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Putting Electrospun Nanofibers to Work for Musculoskeletal Research

将静电纺丝纳米纤维用于肌肉骨骼研究

基本信息

批准号：
7680843
负责人：
YOUNAN XIA
金额：
$ 7.56万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-11 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7680843
关键词：
Animal Model Animals Area Biocompatible Biological Assay Biology Biomechanics Biomedical Engineering Biomedical Research Bone Marrow Bone Regeneration Bone neoplasms Caliber Cartilage Cell Culture Techniques Cell Differentiation process Cell-Matrix Junction Cells Cellular Morphology Chemistry Clinical Defect Degenerative polyarthritis Engineering Enzymes Extracellular Matrix Extracellular Matrix Proteins Fiber Fibroblasts Film Funding Future Glycolates Goals Growth Factor Healed Hydroxyapatites In Vitro Injury Mechanics Medicine Mesenchymal Stem Cells Minerals Musculoskeletal Nutrient One-Step dentin bonding system Orthopedic Surgery procedures Orthopedics Performance Porosity Positioning Attribute Process Property Rattus Recurrence Research Research Personnel Rotator Cuff Shoulder Site Solid Solutions Structure Surface System Tendon structure Testing Tissue Engineering Tissues Transportation Universities Washington Work Wound Healing biodegradable polymer bone clinically relevant controlled release copolymer design healing in vivo nanofiber repaired research study scaffold skeletal supraspinatus muscle targeted delivery

项目摘要

This project is a collaborative effort involving investigators from the Departments of Biomedical Engineering and Orthopaedic Surgery at Washington University in St. Louis. The main goal of this project is to develop and validate electrospun nanofibers as a new platform for musculoskeletal research, with an initial focus on the demonstration of scaffolds for tissue repairing at the tendon-to-bone insertion site. In this project, we will fabricate nanofibers by electrospinning and then optimize their use as scaffolds for tissue engineering by in vitro cell culture studies. We will then evaluate the performance of these nanofibrous scaffolds in vivo using a clinical-relevant animal model for the repair of supraspinatus tendon at the insertion site.

这个项目是一个合作的努力，涉及来自生物医学工程系的研究人员和圣路易斯华盛顿大学的矫形外科。该项目的主要目标是开发并验证电纺纳米纤维作为肌肉骨骼研究的新平台，最初的重点是在肌腱-骨插入部位的组织修复支架的演示。在这个项目中，我们将通过静电纺丝制备纳米纤维，然后通过在组织工程中优化其作为支架的用途，体外细胞培养研究。然后，我们将评估这些纳米纤维支架在体内的性能，使用临床相关的动物模型，用于在插入部位修复冈上肌腱。