CARDIOVASCULAR HEALTH STUDY (CHS)- CORE STUDY OPERATIONS

心血管健康研究 (CHS) - 核心研究操作

• 批准号: 10788181
• 负责人: BRUCE PSATY
• 金额: $ 339.78万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-11-01 至 2023-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10788181
• 关键词: Address; African American; Ancillary Study; Applications Grants; Biological Specimen Banks; Budgets; Cardiovascular system; Cephalic; Clinic; Cohort Studies; Contracts; Coronary heart disease; Data; Data Analyses; Data Collection; Databases; Development; Echocardiography; Elderly; Event; Funding; Grant; Heart Diseases; Home visitation; Hospitalization; Infrastructure; Magnetic Resonance Imaging; Mentors; Methods; National Heart, Lung, and Blood Institute; Outcome; Participant; Population Heterogeneity; Process; Productivity; Questionnaires; Research Personnel; Resources; Risk Factors; Sampling; Specimen; Stroke; Telephone; U-Series Cooperative Agreements; Woman; Writing; adjudication; aged; biobank; cardiovascular health; cohort; data management; follow-up; innovation; men; mortality; operation; population based; prospective; pulmonary function; recruit; response; ultrasound; working group

The Cardiovascular Health Study (CHS) is a cohort study of risk factors for coronary heart disease and stroke in a diverse population-based sample of men and women aged 65 years or older at baseline. The main objective is to identify factors related to the onset and course of heart disease and stroke. The original cohort of 5201 elderly were recruited in 1989-1990; and in 1992-1993, 687 additional African American participants were recruited and examined. At baseline, participants answered questionnaires and were examined, including carotid ultrasound, echocardiography, and pulmonary function. During follow-up, 1990-1999, many baseline examination components were repeated, and a few new ones, including cranial magnetic resonance imaging (MRI), were added. The main CHS clinic exams ended in June 1999. An additional examination was conducted in 2005 and an in-home visit is currently in progress. Since June 1999, two phone calls per year to participants have identified events and collected limited information, including hospitalizations and information about cardiovascular events. In 2005, when the NHLBI ceased funding for events data collection and adjudication, an investigator-initiated grant (HL080295, converted to a cooperative agreement) supported these activities until 2015. In 2015, when the NHLBI ceased funding infrastructure for CHS, an investigator-initiated grant (HL130114, converted to a cooperative agreement) continued support for the contact with participants and for the support of working groups. This proposal is written in response to the NHLBI RFP No.75N92018R0090 “Cardiovascular Health Study (CHS)” which seeks to move the CHS infrastructure from a cooperative agreement and the CHS Biospecimen Repository (N01HL268201800001C) to a single contract. In addition to study close out, the two scientific objectives are: 1) to maintain CHS as a research resource for the cardiovascular health of older adults; and 2) to deploy innovative approaches to assure the productive use of this infrastructure.

心血管健康研究（CHS）是一项在基线时年龄≥ 65岁的男性和女性的多样化人群样本中进行的冠心病和卒中风险因素队列研究。主要目的是确定与心脏病和中风的发病和病程相关的因素。最初的队列5201老年人在1989年至1990年招募，并在1992年至1993年，687个额外的非洲裔美国人参与者被招募和检查。在基线时，参与者回答问卷并进行检查，包括颈动脉超声，超声心动图和肺功能。在1990-1999年的随访中，重复了许多基线检查，并增加了一些新的检查，包括颅骨检查。 磁共振成像（MRI）。主要的社区卫生服务诊所考试于1999年6月结束。2005年又进行了一次检查，目前正在进行家访。自1999年6月以来，每年给参与者打两次电话，以确定事件并收集有限的信息，包括住院和有关心血管事件的信息。2005年，当NHLBI停止资助事件数据收集和裁定时，一项由仲裁员发起的赠款（HL 080295，转换为合作协议）支持这些活动，直到2015年。2015年，当NHLBI停止资助CHS的基础设施时，一项由赞助商发起的赠款（HL 130114，转换为合作协议）继续支持与参与者的联系和对工作组的支持。本提案是针对NHLBI RFP No.75N92018R0090“心血管健康”编写的 研究（CHS）”，旨在将CHS基础设施从合作协议和CHS生物标本储存库（N 01 HL 268201800001 C）转移到单一合同。除了研究结束外，两个科学目标是：1）保持CHS作为老年人心血管健康的研究资源; 2）部署创新方法，以确保该基础设施的有效利用。