The Asia-Pacific HIV Observational Database (APHOD)

亚太艾滋病毒观察数据库 (APHOD)

• 批准号: 7667404
• 负责人: DAVID A COOPER
• 金额: $ 126.58万
• 依托单位: FOUNDATION FOR AIDS RESEARCH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-15 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7667404
• 关键词: AIDS education/prevention; Acquired Immunodeficiency Syndrome; Address; Adverse effects; Affect; Age; Anti-Retroviral Agents; Asia; Asians; Australia; Behavior; Caring; Caucasians; Caucasoid Race; Cause of Death; Characteristics; China; Clinical; Clinics and Hospitals; Code; Data; Data Collection; Data Set; Databases; Developed Countries; Developing Countries; Development; Disease; Disease Outcome; Disease Progression; Drug usage; Economic Development; Economics; Electronics; Epidemic; Epidemiology; Ethnic Origin; Event; Far East; Foundations; HIV; HIV Infections; Health; Hepatitis C; High Prevalence; Highly Active Antiretroviral Therapy; Hodgkin Disease; Home environment; Immune; Immune response; Immune system; Incidence; Individual; Infection; International; Life; Location; Long-Term Effects; Methods; Natural History; Nucleosides; Observational Study; Opportunistic Infections; Outcome; Patients; Pharmaceutical Preparations; Pharmacology; Population; Process; Records; Research Personnel; Reverse Transcriptase Inhibitors; Risk; Site; Social Conditions; South Australia; Therapeutic Human Experimentation; Toxic effect; Training; Treatment Protocols; Treatment outcome; Tuberculosis; base; cohort; combat; cost efficient; disease natural history; latent infection; meetings; reconstitution; response; standard of care; success; treatment planning; treatment response; treatment site; trend; tuberculosis treatment

DESCRIPTION (provided by applicant): Much that informs HIV disease and its treatment is derived from the developed world, mainly Caucasian populations. However, in many important respects HIV infection in Asia differs from other regions. The epidemiology of HIV infection is different, including large injecting drug use epidemics. Co-infection rates with hepatitis C and B are substantial. The natural history of HIV infection differs with faster progression rates and a different spectrum of opportunistic infections. There is emerging evidence that the pharmacology and toxicity of antiretroviral (ARV) treatments in Asian populations are different. Combined with differences such as ethnicities and economic development, and the coincident rapid expansion of ARV treatment access, the study of HIV disease and treatment in Asian populations is imperative. This study seeks to examine HIV disease natural history and treatment in Asia, and to assess differences with Caucasian populations. Specific studies will look at the efficacy and toxicity of ARV treatments. Studies of HIV and tuberculosis (TB), including HIV and TB treatment interactions, and immune reconstitution disease will be an important focus. The long-term effects of ARV treatments will be assessed, including trends in causes of death and comparisons with an age and behavior-matched HIV-negative group. The Asia-Pacific HIV Observational Database combines the TREAT Asia HIV Observational Database and the Australian HIV Observational Database, two established studies covering 39 sites in South, South East and East Asia and Australia, and following some 1750 individuals in Asia and 2329 in Australia. Both studies are observational, collecting demographic, treatment, disease outcome and toxicity data. A particular strength is having toxicity and outcome data collected and coded according to identical methods in Asia and Australia, allowing straightforward comparison of Asian and Caucasian populations. Both studies use an electronic transfer method of data collection that has demonstrated to be highly cost efficient while meeting stringent levels of data accuracy. Relevance: Asia (excluding China) is home to over one third of the world's population, and in 2005 some 7 million people living with HIV. It is known that in many important respects HIV epidemiology, natural history and ARV treatment outcomes differ in Asia compared with other regions. Simultaneously, ARV treatment is rapidly expanding. The Asia-Pacific HIV Observational Database aims to examine HIV disease natural history and treatment in Asia, and compare outcomes with Caucasian populations, principally in Australia, to inform optimal care and treatment for HIV disease in the region.

描述（由申请人提供）：许多关于艾滋病毒疾病及其治疗的信息都来自发达国家，主要是白种人。然而，亚洲的艾滋病毒感染在许多重要方面与其他地区不同。 HIV感染的流行病学各不相同，包括大规模的注射吸毒流行。丙型肝炎和乙型肝炎的合并感染率很高。 HIV 感染的自然史因进展速度较快和机会性感染的范围不同而有所不同。越来越多的证据表明，抗逆转录病毒（ARV）治疗在亚洲人群中的药理学和毒性是不同的。考虑到种族和经济发展等差异，以及抗逆转录病毒治疗机会的迅速扩大，对亚洲人群艾滋病毒疾病和治疗的研究势在必行。本研究旨在研究亚洲的艾滋病毒疾病自然史和治疗方法，并评估与白人人群的差异。具体研究将着眼于抗逆转录病毒治疗的功效和毒性。 HIV 和结核病 (TB) 的研究，包括 HIV 和结核病治疗相互作用以及免疫重建疾病将是一个重要焦点。将评估抗逆转录病毒治疗的长期效果，包括死亡原因的趋势以及与年龄和行为匹配的艾滋病毒阴性群体的比较。亚太艾滋病毒观察数据库结合了 TREAT 亚洲艾滋病毒观察数据库和澳大利亚艾滋病毒观察数据库，这两项既定研究覆盖南亚、东南亚、东亚和澳大利亚的 39 个地点，跟踪了亚洲约 1750 名个人和澳大利亚约 2329 名个人。这两项研究都是观察性的，收集人口统计、治疗、疾病结果和毒性数据。一个特别的优势是在亚洲和澳大利亚按照相同的方法收集和编码毒性和结果数据，从而可以直接比较亚洲人和白人人口。这两项研究均采用电子传输数据收集方法，事实证明该方法具有极高的成本效益，同时满足严格的数据准确性水平。相关性：亚洲（不包括中国）拥有世界三分之一以上的人口，2005 年约有 700 万艾滋病毒感染者。众所周知，亚洲的艾滋病毒流行病学、自然史和抗逆转录病毒治疗结果在许多重要方面与其他地区有所不同。与此同时，抗逆转录病毒治疗正在迅速扩大。亚太艾滋病毒观察数据库旨在研究亚洲艾滋病毒疾病的自然史和治疗，并将结果与​​高加索人群（主要是澳大利亚）进行比较，以便为该地区艾滋病毒疾病的最佳护理和治疗提供信息。