VARC Core

脆弱老龄化招募和保留核心（VARC） 老年人在研究中的代表性严重不足。这种代表性不足的情况在以下国家更为明显： 具有医疗脆弱性的老年人（例如，认知障碍和复杂的多种疾病）和/或社会 脆弱性（例如，孤立、贫穷、识字有限或无家可归）。这些医疗和社会的脆弱性 通常共存并相互作用，对疾病的发生率、进展、结局和 对卫生干预措施的反应。然而，有这些脆弱性的老年人往往很难招募， 保留，对他们在研究中的代表性产生不利影响，并损害我们对如何最好地优化 他们的照顾。加州大学旧金山分校老年医学部在招聘方面的专业知识在国际上享有盛誉， 研究中的弱势老年人的保留和保护，包括纵向队列和随机 审判在我们的第一个周期，加州大学旧金山分校老年人独立中心（OAIC）大大扩大了其支持， 招募和保留弱势老年人在加州大学旧金山分校。为了在这一进展的基础上再接再厉， 随着对我们专业知识需求的增加，我们建议创建一个专门的核心：脆弱的老龄化 招聘和保留核心（VARC）。我们提出以下目标： 1)为设计提供专家咨询（例如，飞行员，纵向队列，有效性和实用性 试验）和机构审查委员会对主要数据收集研究的考虑， 有医疗和/或社会脆弱性的成年人; 2)支持OAIC调查人员招募、登记和留住弱势老年人的方法， 包括适当的知情同意程序和设立社区咨询委员会; 3)建立行政、指导和教育资源，以培训OAIC附属研究人员和工作人员 关于招募、登记和弱势群体同意的后勤工作; 4)建议纳入医疗脆弱性的预测和结果指标（例如，认知 损伤、虚弱）和社会脆弱性（例如，卫生知识普及、贫穷、社会孤立等）合作 数据和分析核心。 5)支持发展项目，创造新的方法，以改善招聘和保留 脆弱的老年人进行研究。

Project Summary: The Vulnerable Aging Recruitment and Retention Core (VARC) Older adults are vastly underrepresented in research. This underrepresentation is even more pronounced for older adults with medical vulnerability (e.g., cognitive impairment and complex multi-morbidity) and/or social vulnerability (e.g., isolation, poverty, limited literacy or homelessness). These medical and social vulnerabilities often coexist and interact to produce profound effects on disease incidence, progression, outcomes, and response to health interventions. Yet older adults with these vulnerabilities are often difficult to recruit and retain, adversely affecting their representation in research and impairing our knowledge of how best to optimize their care. The UCSF Division of Geriatrics has an international reputation for expertise in the recruitment, retention, and protection of vulnerable older adults in research including in longitudinal cohorts and randomized trials. In our first cycle, the UCSF Older Adults Independence Center (OAIC) greatly expanded its support of the recruitment and retention of vulnerable older adults across UCSF. To build on this progress and meet the increased demand for our expertise, we propose to create a dedicated core: The Vulnerable Aging Recruitment and Retention Core (VARC). We propose the following aims: 1) Provide expert consultation for the design (e.g., pilots, longitudinal cohorts, and efficacy and pragmatic trials) and Institutional Review Board considerations for primary data collection studies that focus on older adults with medical and/or social vulnerabilities; 2) Support OAIC investigators on methods for recruiting, enrolling, and retaining vulnerable older adults, including appropriate informed consent procedures and the creation of community advisory boards; 3) Establish administrative, mentorship and educational resources to train OAIC-affiliated researchers and staff concerning the logistics of recruitment, enrollment, and consent of vulnerable populations; 4) Advise on the incorporation of predictor and outcome measures of medical vulnerability (e.g., cognitive impairment, frailty) and social vulnerability (e.g., health literacy, poverty, social isolation, etc.) in collaboration with the Data and Analysis Core. 5) Support development projects that create novel methods for improving recruitment and retention of vulnerable older adults into research studies.