R35 Admin Diversity Supplement: Regulation of alternative splicing during epithelial-mesenchymal transition

摘要

ABSTRACT The goal of this supplement is to support research training and career development of a Diversity graduate student in Dr. Chonghui Cheng’s laboratory. The goal of the parent grant is to investigate the regulation of alternative splicing by RNA binding proteins in epithelial-mesenchymal transition (EMT), a developmental program that is associated with many types of diseases, including tissue fibrosis and cancer metastasis. We have carefully crafted training plan, career development plan, and mentoring plan that will enhance the student’s intellectual and technical skills and facilitate his career development. The graduate student will: (1) Actively conduct his thesis project towards understanding how RNA binding protein regulated splicing and translation intertwine to control EMT; (2) Receive extensive experimental and computational trainings; (3) Gain collaboration and leadership skills; (4) Submit predoctoral fellowships; (5) Generate research findings and participate in writing for publication in peer-reviewed journals; (6) Attend and present in Scientific meetings.