CARDIOVASCULAR HEALTH STUDY (CHS)- CORE STUDY OPERATIONS

心血管健康研究(CHS)是一项关于冠心病和中风风险因素的队列研究，以不同人群为基础，对基线年龄在65岁或以上的男性和女性进行研究。主要目标是确定与心脏病和中风的发病和病程相关的因素。最初的5 201名老年人队列是在-1990年招募的；1992-1993年，又招募和检查了687名非洲裔美国人参与者。在基线时，参与者回答了问卷并进行了检查，包括颈动脉超声、超声心动图和肺功能。在1990-1999年的随访中，重复了许多基线检查成分，以及一些新的检查成分，包括颅骨 增加磁共振成像(MRI)检查。社区卫生服务诊所的主要考试于1999年6月结束。2005年又进行了一次检查，目前正在进行家访。自1999年6月以来，每年给参与者打两次电话，确定事件并收集有限的信息，包括住院治疗和关于心血管事件的信息。2005年，当NHLBI停止为活动数据收集和裁决提供资金时，一笔由调查员发起的赠款(HL080295，转化为合作协议)支持这些活动，直到2015年。2015年，当NHLBI停止资助社区卫生服务的基础设施时，一项由调查员发起的赠款(HL130114，转化为合作协议)继续支持与参与者的联系和工作组的支持。本建议书是为响应NHLBI RFP第75N92018R0090号《心血管健康》而写的 研究(CHS)“，旨在将CHS基础设施从合作协议和CHS生物制品储存库(编号01HL268201800001C)转移到单一合同。除了研究结束，两个科学目标是：1)保持CHS作为老年人心血管健康的研究资源；2)采用创新的方法，确保这一基础设施的有效利用。

The Cardiovascular Health Study (CHS) is a cohort study of risk factors for coronary heart disease and stroke in a diverse population-based sample of men and women aged 65 years or older at baseline. The main objective is to identify factors related to the onset and course of heart disease and stroke. The original cohort of 5201 elderly were recruited in 1989-1990; and in 1992-1993, 687 additional African American participants were recruited and examined. At baseline, participants answered questionnaires and were examined, including carotid ultrasound, echocardiography, and pulmonary function. During follow-up, 1990-1999, many baseline examination components were repeated, and a few new ones, including cranial magnetic resonance imaging (MRI), were added. The main CHS clinic exams ended in June 1999. An additional examination was conducted in 2005 and an in-home visit is currently in progress. Since June 1999, two phone calls per year to participants have identified events and collected limited information, including hospitalizations and information about cardiovascular events. In 2005, when the NHLBI ceased funding for events data collection and adjudication, an investigator-initiated grant (HL080295, converted to a cooperative agreement) supported these activities until 2015. In 2015, when the NHLBI ceased funding infrastructure for CHS, an investigator-initiated grant (HL130114, converted to a cooperative agreement) continued support for the contact with participants and for the support of working groups. This proposal is written in response to the NHLBI RFP No.75N92018R0090 “Cardiovascular Health Study (CHS)” which seeks to move the CHS infrastructure from a cooperative agreement and the CHS Biospecimen Repository (N01HL268201800001C) to a single contract. In addition to study close out, the two scientific objectives are: 1) to maintain CHS as a research resource for the cardiovascular health of older adults; and 2) to deploy innovative approaches to assure the productive use of this infrastructure.