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GOLD NANOCAGES AS A NEW CLASS OF THERAPEUTIC AGENTS FOR PHOTOTHERMAL CANCER TREAT

金纳米笼作为光热癌症治疗的新型治疗剂

基本信息

批准号：
8450128
负责人：
YOUNAN XIA
金额：
$ 36.83万
依托单位：
GEORGIA INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-02-19 至 2014-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8450128
关键词：
2-Fluoro-2-deoxyglucose Acids Address Adverse effects Animal Model Antibodies Biodistribution Biomedical Engineering Cells Chelating Agents Chemistry Clinical Color Contrast Media Copper Coupled Diagnostic Drug resistance Electron Microscopy Evaluation Extravasation Flow Cytometry Fluorescence Fluorine Goals Gold Health Heating Image In Vitro Individual Injury Label Lasers Length Ligands Light Mainstreaming Malignant Neoplasms Mass Spectrum Analysis Measurement Metals Methods Microscopy Modeling Molecular Monitor Morphology Mus Nanostructures Operative Surgical Procedures Optical Coherence Tomography Organ Patients Plasma Positioning Attribute Positron Positron-Emission Tomography Process Production Property Radiation Radiation therapy Radioisotopes Radiology Specialty Radiopharmaceuticals Reaction Research Research Personnel Roentgen Rays Role Silver Site Surface Survival Rate Technology Therapeutic Therapeutic Agents Therapeutic procedure Thick Tissues Transducers Universities Visual Washington Work X-Ray Computed Tomography absorption aqueous base cancer cell cancer therapy chemotherapy cyclen imaging modality improved in vivo in vivo Model killings large scale production nanocage nanoscale novel overexpression programs receptor scale up soft tissue tomography tool tumor tumor metabolism two-photon

项目摘要

DESCRIPTION (provided by applicant): This collaborative program involves investigators from Departments of Biomedical Engineering and Radiology at Washington University in St. Louis. The ultimate goal of this work is to develop and validate Au nanocages with targeting ligands as a novel class of therapeutic agents, which can serve as nanoscale transducers to effectively convert NIR light into heat and selectively kill cancer cells without any adverse side effects. The scope of this research includes: i) developing robust methods for large-scale production of Au nanocages with controlled size, wall thickness, absorption cross section, and surface functionality; ii) understanding the in vitro targeting capability and the role of Au nanocages in photothermal destruction of cancer cells; iii) assessing the biodistribution of PEGylated Au nanocages and maximizing their capability for passive targeting of tumor in an animal model; iv) developing Au nanocages with the right size and surface chemistry for a combination of passive and active tumor targeting in an animal model; and v) validating and optimizing the use of functionalized Au nanocages for photothermal destruction of tumor in an animal model. If successful, the technology to be developed in this application will provide a highly effective and selective method for cancer treatment. By varying the ratio of absorption to scattering cross section, the functionalized Au nanocages could also serve as molecular contrast agents for a number of imaging modalities, including optical coherence tomography (OCT), photoacoustic tomography (PAT), two-photon fluorescence, as well as CT (because Au is also a strong absorber of X-ray). As a result, Au nanocages have the potential to become a novel class of dual agents for both diagnostic and therapeutic applications

描述（由申请人提供）：该合作项目涉及圣路易斯华盛顿大学生物医学工程和放射学系的研究人员。这项工作的最终目标是开发和验证具有靶向配体的Au纳米笼作为一类新型治疗剂，其可以作为纳米级换能器，有效地将NIR光转化为热，并选择性地杀死癌细胞，而没有任何不良副作用。本研究的范围包括：i）开发用于大规模生产具有可控尺寸、壁厚、吸收截面和表面功能的Au纳米笼的稳健方法; ii）了解体外靶向能力和Au纳米笼在光热破坏癌细胞中的作用; iii）评估PEG化Au纳米笼的生物分布并使其在动物模型中被动靶向肿瘤的能力最大化; iv）开发具有合适尺寸和表面化学的Au纳米笼，用于在动物模型中组合被动和主动肿瘤靶向;和v）验证和优化功能化Au纳米笼用于在动物模型中光热破坏肿瘤的用途。如果成功的话，这项应用中开发的技术将为癌症治疗提供一种高效和选择性的方法。通过改变吸收与散射截面的比率，官能化的Au纳米笼还可以用作用于许多成像模态的分子造影剂，包括光学相干断层扫描（OCT）、光声断层扫描（PAT）、双光子荧光以及CT（因为Au也是X射线的强吸收剂）。因此，Au纳米笼有可能成为一类新型的诊断和治疗双重试剂