Research Core Center---Neuroplasticity of Alcohol Addiction

研究核心中心---酒精成瘾的神经可塑性

• 批准号: 7859324
• 负责人: Peter W Kalivas
• 金额: $ 38.48万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7859324
• 关键词: Agreement; Alcohol dependence; Alcoholism; Alcohols; Applications Grants; Appointment; Basic Science; Behavioral; Behavioral Sciences; Biomedical Research; Brain; Chronic; Clinical; Communities; Consumption; Dependence; Development; Disease; Drug Addiction; Drug Exposure; Environment; Faculty; Funding; Funding Mechanisms; Glutamates; Heavy Drinking; Individual; Institution; Knowledge; Lead; Leadership; Learning; Medical; Medical Education; Memory; Mentors; Mission; Molecular; Monitor; Neuronal Plasticity; Neurosciences; Physical Dependence; Plant Roots; Positioning Attribute; Process; Psychiatry; Recording of previous events; Recovery; Recruitment Activity; Relapse; Request for Applications; Research; Research Personnel; Research Project Grants; Resources; South Carolina; Structure; Substance Withdrawal Syndrome; Substance abuse problem; Synapses; Synaptic plasticity; Therapeutic; Universities; addiction; alcohol behavior; alcohol consequences; alcohol craving; alcohol exposure; alcohol research; alcohol seeking behavior; base; career; career development; chronic alcohol ingestion; cost; drinking; experience; interest; member; multidisciplinary; pre-clinical research; professor; public health relevance; ranpirnase; response; social; tool

DESCRIPTION (provided by applicant): This grant proposal is being submitted in response to RFA-OD-09-005 that uses the P30 Biomedical Core Center funding mechanism to support the hiring of a newly-recruited faculty member whose research will augment and expand the research capacity of the institution's existing research community. The proposal seeks support to hire an identified Faculty Candidate who will join an interactive and multidisciplinary group of researchers at the Medical University of South Carolina (MUSC) who are currently investigating the plasticity of alcohol addiction and dependence. MUSC has had a long-standing commitment to medical education about the broad negative consequences of alcohol/drug addiction, and a rich and diverse history of clinical as well as preclinical research in alcohol and substance abuse related problems. Alcoholism is a chronic relapsing disorder. Prolonged exposure to alcohol is associated with the development of tolerance and dependence, and alcohol addiction is characterized by craving for alcohol and compulsive alcohol-seeking behavior that often leads to excessive and harmful levels of drinking. Accumulating evidence suggests that these behavioral manifestations of the addiction process likely reflect neuroadaptive changes that are rooted in the plasticity of learning and memory. The proposed new faculty hire will augment and expand the research capabilities of the neuroplasticity Alcohol Core Center (ACC) group at MUSC. The ACC group of investigators at MUSC is actively engaged in numerous multidisciplinary and collaborative research projects. Thus, the new faculty member will be immersed in a highly supportive and productive academic environment with many prominent researchers in the addiction neuroscience field. The specific aims of this proposal are as follows. Aim 1 is to successfully recruit a highly promising and productive junior alcohol researcher into a tenure-track Assistant Professor position. Aim 2 is to provide an appropriate mentoring and research environment for the successful career development of the Faculty Candidate as an alcohol researcher. Aim 3 is to augment and expand the capability of the ACC in the neuroplasticity of alcohol dependence and addiction. PUBLIC HEALTH RELEVANCE: Alcohol is a widely abused substance with tremendous personal, financial and social costs. The hiring of a new research faculty to augment the development of an Alcohol Core Center to study how alcohol exposure leads to changes in brain function that underlies this disorder may lead to the development of effective therapeutic treatments.

描述(由申请人提供)：本资助提案是为了响应RFA-OD-09-005的要求而提交的，RFA-OD-09-005使用P30生物医学核心中心的资助机制来支持雇用一名新招聘的教员，其研究将增强和扩大该机构现有研究团体的研究能力。该提案寻求支持聘请一名确定的学院候选人，他将加入南卡罗来纳医科大学(MUSC)的一个互动和多学科研究小组，该小组目前正在研究酒精成瘾和依赖的可塑性。MUSC长期以来一直致力于医学教育，即酒精/药物成瘾的广泛负面后果，以及与酒精和药物滥用相关的问题的丰富和多样化的临床和临床前研究历史。酗酒是一种慢性复发性障碍。长期接触酒精与形成耐受性和依赖性有关，酒精成瘾的特征是对酒精的渴望和强迫性饮酒行为，这往往会导致过度和有害的饮酒水平。越来越多的证据表明，成瘾过程的这些行为表现可能反映了植根于学习和记忆可塑性的神经适应性变化。拟议的新教师招聘将增强和扩大加州大学圣迭戈分校神经可塑性酒精核心中心(ACC)小组的研究能力。南加州大学行政协调会调查组积极参与许多多学科和协作研究项目。因此，这位新教员将沉浸在一个高度支持和富有成效的学术环境中，与许多成瘾神经科学领域的知名研究人员在一起。这项建议的具体目标如下。目标1是成功招聘一名非常有前途和多产的初级酒精研究人员，进入终身教职轨道的助理教授职位。目标二是为学院候选人作为一名酒精研究人员的成功职业发展提供适当的指导和研究环境。目的3是增强和扩大ACC在酒精依赖和成瘾的神经可塑性中的能力。 与公共健康相关：酒精是一种被广泛滥用的物质，会给个人、经济和社会带来巨大的代价。聘请新的研究人员来加强酒精核心中心的发展，以研究酒精暴露如何导致大脑功能的变化，从而导致这种疾病，可能会导致有效的治疗方法的开发。