Putting Electrospun Nanofibers to Work for Musculoskeletal Research

这个项目是由生物医学工程系的研究人员共同参与的。 和圣路易斯华盛顿大学的整形外科。这个项目的主要目标是开发 并验证电纺纳米纤维作为肌肉骨骼研究的新平台，最初的重点是 肌腱-骨附着点组织修复支架的演示。在这个项目中，我们将 通过静电纺丝制备纳米纤维，然后通过在组织工程中 体外细胞培养研究。然后我们将评估这些纳米纤维支架在体内的性能 冈上肌腱止点修复的临床相关动物模型。

This project is a collaborative effort involving investigators from the Departments of Biomedical Engineering and Orthopaedic Surgery at Washington University in St. Louis. The main goal of this project is to develop and validate electrospun nanofibers as a new platform for musculoskeletal research, with an initial focus on the demonstration of scaffolds for tissue repairing at the tendon-to-bone insertion site. In this project, we will fabricate nanofibers by electrospinning and then optimize their use as scaffolds for tissue engineering by in vitro cell culture studies. We will then evaluate the performance of these nanofibrous scaffolds in vivo using a clinical-relevant animal model for the repair of supraspinatus tendon at the insertion site.