R35 Admin Diversity Supplement: Regulation of alternative splicing during epithelial-mesenchymal transition

摘要 本附录的目标是支持多样性的研究、培训和职业发展 郑崇辉博士实验室的研究生。家长拨款的目标是调查 RNA结合蛋白对上皮-间充质转化过程中选择性剪接的调节 (EMT)，一种与许多类型的疾病相关的发育计划，包括组织 纤维化和癌症转移。我们精心制定了培训计划，职业发展计划， 和指导计划，将提高学生的智力和技术技能，并促进 他的职业发展。研究生将：(1)积极开展毕业论文项目 了解RNA结合蛋白如何调控剪接和翻译相互交织以控制 EMT；(2)接受广泛的实验和计算培训；(3)获得合作和 领导技能；(4)提交博士前奖学金；(5)产生研究成果和 参与撰写发表在同行评议期刊上的文章；(6)参加并在《科学》杂志上发表 开会。

ABSTRACT The goal of this supplement is to support research training and career development of a Diversity graduate student in Dr. Chonghui Cheng’s laboratory. The goal of the parent grant is to investigate the regulation of alternative splicing by RNA binding proteins in epithelial-mesenchymal transition (EMT), a developmental program that is associated with many types of diseases, including tissue fibrosis and cancer metastasis. We have carefully crafted training plan, career development plan, and mentoring plan that will enhance the student’s intellectual and technical skills and facilitate his career development. The graduate student will: (1) Actively conduct his thesis project towards understanding how RNA binding protein regulated splicing and translation intertwine to control EMT; (2) Receive extensive experimental and computational trainings; (3) Gain collaboration and leadership skills; (4) Submit predoctoral fellowships; (5) Generate research findings and participate in writing for publication in peer-reviewed journals; (6) Attend and present in Scientific meetings.