Extending Sleep in Obese Adults to Promote Weight Loss

延长肥胖成年人的睡眠以促进减肥

基本信息

  • 批准号:
    7589165
  • 负责人:
  • 金额:
    $ 24.47万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-04-01 至 2011-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by investigator): Approximately two-thirds of all adults in the United States are estimated to be overweight or obese. No demographic group has been spared; increased rates of obesity have been documented in all age groups, in both sexes, and among all ethnic groups. Explanations for the dramatic increase in obesity include increasingly sedentary lifestyles, and changes in food manufacturing and marketing practices, the increased use of central heating and air conditioning, increasing gravid age, decreased smoking rates, and decreased sleep durations. Sleep loss due to voluntary curtailment of sleep is common among Americans of all ages. Numerous epidemiologic studies have revealed a dose-dependant relationship between reduced sleep duration and increased body mass index (BMI). In addition, well-controlled laboratory studies have documented that sleep loss appears to up-regulate appetite by altering the ability of metabolic hormones to accurately signal caloric need, alters glucose metabolism and increases insulin resistance, and elevates blood pressure. It has been suggested--but never tested--that extending sleep will facilitate weight loss. Therefore, the goal is of this project is to lay the groundwork for a future clinical trial testing the hypothesis that healthy obese individuals who obtain at least 7.5 hours sleep per night will loose more weight than healthy obese adults obtaining 6.5 hours sleep per night. Specifically, the goals of this project include: 1) feasibility testing of a sleep extension protocol as an adjuvant to traditional weight loss programs; 2) comparing the efficacy of sleep extension in combination with caloric restriction and exercise to a traditional weight control program consisting of caloric restriction and exercise for facilitating weight loss in obese individuals; 3) comparing the efficacy of a sleep extension protocol in combination with caloric restriction and exercise to a traditional weight loss program consisting of caloric restriction and exercise to a traditional weight loss program consisting of caloric restriction and exercise for normalizing glucose levels and blood pressure in healthy obese individuals; and 4) explore the effect of sleep extension on leptin and ghrelin levels. The sleep extension protocol will utilize the same principles as the behavioral modification protocol already in use at Temple University's Center for Obesity Research and Education e.g., making incremental but sustainable changes in behavior, setting weekly behavioral goals, self-monitoring of progress towards goals, identification of barriers, etc., and will be incorporated into weekly group meetings. PUBLIC HEALTH RELEVANCE: Approximately two-thirds of all adults in the United States are estimated to be overweight or obese. Since even moderate amounts of excess weight are associated with increased morbidity and mortality, additional strategies are needed to combat the growing obesity epidemic. This study represents a beginning step in determining if extending sleep would assist individuals in loosing weight.
描述(由调查人员提供):据估计,美国大约三分之二的成年人超重或肥胖。没有一个人口群体幸免于难;所有年龄段、性别和所有种族群体的肥胖率都有所增加。肥胖症急剧增加的原因包括越来越多的久坐不动的生活方式,以及食品生产和营销实践的变化,中央供暖和空调的使用增加,怀孕年龄增加,吸烟率下降,睡眠时间缩短。由于自愿减少睡眠而导致的睡眠不足在所有年龄段的美国人中都很常见。许多流行病学研究表明,睡眠时间减少和体重指数(BMI)增加之间存在剂量依赖关系。此外,控制良好的实验室研究证明,睡眠不足似乎通过改变代谢荷尔蒙准确发出热量需求信号的能力来上调食欲,改变葡萄糖代谢,增加胰岛素抵抗,并升高血压。有人建议--但从未被证实--延长睡眠时间将有助于减肥。因此,该项目的目标是为未来的临床试验奠定基础,以检验这一假设,即每晚睡眠至少7.5小时的健康肥胖者比每晚睡6.5小时的健康肥胖者减轻的体重更多。具体地说,该项目的目标包括:1)测试作为传统减肥计划辅助的延长睡眠方案的可行性;2)比较睡眠延长结合卡路里限制和锻炼与传统体重控制计划的效果,其中传统体重控制计划包括热量限制和运动,以促进肥胖者的减肥;3)比较睡眠延长方案与传统减肥计划的效果,其中传统减肥计划包括热量限制和锻炼,以使健康肥胖者的血糖水平和血压正常化;以及4)探索延长睡眠时间对瘦素和胃促生长素水平的影响。睡眠延长协议将利用与坦普尔大学肥胖研究和教育中心已经使用的行为修改协议相同的原则,例如,对行为进行渐进但可持续的改变,设定每周的行为目标,自我监控实现目标的进展,识别障碍等,并将被纳入每周的小组会议。与公共健康相关:据估计,美国约三分之二的成年人超重或肥胖。由于即使是适度的超重也会增加发病率和死亡率,因此需要采取更多的战略来抗击日益严重的肥胖症流行。这项研究是确定延长睡眠是否有助于减肥的第一步。

项目成果

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ANN E ROGERS其他文献

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{{ truncateString('ANN E ROGERS', 18)}}的其他基金

Extending Sleep in Obese Adults to Promote Weight Loss
延长肥胖成年人的睡眠以促进减肥
  • 批准号:
    8133228
  • 财政年份:
    2009
  • 资助金额:
    $ 24.47万
  • 项目类别:
Graduate Education in Occupational Environmental Health
职业环境卫生研究生教育
  • 批准号:
    7619551
  • 财政年份:
    2005
  • 资助金额:
    $ 24.47万
  • 项目类别:
Staff Nurse Fatigue and Patient Safety
护士疲劳与患者安全
  • 批准号:
    6804163
  • 财政年份:
    2001
  • 资助金额:
    $ 24.47万
  • 项目类别:
Staff Nurse Fatigue and Patient Safety
护士疲劳与患者安全
  • 批准号:
    6661069
  • 财政年份:
    2001
  • 资助金额:
    $ 24.47万
  • 项目类别:
Staff Nurse Fatigue and Patient Safety
护士疲劳与患者安全
  • 批准号:
    6455646
  • 财政年份:
    2001
  • 资助金额:
    $ 24.47万
  • 项目类别:
Staff Nurse Fatigue and Patient Safety
护士疲劳与患者安全
  • 批准号:
    6591630
  • 财政年份:
    2001
  • 资助金额:
    $ 24.47万
  • 项目类别:
Staff Nurse Fatigue and Patient Safety
护士疲劳与患者安全
  • 批准号:
    6528365
  • 财政年份:
    2001
  • 资助金额:
    $ 24.47万
  • 项目类别:
Staff Nurse Fatigue and Patient Safety
护士疲劳与患者安全
  • 批准号:
    6664978
  • 财政年份:
    2001
  • 资助金额:
    $ 24.47万
  • 项目类别:
MANAGEMENT OF EXCESSIVE DAYTIME SLEEPINESS IN NARCOLEPSY
发作性睡病患者白天过度嗜睡的治疗
  • 批准号:
    6351758
  • 财政年份:
    1997
  • 资助金额:
    $ 24.47万
  • 项目类别:
MANAGEMENT OF EXCESSIVE DAYTIME SLEEPINESS IN NARCOLEPSY
发作性睡病患者白天过度嗜睡的治疗
  • 批准号:
    2655412
  • 财政年份:
    1997
  • 资助金额:
    $ 24.47万
  • 项目类别:

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