Mentored research in the intersection of kidney and cardiovascular disease

肾脏和心血管疾病交叉领域的指导研究

• 批准号: 10795588
• 负责人: Nisha Bansal
• 金额: $ 10.97万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-06 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10795588
• 关键词: Academia; Acute Renal Failure with Renal Papillary Necrosis; Address; Administrative Supplement; Alaska; American Indians; Arrhythmia; Asian Americans; Award; Awareness; Cardiovascular Diseases; Chronic Kidney Failure; Clinical; Clinical Trials; Coupled; Development; Diagnosis; Dialysis procedure; Disease; Disparity; Education; Educational Status; Endowment; Ethnic Origin; Family; Fellowship; Foundations; Functional disorder; Funding; Future; Gender; Geography; Grant; Growth; Heart failure; Idaho; Individual; Journals; Kidney Diseases; Kidney Failure; Kidney Transplantation; Leadership; Lesbian Gay Bisexual Transgender Queer; Measures; Medicine; Mentors; Mentorship; Mission; Montana; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; Pacific Islander; Patients; Persons; Philosophy; Physicians; Postdoctoral Fellow; Productivity; Publications; Publishing; Race; Research; Research Infrastructure; Research Support; Resources; Scholarship; Science; Scientist; Socioeconomic Status; Source; Students; Talents; Time; Training; Underrepresented Populations; United States National Institutes of Health; Universities; Washington; Woman; Work; Wyoming; career; doctoral student; education research; epidemiology study; health equity; hypertension treatment; interest; next generation; outreach program; patient oriented research; post-doctoral training; professor; programs; racial diversity; racism; risk stratification; rural area; sex; success; training opportunity

ABSTRACT I am a mid-career nephrologist, a newly promoted Professor, the holder of Arthur Stach Endowed Professorship and the Director of Nephrology Clinical and Research Education in the Division of Nephrology at the University of Washington (UW). I have been a NIDDK-funded physician-scientist since the completion of my fellowship in 2010; and have an active patient-oriented research program that focuses on the intersection of kidney and cardiovascular disease. My work encompasses epidemiological studies, mechanistic studies, and clinical trials all focused on the pathophysiology, diagnosis, risk stratification and treatment of hypertension, heart failure and cardiac arrhythmias in patients with chronic kidney disease, acute kidney injury and kidney failure (treated with dialysis or kidney transplant). I am currently the PI of three NIH R01s, the co- Director of the UW Nephrology NIDDK T32, co-I on two NIH U01s and the PI of two NIH administrative supplements. One of the greatest joys and privileges of my career to date has been the opportunity to serve as mentor. My success as a mentor is measured by my mentee’s success. My current and previous grants have provided numerous rich opportunities for training for post-doctoral students, residents and fellows. I have been a mentor for 24 talented individuals since 2010, including 63% women, 50% Asian American persons, 30% persons underrepresented in medicine or science by race, ethnicity, gender identify and family educational status. Of these, 63% of my mentees remain in academia and continue in scholarship or research. The work of these mentees has been productive, yielding >40 first author publications and ten NIH or foundation grants. There is a critical need to increase mentorship for individuals from diverse backgrounds. It is well known that advances in NIDDK-focused diseases are in crisis as fewer physician and scientists choose to pursue research careers. In particular, diverse research teams are needed to address racism and disparities in medicine and science. Mentorship is a critical factor cited by students for inspiring their interest in scientific careers. Locally, the UW, located in Seattle, WA, is unique in its mission to attract trainees from across a five-state region of Washington, Wyoming, Alaska, Montana and Idaho, who are diverse by race (including American Indian and Pacific Islander), ethnicity, sex, gender, geography (many from rural areas), ability, LGBTQ+ and socioeconomic status. Coupled with established outreach programs at UW and the sizable pool of post- doctoral trainees from these diverse backgrounds, there is tremendous opportunity to cultivate the next generation of NIDDK diverse scientists in this region. I am committed to mentoring persons from backgrounds underrepresented in medicine and science to increase the diversity of the future NIDDK biomedical scientific workforce. This award will provide key resources, training and professional development that will enhance my ability to serve as an effective mentor for post-doctoral trainees from diverse backgrounds.

抽象的 我是一名职业生涯中期的肾病专家，新晋升的教授，Arthur Stach Endowed 的持有者 肾脏病科教授兼肾脏病临床和研究教育主任 华盛顿大学（UW）。自完成 NIDDK 资助以来，我一直是一名 NIDDK 资助的医师科学家 我2010年的奖学金；并拥有一个积极的以患者为中心的研究计划，重点关注交叉点 肾脏和心血管疾病。我的工作包括流行病学研究、机制研究、 和临床试验均侧重于病理生理学、诊断、风险分层和治疗 慢性肾病、急性肾损伤患者的高血压、心力衰竭和心律失常 和肾衰竭（通过透析或肾移植治疗）。我目前是三个 NIH R01 的 PI， 华盛顿大学肾病科 NIDDK T32 主任、两个 NIH U01 的联合研究员和两个 NIH 行政部门的 PI 补充品。迄今为止，我职业生涯中最大的快乐和特权之一就是有机会担任 导师。我作为导师的成功是通过我的受训者的成功来衡量的。 我当前和之前的资助为博士后培训提供了许多丰富的机会 学生、居民和研究员。自 2010 年以来，我一直是 24 名才华横溢的人的导师，其中 63% 女性、50% 亚裔美国人、30% 因种族原因在医学或科学领域代表性不足的人， 种族、性别认同和家庭教育状况。其中，我的学员中有 63% 仍留在学术界 继续从事学术或研究。这些受训者的工作卓有成效，产生了超过 40 位第一作者 出版物和十项 NIH 或基金会拨款。 迫切需要加强对来自不同背景的个人的指导。众所周知， 由于越来越少的医生和科学家选择进行研究，以 NIDDK 为重点的疾病的进展陷入危机 职业生涯。特别是，需要多元化的研究团队来解决种族主义和医学领域的差异 科学。指导是学生们认为激发他们对科学职业兴趣的一个关键因素。在当地， 华盛顿大学位于华盛顿州西雅图，其独特的使命是吸引来自美国五个州地区的学员 华盛顿州、怀俄明州、阿拉斯加、蒙大拿州和爱达荷州，这些州的种族多种多样（包括美洲印第安人和 太平洋岛民）、种族、性别、性别、地理位置（许多来自农村地区）、能力、LGBTQ+ 和 社会经济地位。再加上威斯康星大学既定的外展计划和大量的后 来自这些不同背景的博士生，有巨大的机会培养下一代 该地区产生了一代 NIDDK 多元化的科学家。我致力于指导有背景的人 医学和科学领域代表性不足，以增加未来 NIDDK 生物医学科学的多样性 劳动力。该奖项将提供关键资源、培训和专业发展，从而增强我的能力 能够为来自不同背景的博士后学员提供有效的导师。