Mentored research in the intersection of kidney and cardiovascular disease

肾脏和心血管疾病交叉领域的指导研究

• 批准号: 10795588
• 负责人: Nisha Bansal
• 金额: $ 10.97万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-06 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10795588
• 关键词: Academia; Acute Renal Failure with Renal Papillary Necrosis; Address; Administrative Supplement; Alaska; American Indians; Arrhythmia; Asian Americans; Award; Awareness; Cardiovascular Diseases; Chronic Kidney Failure; Clinical; Clinical Trials; Coupled; Development; Diagnosis; Dialysis procedure; Disease; Disparity; Education; Educational Status; Endowment; Ethnic Origin; Family; Fellowship; Foundations; Functional disorder; Funding; Future; Gender; Geography; Grant; Growth; Heart failure; Idaho; Individual; Journals; Kidney Diseases; Kidney Failure; Kidney Transplantation; Leadership; Lesbian Gay Bisexual Transgender Queer; Measures; Medicine; Mentors; Mentorship; Mission; Montana; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; Pacific Islander; Patients; Persons; Philosophy; Physicians; Postdoctoral Fellow; Productivity; Publications; Publishing; Race; Research; Research Infrastructure; Research Support; Resources; Scholarship; Science; Scientist; Socioeconomic Status; Source; Students; Talents; Time; Training; Underrepresented Populations; United States National Institutes of Health; Universities; Washington; Woman; Work; Wyoming; career; doctoral student; education research; epidemiology study; health equity; hypertension treatment; interest; next generation; outreach program; patient oriented research; post-doctoral training; professor; programs; racial diversity; racism; risk stratification; rural area; sex; success; training opportunity

ABSTRACT I am a mid-career nephrologist, a newly promoted Professor, the holder of Arthur Stach Endowed Professorship and the Director of Nephrology Clinical and Research Education in the Division of Nephrology at the University of Washington (UW). I have been a NIDDK-funded physician-scientist since the completion of my fellowship in 2010; and have an active patient-oriented research program that focuses on the intersection of kidney and cardiovascular disease. My work encompasses epidemiological studies, mechanistic studies, and clinical trials all focused on the pathophysiology, diagnosis, risk stratification and treatment of hypertension, heart failure and cardiac arrhythmias in patients with chronic kidney disease, acute kidney injury and kidney failure (treated with dialysis or kidney transplant). I am currently the PI of three NIH R01s, the co- Director of the UW Nephrology NIDDK T32, co-I on two NIH U01s and the PI of two NIH administrative supplements. One of the greatest joys and privileges of my career to date has been the opportunity to serve as mentor. My success as a mentor is measured by my mentee’s success. My current and previous grants have provided numerous rich opportunities for training for post-doctoral students, residents and fellows. I have been a mentor for 24 talented individuals since 2010, including 63% women, 50% Asian American persons, 30% persons underrepresented in medicine or science by race, ethnicity, gender identify and family educational status. Of these, 63% of my mentees remain in academia and continue in scholarship or research. The work of these mentees has been productive, yielding >40 first author publications and ten NIH or foundation grants. There is a critical need to increase mentorship for individuals from diverse backgrounds. It is well known that advances in NIDDK-focused diseases are in crisis as fewer physician and scientists choose to pursue research careers. In particular, diverse research teams are needed to address racism and disparities in medicine and science. Mentorship is a critical factor cited by students for inspiring their interest in scientific careers. Locally, the UW, located in Seattle, WA, is unique in its mission to attract trainees from across a five-state region of Washington, Wyoming, Alaska, Montana and Idaho, who are diverse by race (including American Indian and Pacific Islander), ethnicity, sex, gender, geography (many from rural areas), ability, LGBTQ+ and socioeconomic status. Coupled with established outreach programs at UW and the sizable pool of post- doctoral trainees from these diverse backgrounds, there is tremendous opportunity to cultivate the next generation of NIDDK diverse scientists in this region. I am committed to mentoring persons from backgrounds underrepresented in medicine and science to increase the diversity of the future NIDDK biomedical scientific workforce. This award will provide key resources, training and professional development that will enhance my ability to serve as an effective mentor for post-doctoral trainees from diverse backgrounds.

摘要 我是一个职业生涯中期的肾病学家，一个新晋升的教授，亚瑟斯塔赫捐赠的保持器持有者 教授和肾脏病学临床和研究教育主任，在肾脏病学部， 华盛顿大学（UW）。我一直是一个NIDDK资助的医生，科学家，因为完成 我的奖学金在2010年;并有一个积极的以病人为导向的研究计划，重点是交叉 肾脏和心血管疾病。我的工作包括流行病学研究，机理研究， 和临床试验都集中在病理生理学，诊断，风险分层和治疗， 慢性肾脏病、急性肾损伤患者的高血压、心力衰竭和心律失常 和肾衰竭（通过透析或肾移植治疗）。我目前是三个NIH R 01的PI，共同- UW肾病NIDDK T32主任，两个NIH U 01的共同I和两个NIH行政PI 补充剂.迄今为止，我职业生涯中最大的乐趣和特权之一就是有机会担任 导师我作为导师的成功是由我的学员的成功来衡量的。 我目前和以前的赠款提供了许多丰富的机会，培养博士后 学生、住院医生和研究员。自2010年以来，我已经成为24位有才华的人的导师，其中63% 女性，50%亚裔美国人，30%按种族分列的医学或科学领域代表性不足的人， 民族、性别认同和家庭教育状况。其中，63%的学员留在学术界， 继续从事学术或研究。这些学员的工作是富有成效的，产生了>40第一作者 出版物和10个NIH或基金会赠款。 迫切需要加强对不同背景的个人的指导。众所周知的是 随着越来越少的医生和科学家选择从事研究，以NIDDK为重点的疾病的进展正处于危机之中 careers.特别是，需要多样化的研究团队来解决种族主义和医学方面的差异， 科学导师制是激发学生对科学事业兴趣的一个关键因素。在当地， 华盛顿大学位于华盛顿州的西雅图，其独特的使命是吸引来自五个州的受训人员， 华盛顿、怀俄明州、阿拉斯加、蒙大拿州和爱达荷州，这些地区种族多样（包括美洲印第安人和 太平洋岛民），种族，性别，性别，地理（许多来自农村地区），能力，LGBTQ+和 社会经济地位。再加上在华盛顿大学建立的外展计划和相当大的后池， 来自这些不同背景的博士生，有巨大的机会培养下一个 NIDDK的一代不同的科学家在这个地区。我致力于指导来自不同背景的人， 在医学和科学中代表性不足，以增加未来NIDDK生物医学科学的多样性 劳动力该奖项将提供关键的资源，培训和专业发展，将提高我的 有能力为来自不同背景的博士后学员担任有效的导师。