HIV Infection in Ethnic Minority IDUs: An International Systematic Review

少数民族注射吸毒者中的艾滋病毒感染：国际系统评价

• 批准号: 7649431
• 负责人: Don C Des Jarlais
• 金额: $ 54.54万
• 依托单位: BETH ISRAEL MEDICAL CTR (NEW YORK)
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7649431
• 关键词: AIDS prevention; AIDS/HIV problem; Accounting; Acquired Immunodeficiency Syndrome; Address; African American; Area; Arts; Asia; Australia; Categories; Code; Communities; Country; Data; Data Set; Developed Countries; Developing Countries; Development; Disadvantaged; Discrimination; Drug usage; Drug user; Epidemic; Epidemiology; Ethnic group; Europe; Frequencies; Future; Geographic Locations; Glare; HIV; HIV Infections; Health Services Needs; Hepatitis C; Heterosexuals; Hispanics; Incidence; Individual; Injecting drug user; Injection of therapeutic agent; International; Intervention; Lead; Learning; Meta-Analysis; Methods; Minority Groups; Modeling; Morbidity - disease rate; North America; Pattern; Population; Prevalence; Procedures; Provider; Public Health; Publishing; Recommendation; Recording of previous events; Reporting; Research; Research Personnel; Risk; Risk Behaviors; Services; Sexual Partners; Sexual Transmission; Sexually Transmitted Diseases; Site; Stigmatization; Time; United States National Institutes of Health; caucasian American; ethnic difference; ethnic minority population; health disparity; innovation; member; mortality; non-drug; prevention service; public health relevance; racial and ethnic; racial/ethnic difference; repository; research study; sex risk; systematic review; transmission process; user-friendly

DESCRIPTION (provided by applicant): Racial/ethnic group disparities in HIV/AIDS are a critical public health issue in the US. These disparities are particularly dramatic with respect to injecting drug use. African-Americans constitute 13% of the US population and 52% of recent US injecting drug use AIDS cases; Hispanics constitute 14% of the US population and 24% of the injecting drug use AIDS cases. These disparities are not the result of more injecting drug users among African-Americans and Hispanics, but of higher rates of HIV infection among African- American and Hispanic IDUs in many areas of the country. Similar disparities-higher rates of HIV infection among ethnic minority IDUs-have also been observed in many foreign countries. Indeed the situation of ethnic minority IDUs in some developing countries can be considered a crisis, with extremely high incidence, prevalence and HIV-related mortality. Disparities have also been observed among non-injecting drug users, with ethnic minority group members having higher rates of HIV infection. The logical next step for addressing these disparities and this epidemiological conundrum is not another individual study, but a systematic review of the large number of relevant studies that have been conducted to date. Our proposed systematic review will use state-of-the-art methods and include the US and the international data on ethnic group differences in HIV infection among drug users. The specific aims include: Developing procedures for combining qualitative and quantitative data from multiple research studies of IDUs in a single geographic area into a "history of the HIV epidemic among IDUs" in that area. Determining the frequency of HIV epidemics in which substantial differences in HIV infection have and have not arisen in ethnic minority IDUs vs. ethnic majority IDUs in the US and internationally. Identifying potential causal factors that may generate substantial differences in HIV prevalence among racial/ethnic minority vs. ethnic majority IDUs. Identifying potential causal factors that may perpetuate or reduce differences in HIV infection among racial/ethnic differences over time. Identifying epidemiologic situations in which differences in HIV risk behaviors do or do not statistically "explain" differences in HIV infection among racial/ethnic groups of IDUs. The research will also create an extremely rich dataset on HIV infection among ethnic drug uses that will be made available for use by other researchers and HIV prevention service providers. The research addresses one of the most important aspects of HIV/AIDS-the frequent large disparities in HIV infection among ethnic groups in the US and in many other countries. The research will be an innovative application of state of the art methods for systematic review, including extensive searching for published and unpublished studies, quantitative coding of research reports, and applying meta-regression/hierarchical modeling to these problems. PUBLIC HEALTH RELEVANCE: Higher rates of HIV infection among African-American and Hispanic IDUs are a major health disparity in the US. African-Americans comprise 13% of the US population and 52% of injection drug use AIDS cases, Hispanics 14% of the populations and 24% of cases. Similar disparities, higher rates of HIV infection among ethnic minority IDUs, have also been observed in many foreign countries. An international systematic review and meta-analysis should greatly advance our understanding of these disparities and suggest how they might be ameliorated.

描述（由申请人提供）：艾滋病毒/艾滋病的种族/族裔群体差异是美国的一个关键公共卫生问题。这些差异在注射吸毒方面尤为显著。非洲裔美国人占美国人口的13%，占美国最近注射吸毒艾滋病病例的52%;西班牙裔美国人占美国人口的14%，占注射吸毒艾滋病病例的24%。这些差异并不是因为非裔美国人和西班牙裔美国人中注射毒品使用者较多，而是因为该国许多地区非裔美国人和西班牙裔美国人注射毒品使用者中艾滋病毒感染率较高。在许多外国也观察到了类似的情况，即少数民族注射吸毒者中艾滋病毒感染率较高。事实上，在一些发展中国家，少数民族注射吸毒者的情况可被视为一种危机，其发病率、流行率和与艾滋病毒有关的死亡率极高。在非注射毒品使用者中也观察到了差异，少数民族群体成员的艾滋病毒感染率较高。解决这些差异和流行病学难题的合理下一步不是另一项单独的研究，而是对迄今为止进行的大量相关研究进行系统评价。我们提出的系统评价将使用最先进的方法，并包括美国和国际数据的种族群体之间的差异，艾滋病毒感染的吸毒者。具体目标包括：制定程序，将对一个地理区域注射吸毒者进行的多项研究的定性和定量数据合并为该地区“注射吸毒者中艾滋病毒流行史”。确定艾滋病毒流行的频率，其中美国和国际上少数族裔注射吸毒者与多数族裔注射吸毒者之间艾滋病毒感染存在和未出现重大差异。查明可能造成少数种族/族裔与多数族裔注射吸毒者之间艾滋病毒流行率显著差异的潜在因果因素。确定可能使不同种族/民族之间的艾滋病毒感染差异长期存在或减少的潜在因果因素。确定艾滋病毒危险行为的差异在统计学上能够或不能“解释”注射吸毒者种族/族裔群体之间艾滋病毒感染差异的流行病学情况。该研究还将创建一个关于少数民族药物使用者艾滋病毒感染的极其丰富的数据集，供其他研究人员和艾滋病毒预防服务提供者使用。这项研究针对的是HIV/AIDS最重要的一个方面--在美国和许多其他国家，不同种族群体之间HIV感染率的巨大差异。该研究将是最先进的系统评价方法的创新应用，包括广泛搜索已发表和未发表的研究，研究报告的定量编码，并将荟萃回归/分层模型应用于这些问题。 公共卫生相关性：非洲裔美国人和西班牙裔注射吸毒者中艾滋病毒感染率较高是美国一个主要的健康差距。非洲裔美国人占美国人口的13%，占注射毒品使用艾滋病病例的52%，西班牙裔占人口的14%，占病例的24%。在许多外国也观察到类似的差异，即少数民族注射吸毒者中艾滋病毒感染率较高。一项国际性的系统性综述和荟萃分析应能极大地促进我们对这些差异的理解，并提出如何改善这些差异的建议。