Maternal Genetic Variation and Risk of Adverse Pregnancy Outcomes

母亲遗传变异和不良妊娠结果的风险

基本信息

项目摘要

DESCRIPTION (provided by applicant): Preterm birth, small-for-gestational age (SGA) and pregnancy induced hypertension (PIH) are major pregnancy complications that impact the health of the mother and the child, often resulting in admission to the neonatal intensive care unit following delivery. We propose a highly efficient, intensive pathway-based analysis of genetic variation and preterm delivery, SGA, and PIH that addresses the following specific aims: (1) To investigate the relationship between polymorphisms in the cell-cycle and apoptosis pathways with risk of preterm delivery, SGA, term SGA and pregnancy induced hypertension (PIH); (2) To investigate the relationship between polymorphisms in the angiogenesis pathway with risk of SGA and PIH; (3) To investigate the relationship between polymorphisms in the inflammation pathway with risk of preterm delivery, total and term SGA, and PIH. To address these aims we will be drawing on a well- characterized prospective cohort study of preterm delivery, the Pregnancy, Infection and Nutrition study (PIN), which enrolled over five thousand women over the course of approximately 10 years. In a nested case-control subset of preterm (n=379), term SGA (n=281, an additional 90 are preterm), and PIH cases (n=468) and a random group of controls (n = 936), DNA has already be extracted and is available for genetic analyses. We propose to analyze these DNA specimens using a haplotype-based approach for approximately 93 genes of interest on the Illumina 1536 chip. The priority pathways we have identified bear relevance to the period of placentation, which is a period of development at which these outcomes may be etiologically linked. With additional investment, this cohort could provide the most comprehensive evidence to date linking variants in these pathways of interest with these adverse birth outcomes. PUBLIC HEALTH RELEVANCE: This study promises to generate a markedly enhanced understanding of the genetic epidemiology of preterm, SGA and PIH. This information will provide a foundation for studying other adverse pregnancy outcomes with shared biological mechanisms.
描述(由申请人提供):早产、小于胎龄(SGA)和妊娠高血压综合征(PIH)是影响母亲和孩子健康的主要妊娠并发症,通常导致分娩后进入新生儿重症监护室。我们提出了一种针对遗传变异和早产、SGA 和 PIH 的高效、密集的基于通路的分析,其具体目标如下:(1)研究细胞周期多态性和细胞凋亡通路与早产、SGA、足月 SGA 和妊娠高血压综合征(PIH)风险之间的关系; (2)探讨血管生成通路多态性与SGA、PIH风险的关系; (3)探讨炎症通路多态性与早产风险、总SGA、足月SGA、PIH的关系。为了实现这些目标,我们将利用一项特征明确的早产前瞻性队列研究,即妊娠、感染和营养研究 (PIN),该研究在大约 10 年的时间里招募了 5000 多名妇女。在早产儿 (n=379)、足月 SGA (n=281,另外 90 例早产儿)、妊娠高血压综合征 (n=468) 和随机对照组 (n=936) 的嵌套病例对照子集中,DNA 已被提取并可用于遗传分析。我们建议使用基于单倍型的方法对 Illumina 1536 芯片上大约 93 个感兴趣的基因进行分析。我们确定的优先途径与胎盘期相关,胎盘期是这些结果可能与病因相关的发育期。通过额外的投资,该队列可以提供迄今为止最全面的证据,将这些感兴趣的途径中的变异与这些不良出生结果联系起来。公共卫生相关性:这项研究有望显着增强对早产儿、SGA 和 PIH 遗传流行病学的了解。这些信息将为研究具有共同生物学机制的其他不良妊娠结局奠定基础。

项目成果

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Stephanie Engel其他文献

Stephanie Engel的其他文献

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{{ truncateString('Stephanie Engel', 18)}}的其他基金

Early Life Phthalate Exposures in Relation to Structural and Functional Brain Development
生命早期接触邻苯二甲酸盐与大脑结构和功能发育的关系
  • 批准号:
    10316345
  • 财政年份:
    2021
  • 资助金额:
    $ 31.94万
  • 项目类别:
5/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) Consortium
5/6 六溴环十二烷产前经历和纵向发展 (PRELUDE) 联盟
  • 批准号:
    10661752
  • 财政年份:
    2021
  • 资助金额:
    $ 31.94万
  • 项目类别:
Early Life Phthalate Exposures in Relation to Structural and Functional Brain Development
生命早期接触邻苯二甲酸盐与大脑结构和功能发育的关系
  • 批准号:
    10469465
  • 财政年份:
    2021
  • 资助金额:
    $ 31.94万
  • 项目类别:
The Vaginal Microbiome and Racial Disparity in Preterm Delivery
阴道微生物组和早产的种族差异
  • 批准号:
    9241046
  • 财政年份:
    2017
  • 资助金额:
    $ 31.94万
  • 项目类别:
Prenatal Toxicant Exposure and Risk of Attention-Deficit Hyperactivity Disorder
产前有毒物暴露和注意力缺陷多动障碍的风险
  • 批准号:
    8538390
  • 财政年份:
    2012
  • 资助金额:
    $ 31.94万
  • 项目类别:
A Pooled Investigation of Prenatal Phthalate Exposure and Childhood Obesity
产前邻苯二甲酸盐暴露与儿童肥胖的综合调查
  • 批准号:
    8575542
  • 财政年份:
    2012
  • 资助金额:
    $ 31.94万
  • 项目类别:
Prenatal Toxicant Exposure and Risk of Attention-Deficit Hyperactivity Disorder
产前有毒物暴露和注意力缺陷多动障碍的风险
  • 批准号:
    8685262
  • 财政年份:
    2012
  • 资助金额:
    $ 31.94万
  • 项目类别:
A Pooled Investigation of Prenatal Phthalate Exposure and Childhood Obesity
产前邻苯二甲酸盐暴露与儿童肥胖的综合调查
  • 批准号:
    8444177
  • 财政年份:
    2012
  • 资助金额:
    $ 31.94万
  • 项目类别:
Prenatal Toxicant Exposure and Risk of Attention-Deficit Hyperactivity Disorder
产前有毒物暴露和注意力缺陷多动障碍的风险
  • 批准号:
    8346378
  • 财政年份:
    2012
  • 资助金额:
    $ 31.94万
  • 项目类别:
Prenatal Toxicant Exposure and Risk of Attention-Deficit Hyperactivity Disorder
产前有毒物暴露和注意力缺陷多动障碍的风险
  • 批准号:
    8856243
  • 财政年份:
    2012
  • 资助金额:
    $ 31.94万
  • 项目类别:

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