The Asia-Pacific HIV Research Collaboration

亚太艾滋病毒研究合作组织

• 批准号: 8301518
• 负责人: DAVID A COOPER
• 金额: $ 264.82万
• 依托单位: FOUNDATION FOR AIDS RESEARCH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8301518
• 关键词: Acquired Immunodeficiency Syndrome; Adherence; Adolescent; Adult; Affect; Anti-Retroviral Agents; Area; Asia; Asians; Australia; Automobile Driving; Behavioral; Cardiovascular Diseases; Caring; Caucasians; Caucasoid Race; Centers for Disease Control and Prevention (U.S.); Cessation of life; Child; China; Chinese People; Chronic; Chronic Disease; Clinical; Clinical Management; Cohort Studies; Collaborations; Country; Data; Data Collection; Databases; Development; Diabetes Mellitus; Disease; Drug resistance; Drug usage; Drug user; Epidemic; Epidemiologic Studies; Epidemiology; Event; Failure; Future; Goals; Guidelines; HIV; HIV drug resistance; Health Insurance; Healthcare Systems; Hepatitis B; Home environment; Human Papillomavirus; Hypertension; Incidence; Infection; Injection of therapeutic agent; Institution; Kidney Failure; Knowledge; Lead; Life; Liver Failure; Malignant Neoplasms; Modeling; Monitor; Multiregional Analyses; Outcome; Outcome Study; Patients; Pattern; Pediatric Research; Pharmaceutical Preparations; Pharmacology; Population; Populations at Risk; Practice Management; Prevention; Principal Investigator; Publishing; Regimen; Registries; Research; Research Activity; Resources; Risk; Risk Factors; Screening procedure; Site; Surveillance Program; Taiwan; Thailand; Toxic effect; Treatment outcome; Tuberculosis; cancer risk; cohort; data registry; disorder prevention; evidence base; high risk; improved; innovation; interest; male; men who have sex with men; mortality; national surveillance; novel; pediatric human immunodeficiency virus; programs; prospective; response; sex; social; socioeconomics; success; treatment program

DESCRIPTION (provided by applicant): The epidemiology of HIV in the Asia-Pacific region reflects local drivers of infection (e.g., male-to-male sex, injection drug use), key co-infections that impact treatment outcomes (e.g., hepatitis B and 0, tuberculosis), and a range of treatment access and national resource levels. In addition, emerging evidence suggests that the pharmacology and toxicity of antiretroviral drugs in Asian populations are significantly different from Caucasian patients, which could impact long-term treatment tolerability and success. The overall goal of the Asia-Pacific HIV Research Collaboration is to evaluate the impact of HIV disease, co-infections, and ART management on clinical outcomes in the region. Research builds on existing scientific capacity for both broad regional and multiregional analyses and targeted studies on specific outcomes of interest within at-risk populations. The core research relies upon data from the Asia-Pacific HIV Observational Database (APHOD), comprised of the TREAT Asia HIV Observational Database (TAHOD) and the Australian HIV Observational Database (AHOD). Core research also includes the TREAT Asia Pediatric HIV Observational Database (TApHOD). These three established cohorts include data from 60 clinical centers at 54 institutions in 14 South, Southeast and East Asian countries and Australia. A separate collaboration with the National Center for AIDS/STD Control and Prevention (NCAIDS), China CDC, will conduct epidemiologic studies using the China National ART Database, a national surveillance program. Data collection will expand current studies in several innovative areas, with specific aims looking at factors driving the epidemic, as well as the response to ART, impact of co-infections, toxicity of first- and second-line regimens, cancer risk, chronic AIDS- and non-AIDS-related events and outcomes, drug resistance patterns, and cultural and behavioral factors affecting patient management and outcomes. The inclusion of research sites from a wide variety of geographic and socio-economic settings will continue to strengthen the existing adult and pediatric research networks. Successful implementation of these studies will build up an evidence base to inform HIV clinical management practices and programs, advise national and regional treatment guidelines, and add to global understanding of the epidemiology of HIV. RELEVANCE: Published findings on short- and long-term HIV treatment outcomes will lead to more effective, evidence- based clinical management practices for HIV-infected adults and children in the Asia-Pacific region. Identifying risk factors for cancer will help guide future prevention and screening efforts. Participating sites will gain capacity to expand local and regional research activities to better understand the epidemiology of HIV.

描述(由申请人提供)： 亚太区域艾滋病毒的流行病学反映了感染的当地驱动因素(例如，男性对男性、注射吸毒)、影响治疗结果的关键混合感染(例如，乙肝和0型肝炎、结核病)以及一系列治疗机会和国家资源水平。此外，新出现的证据表明，亚洲人群中抗逆转录病毒药物的药理和毒性与高加索患者存在显著差异，这可能会影响长期治疗的耐受性和成功率。亚太艾滋病毒研究合作的总体目标是评估艾滋病毒疾病、混合感染和抗逆转录病毒治疗对该地区临床结果的影响。研究建立在现有科学能力的基础上，既可进行广泛的区域和多区域分析，也可对高危人群中感兴趣的具体结果进行有针对性的研究。核心研究依赖于亚太艾滋病毒观测数据库(APHOD)的数据，该数据库由治疗亚洲艾滋病毒观测数据库(TAHOD)和澳大利亚艾滋病毒观测数据库(AHOD)组成。核心研究还包括治疗亚洲儿童艾滋病毒观察数据库(TApHOD)。这三个已建立的队列包括来自14个南亚、东南亚和东亚国家以及澳大利亚的54个机构的60个临床中心的数据。另一个与国家艾滋病/性病预防控制中心中国合作的项目将使用中国国家抗逆转录病毒治疗数据库进行流行病学研究，这是一个国家监测项目。数据收集将扩大当前在几个创新领域的研究，具体目标是着眼于推动疫情的因素，以及对抗逆转录病毒治疗的反应、合并感染的影响、一线和二线方案的毒性、癌症风险、慢性艾滋病和非艾滋病相关事件和结果、耐药性模式以及影响患者管理和结果的文化和行为因素。纳入各种地理和社会经济环境的研究地点将继续加强现有的成人和儿科研究网络。这些研究的成功实施将建立一个证据基础，为艾滋病毒临床管理实践和方案提供信息，为国家和地区治疗指南提供建议，并增进全球对艾滋病毒流行病学的了解。 相关性： 发表的关于艾滋病毒短期和长期治疗结果的研究结果将为亚太地区感染艾滋病毒的成人和儿童带来更有效、更循证的临床管理做法。识别癌症的风险因素将有助于指导未来的预防和筛查工作。参与网站将获得扩大地方和区域研究活动的能力，以更好地了解艾滋病毒的流行病学。