R35 Admin Diversity Supplement: Regulation of alternative splicing during epithelial-mesenchymal transition

R35 管理多样性补充：上皮-间质转化过程中选择性剪接的调节

• 批准号: 10720983
• 负责人: Chonghui Cheng
• 金额: $ 6.58万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10720983
• 关键词: Alternative Splicing; Collaborations; Creativeness; Development; Development Plans; Disease; Epithelium; Fellowship; Fibrosis; Funding; Goals; Journals; Laboratories; Leadership; Mentors; Mesenchymal; Neoplasm Metastasis; Parents; Peer Review; Publications; RNA Splicing; RNA-Binding Proteins; Regulation; Research; Research Support; Research Training; Scientist; Students; Technical Expertise; Tissues; Training; Training Support; Translations; Writing; career development; graduate student; meetings; parent grant; pre-doctoral; programs; skills

ABSTRACT The goal of this supplement is to support research training and career development of a Diversity graduate student in Dr. Chonghui Cheng’s laboratory. The goal of the parent grant is to investigate the regulation of alternative splicing by RNA binding proteins in epithelial-mesenchymal transition (EMT), a developmental program that is associated with many types of diseases, including tissue fibrosis and cancer metastasis. We have carefully crafted training plan, career development plan, and mentoring plan that will enhance the student’s intellectual and technical skills and facilitate his career development. The graduate student will: (1) Actively conduct his thesis project towards understanding how RNA binding protein regulated splicing and translation intertwine to control EMT; (2) Receive extensive experimental and computational trainings; (3) Gain collaboration and leadership skills; (4) Submit predoctoral fellowships; (5) Generate research findings and participate in writing for publication in peer-reviewed journals; (6) Attend and present in Scientific meetings.

摘要 该补充的目标是支持多样性的研究培训和职业发展 Chonghui Cheng博士实验室的研究生。家长补助金的目的是调查 上皮-间充质转化中RNA结合蛋白对选择性剪接调控 (EMT)，这是一个与许多类型的疾病有关的发育程序， 纤维化和癌症转移。我们精心制定了培训计划、职业发展计划， 和指导计划，这将提高学生的智力和技术技能，并促进 他的职业发展。研究生将：（1）积极开展论文设计， 了解RNA结合蛋白如何调节剪接和翻译干扰， EMT;（2）接受广泛的实验和计算培训;（3）获得合作， 领导技能;（4）提交博士前奖学金;（5）产生研究成果， 参与在同行评审期刊上发表的写作;（6）参加并出席科学 会议.