RC2 - The Vulnerable Aging Research Core (VARC)

项目总结摘要-脆弱老化研究核心（VARC） 脆弱老龄化研究核心（VARC）支持OAIC调查人员进行主要数据收集 包括脆弱的老年人的研究。老年人在研究中的代表性严重不足。这 对于具有医疗脆弱性的老年人来说，代表性不足甚至更明显（例如，认知 缺陷和复杂的多种疾病）和/或社会脆弱性（例如，孤独、贫穷、健康有限 无家可归）。这些医疗和社会脆弱性往往共存，相互作用， 对疾病发生率、进展、结果和对卫生干预措施的反应产生深远影响。然而， 有这些脆弱性的成年人往往难以征聘和留住，对他们的代表性产生不利影响 在研究和削弱我们的知识，如何最好地优化他们的照顾。加州大学旧金山分校胡椒中心有一个 在招募、保留和保护医疗和社会福利人员方面享有国际声誉 弱势老年人的研究，包括在社区参与的研究，前瞻性研究， 随机试验自上个周期VARC成立以来， 医疗和社会弱势老年人的数据收集继续呈指数增长， 我们为调查人员提供的服务。我们提出以下目标：（1）提供专家咨询， 主要数据收集研究的设计，重点是老年人的医疗和/或社会 脆弱性，包括人类受试者的考虑;（2）支持OAIC附属调查人员的方法 招募、同意、登记和留住弱势老年人，包括召集和维持 （3）支持OAIC调查人员制定和测试干预措施的方法， 对弱势老年人的需求和优先事项作出反应;（4）建议将 医疗和社会脆弱性的预测和结果指标（例如，认知障碍，虚弱，健康 （5）与数据和分析中心合作， 开发项目，推进我们核心主题领域新方法的开发。我们 提出一个新的发展项目，以开发创新的方法，合并定性和混合 方法数据跨研究涉及老年人与残疾和他们的护理伙伴和临床医生。的 VARC还将支持恒星外部调查人员的研究涉及招聘和保留 脆弱的老年人。拟议的外部项目包括由国家情报局资助的研究， 老年痴呆症和相关痴呆症患者的社会支持服务以及 一种新的决策支持工具，帮助老年人与临床医生讨论糖尿病药物处方。

PROJECT SUMMARY ABSTRACT — Vulnerable Aging Research Core (VARC) The Vulnerable Aging Research Core (VARC) supports OAIC investigators conducting primary data collection studies that include vulnerable older adults. Older adults are vastly underrepresented in research. This underrepresentation is even more pronounced for older adults with medical vulnerability (e.g., cognitive impairment and complex multi-morbidity) and/or social vulnerability (e.g., isolation, poverty, limited health literacy, homelessness). These medical and social vulnerabilities often coexist and interact to produce profound effects on disease incidence, progression, outcomes, and response to health interventions. Yet, older adults with these vulnerabilities are often difficult to recruit and retain, adversely affecting their representation in research and impairing our knowledge of how best to optimize their care. The UCSF Pepper Center has an international reputation for expertise in the recruitment, retention, and protection of medically and socially vulnerable older adults in research including in community-engaged research, prospective studies, and randomized trials. Since the VARC's inception last cycle, the number of OAIC investigators engaged in primary data collection of medically and socially vulnerable older adults has continued to grow exponentially, as have the services we provide to investigators. We propose the following aims: (1) Provide expert consultation for the design of primary data collection studies that focus on older adults with medical and/or social vulnerabilities, including human subject considerations; (2) Support OAIC-affiliated investigators on methods for recruiting, consenting, enrolling, and retaining vulnerable older adults, including convening and maintaining community advisory boards; (3) Support OAIC investigators on methods to develop and test interventions that are responsive to the needs and priorities of vulnerable older adults; (4) Advise on the incorporation of predictor and outcome measures of medical and social vulnerability (e.g., cognitive impairment, frailty, health literacy, poverty, social isolation) in collaboration with the Data and Analysis Core; and (5) Support Development Projects that advance the development of new methodologies in our Core's theme area. We propose a novel Development Project to develop innovative methods for merging qualitative and mixed methods data across studies involving older adults with disability and their care partners and clinicians. The VARC will also support stellar external investigators whose research involves recruiting and retaining vulnerable older adults. Proposed external projects include NIA-funded studies exploring barriers to long-term social support services for older adults with Alzheimer's Disease and Related Dementias and the effects of a novel decision support tool to help older adults discuss diabetes medication deprescribing with clinicians.