Putting Electrospun Nanofibers to Work for Musculoskeletal Research

这个项目是一个合作的努力，涉及来自生物医学工程系的研究人员 和圣路易斯华盛顿大学的矫形外科。该项目的主要目标是开发 并验证电纺纳米纤维作为肌肉骨骼研究的新平台，最初的重点是 在肌腱-骨插入部位的组织修复支架的演示。在这个项目中，我们将 通过静电纺丝制备纳米纤维，然后通过在组织工程中优化其作为支架的用途， 体外细胞培养研究。然后，我们将评估这些纳米纤维支架在体内的性能，使用 临床相关的动物模型，用于在插入部位修复冈上肌腱。

This project is a collaborative effort involving investigators from the Departments of Biomedical Engineering and Orthopaedic Surgery at Washington University in St. Louis. The main goal of this project is to develop and validate electrospun nanofibers as a new platform for musculoskeletal research, with an initial focus on the demonstration of scaffolds for tissue repairing at the tendon-to-bone insertion site. In this project, we will fabricate nanofibers by electrospinning and then optimize their use as scaffolds for tissue engineering by in vitro cell culture studies. We will then evaluate the performance of these nanofibrous scaffolds in vivo using a clinical-relevant animal model for the repair of supraspinatus tendon at the insertion site.