Dynamic Imaging of Lung Ventilation and Perfusion Using CT and MRI

肺结构和功能的动态氧增强MRI，PI：Sean B。费恩 摘要 该项目将开发和优化肺动态通气的氧增强（OE）成像 同时在单次自由呼吸7分钟内高分辨率采集肺实质解剖结构 使用3D超短时间回波（UTE）MRI进行采集。3D UTE MRI的进步现在支持区域成像 肺部解剖结构的CT样对比度，全胸部覆盖，各向同性1 mm空间分辨率。我们会委聘 基于流形的深度学习和UTE中心向外k空间的高级运动补偿重建 轨迹，以将呼吸运动与自由运动期间由于氧气洗入和洗出引起的T1变化隔离开来， 呼吸了由此产生的运动补偿重建提供定量通气和高通气率。 分辨率结构在一个单一的7分钟系列。将用这种方法研究多种慢性肺部疾病 与定量胸部CT和超极化相比，确定该方法的实用性和可重复性 129毫米核磁共振。我们的初步数据表明，在肺功能不全的患者中，仅使用MRI检查肺结构和通气功能是有用的。 其方式类似于使用Technegas的核SPECT和X射线CT，但没有电离辐射。 我们假设通气动力学的3D UTE MR成像将捕获共定位的结构-功能， 监测与肺部疾病的结构特征相关的通气异质性，包括纤维化，肉芽肿， 粘液堵塞、支气管扩张、毛玻璃和纤维化。将进行放射学专家阅片员研究 直接比较UTE MRI与定量胸部CT，以描述结构和功能（衍生） 从静态多容积图像）异常，以及OE MRI局部通气模式到超极化 129毫米核磁共振。本研究旨在建立一种评价慢性肺损伤结构-功能的MRI方法和方案 广泛接触的疾病，无电离辐射暴露（允许纵向评估， 粒度），并使用安全、廉价和广泛可用的顺磁气体。的具体目标 项目旨在：1）提高临床场强下3D UTE MRI的数据采集效率; 2）开发 自由呼吸期间氧气通气洗入和洗出的动态OE MRI，以及3）开发OE MRI可视化和分析工具，用于区域结构-功能关联。3D OE MRI 方法是廉价的，使用质子为基础的对比，可以表征结构和功能方面 以类似于SPECT/CT的方式诊断慢性肺部疾病，无需担心电离辐射暴露。

Dynamic Oxygen-Enhanced MRI of Lung Structure and Function, PI: Sean B. Fain. Abstract This project will develop and optimize oxygen-enhanced (OE) imaging of dynamic ventilation of the lungs simultaneously with high resolution acquisition of lung parenchymal anatomy in a single, free-breathing 7-minute acquisition using 3D ultra-short time to echo (UTE) MRI. Advances in 3D UTE MRI now support regional imaging of lung anatomy with CT-like contrast, full chest coverage, and isotropic 1 mm spatial resolution. We will employ advanced motion compensation reconstruction with manifold-based deep learning and UTE center-out k-space trajectories to isolate respiratory motion from T1 changes due to oxygen wash-in and wash-out during free- breathing. The resulting motion compensated reconstruction provides both quantitative ventilation and high- resolution structure in a single 7-minute series. Multiple chronic lung diseases will be studied with this approach to establish utility and repeatability of the method in comparison to quantitative chest CT and hyperpolarized 129Xe MRI. Our preliminary data demonstrates the utility of MRI-only exam of lung structure and ventilation in a manner similar to that provided by nuclear SPECT with technegas and X-ray CT but without ionizing radiation. We hypothesize that 3D UTE MR imaging of ventilation dynamics will capture co-localized structure-function for monitoring ventilation heterogeneity relative to structural features of lung disease, including fibrosis, granulomas, mucus plugging, bronchiectasis, ground glass, and fibrosis. Radiology expert reader studies will be performed with direct comparison of UTE MRI with quantitative chest CT for depiction of structural and functional (derived from static multi-volumetric images) abnormalities, and OE MRI regional patterns of ventilation to hyperpolarized 129Xe MRI. We seek to create an MRI method and protocol for structure-function assessment of chronic lung disease with broad access, no exposure to ionizing radiation (allowing for longitudinal assessment at increased granularity), and using a safe, inexpensive and widely available paramagnetic gas. The specific aims of the project are to: 1) Improve data acquisition efficiency for 3D UTE MRI at clinical field strengths; 2) Develop dynamic OE MRI of oxygen ventilation wash-in and wash-out during free breathing, and 3) Develop OE MRI visualization and analysis tools for regional structure-function associations. The 3D OE MRI approach is inexpensive, uses proton-based contrast and can characterize both structural and functional aspects of chronic lung disease in a manner similar to SPECT/CT without concern for ionizing radiation exposure.