American College of Radiology Imaging Network

美国放射学院影像网络

• 批准号: 7627986
• 负责人: MITCHELL D. SCHNALL
• 金额: $ 889.64万
• 依托单位: AMERICAN COLLEGE OF RADIOLOGY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-06 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627986
• 关键词: American College of Radiology Imaging Network; Anatomy; Biological Markers; Biometry; Cancer Detection; Clinical; Clinical Trials; Communities; Detection; Development; Diagnosis; Effectiveness; Genetic; Grant; Image; Institution; Intervention; Leadership; Malignant Neoplasms; Measures; Methods; Molecular Biology; Monitor; Pathway interactions; Patients; Physicians; Physiology; Play; Populations at Risk; Prevention; Preventive Intervention; Research; Research Personnel; Role; Specialist; Techniques; Technology; Universities; Work; anticancer research; base; bioimaging; cancer care; cancer imaging; cancer therapy; improved; prognostic; response; tumor

A growing understanding of the multiple genetic and environmental pathways that contribute to the development of cancer is leading to the concept of a personalized approach to cancer therapy and prevention. This requires techniques to characterize patient and tumor factors that will drive specific targeted interventions and measure their effectiveness. Biomedical imaging now offers the opportunity to characterize tumor anatomy, physiology, and molecular biology in unprecedented ways. The challenge is to harness this technology to develop quantitative approaches to diagnosis that will support the development and application of targeted treatments and preventive interventions. Since its inception, ACRIN has developed and implemented multicenter clinical trials to establish the effectiveness of imaging in the detection, characterization and monitoring of cancer. Working with its biostatistics center at Brown University, ACRIN has assembled a unique organization of hundreds of clinical imaging specialists, other clinicians, and non-physician researchers at more than a hundred institutions nationally and internationally working collaboratively with the broader cancer research community dedicated to cancer imaging research. Over the next grant cycle, ACRIN proposes 3 major scientific objective related to the theme of personalized cancer care: 1. targeted surveillance of at-risk populations; 2.characterization of cancer in order to drive targeted therapy; and 3. development of imaging-based predictive and prognostic biomarkers of response to targeted treatment. Through its continued leadership in the imaging community, ACRIN will play a pivotal role in the advancement of cancer detection and therapy. ACRIN will work to discover ways for imaging to improve cancer care. This includes determining the optimal methods to detect cancer early in order to provide the best opportunity for cure, and establishing techniques to characterize cancer and its response to treatment in order to choose the most appropriate therapy.

对多种遗传和环境途径的了解不断加深 癌症的发展催生了个性化癌症治疗方法的概念， 预防。这需要技术来表征患者和肿瘤因素，这些因素将驱动特定的 有针对性的干预措施并衡量其有效性。生物医学成像现在提供了机会 以前所未有的方式描述肿瘤解剖学、生理学和分子生物学的特征。挑战在于 利用这项技术开发定量诊断方法，以支持发展 以及针对性治疗和预防性干预措施的应用。自成立以来，ACRIN 已 开发并实施多中心临床试验，以确定影像学在临床中的有效性 癌症的检测、表征和监测。与布朗大学生物统计中心合作 ACRIN 大学组建了一个由数百名临床影像专家、其他专家组成的独特组织 国内外一百多个机构的临床医生和非医生研究人员 与致力于癌症成像研究的更广泛的癌症研究界合作。 在下一个资助周期中，ACRIN 提出了与个性化主题相关的 3 个主要科学目标 癌症护理： 1. 对高危人群进行有针对性的监测； 2. 癌症特征分析以驱动 靶向治疗； 3. 开发基于成像的预测和预后生物标志物 针对性治疗。通过其在成像领域的持续领导地位，ACRIN 将发挥关键作用 在癌症检测和治疗的进步中发挥着重要作用。 ACRIN 将致力于探索成像方法来改善癌症护理。这包括确定最佳 早期发现癌症的方法，以便提供最佳的治愈机会，并建立技术 描述癌症及其对治疗的反应，以便选择最合适的治疗方法。