedigitalelectric impedanceimprovedindividual patientindividualized medicineinnovationmortalitymultidisciplinarynovel strategiesoptimal treatmentsout-of-hospital cardiac arrestpersonalized approachprecision medicinepreventprognosticprospectiverandomized trialsignal processing
项目摘要
Project Summary
Mortality from out-of-hospital sudden cardiac arrest (OHCA) is a large public health burden, accounting for
approximately 10% of all deaths in the US. Because OHCA is a leading cause of mortality, advances in
resuscitation have the potential to improve public health. Currently resuscitation protocols use a one-size-fits-
all approach. However, we now understand that OHCA occurs via heterogeneous mechanisms and manifests
a time-dependent pathophysiology, which influences prognosis. The heterogeneity suggests discrete clinical
phenotypes and an opportunity for individualized therapy. Distinguishing information about patient physiology
can be harnessed from the defibrillator. Continuous bio-measures of ECG, end-tidal carbon dioxide (ETCO2),
and transthoracic impedance (TI) can determine physiologic status and potentially guide optimal treatment.
However, a real-time continuous approach to characterize a patient’s physiology and prognosis by
accurately determining the underlying rhythm and its vitality is not presently feasible without repeatedly
interrupting CPR. CPR interruption is required because chest compressions introduce ECG artifact that
prevents rhythm identification, prognostic assessment of rhythm morphology, and a patient’s underlying vital
status (vitality). However, CPR interruption is harmful since it disrupts perfusion in the otherwise pulseless
OHCA victim. Consequently, the current protocol is a compromise: CPR is interrupted every 2 minutes to help
inform care decisions though treatment proceeds empirically as CPR resumes and providers are typically
“blinded” to the actual underlying rhythm and vital status.
Emerging evidence from the proposal team highlight the ability to use signal processing techniques to
investigate the ECG, ETCO2, and TI defibrillator signals during CPR to improve OHCA resuscitation. These
investigations use artificial intelligence (AI) methods to determine a patient’s instantaneous physiological status
and predict downstream resuscitation outcomes. We propose an investigative plan that will:
1. Derive and validate an integrated ventricular fibrillation (VF) OHCA algorithm that incorporates and builds
upon previously-validated modular algorithms, using artificial intelligence (AI) methods that process and
integrate ECG, TI, and ETCO2 bio-signals during active CPR.
2. Prospectively evaluate the integrated algorithms and their validated building block components in distinct
adult and pediatric OHCA populations.
3. Conduct a simulated randomized trial among EMS to compare the described precision strategy to the
current-day, fixed protocol to understand how dynamic prompts of a precision strategy affect CPR metrics.
The project leverages an unparalleled data resource and a tested, multidisciplinary team with a track-record
of impactful resuscitation investigations involving novel approaches to AI and resuscitation. This consequent
precision strategy ultimately could transform resuscitation and improve public health.
项目摘要
院外心脏骤停(OHCA)的死亡率是一个巨大的公共卫生负担,
大约占美国死亡人数的10%。由于OHCA是死亡的主要原因,
复苏有可能改善公众健康。目前的复苏方案都是一刀切的
所有方法。但是,我们现在知道OHCA是通过异构机制和清单发生的
时间依赖性病理生理学,影响预后。异质性表明离散的临床
表型和个性化治疗的机会。区分患者生理信息
可以从除颤器中利用。ECG、呼气末二氧化碳(ETCO 2)的连续生物测量,
和经胸阻抗(TI)可以确定生理状态并潜在地指导最佳治疗。
然而,实时连续的方法来表征患者的生理和预后,
准确地确定潜在的节奏及其活力目前是不可行的
打断了心肺复苏需要CPR中断,因为胸部按压会引入ECG伪影,
阻止心律识别、心律形态的预后评估以及患者的潜在生命体征,
状态(活力)。然而,CPR中断是有害的,因为它破坏了在其他无脉搏的情况下的灌注。
OHCA受害者。因此,目前的协议是一个妥协:心肺复苏术是中断每2分钟,以帮助
尽管当CPR恢复时治疗根据经验进行,但是提供者通常
对实际的潜在节律和生命状态“盲”。
提案团队提出的新证据强调了使用信号处理技术的能力,
研究CPR期间的ECG、ETCO2和TI除颤器信号,以改善OHCA复苏。这些
调查使用人工智能(AI)方法来确定患者的瞬时生理状态
并预测下游复苏结果。我们提出一项调查计划,将:
1.推导并验证集成的室颤(VF)OHCA算法,
基于先前验证的模块化算法,使用人工智能(AI)方法,
在主动CPR期间集成ECG、TI和ETCO2生物信号。
2. Proximity评估集成算法及其经过验证的构建块组件,
成人和儿童OHCA人群。
3.在EMS中进行模拟随机试验,以比较所述精密度策略与
当前的固定协议,以了解精确策略的动态提示如何影响CPR指标。
该项目利用了无与伦比的数据资源和经过测试的多学科团队,
涉及人工智能和复苏新方法的有影响力的复苏研究。这个后果
精确的策略最终可以改变复苏并改善公共卫生。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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THOMAS D REA其他文献
THOMAS D REA的其他文献
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{{ truncateString('THOMAS D REA', 18)}}的其他基金
Human genetic variation and ventricular fibrillation resuscitation outcomes
人类遗传变异和心室颤动复苏结果
- 批准号:
7868043 - 财政年份:2008
- 资助金额:
$ 71.34万 - 项目类别:
Human genetic variation and ventricular fibrillation resuscitation outcomes
人类遗传变异和心室颤动复苏结果
- 批准号:
8079061 - 财政年份:2008
- 资助金额:
$ 71.34万 - 项目类别:
Human genetic variation and ventricular fibrillation resuscitation outcomes
人类遗传变异和心室颤动复苏结果
- 批准号:
7640734 - 财政年份:2008
- 资助金额:
$ 71.34万 - 项目类别:
Human genetic variation and ventricular fibrillation resuscitation outcomes
人类遗传变异和心室颤动复苏结果
- 批准号:
7380891 - 财政年份:2008
- 资助金额:
$ 71.34万 - 项目类别:
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