Facility Management, Maintenance and Operation Core

设施管理、维护和运营核心

• 批准号: 10793908
• 负责人: Raymond Paul Goodrich
• 金额: $ 133.84万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793908
• 关键词: 2019-nCoV; Academia; Address; Administrative Supplement; Advocate; Aging; Animal Husbandry; Award; Basic Science; Biological; Biological Sciences; Burkholderia pseudomallei; Calibration; Capital; Career Choice; Categories; Certification; Client; Collaborations; Colorado; Communicable Diseases; Communication; Conflict (Psychology); Cyclic GMP; Data; Dedications; Discipline; Disease; Eastern Equine Encephalitis Virus; Economic Burden; Education; Emerging Communicable Diseases; Ensure; Entrepreneurship; Environment; Equipment; Evaluation; Fees; Foundations; Francisella tularensis; Funding; Genus Mycobacterium; Goals; Good Manufacturing Process; Government Agencies; Grant; Hazardous Chemicals; Hazardous Substances; Human Resources; Industry; Infectious Diseases Research; Information Systems; Information Technology; Infrastructure; Institution; Investments; Laboratories; Leadership; Leprosy; Maintenance; Melioidosis; Middle East Respiratory Syndrome Coronavirus; Mission; Modernization; Monkeypox; National Institute of Allergy and Infectious Disease; Operations Research; Parents; Pharmacologic Substance; Plague; Process; Public Health; Research; Research Personnel; Research Support; Resolution; Resource Allocation; Resource Development; Resources; Risk; Science; Services; Site; Structure; System; Training; Translational Research; Tuberculosis; Tularemia; Universities; Update; Venezuelan Equine Encephalomyelitis; Vertebral column; Veterinary Medicine; Vision; Work; Workforce Development; aged; biodefense; biosafety level 3 facility; biosecurity; college; cost; design; emerging pathogen; faculty research; health economics; improved; instrument; laboratory facility; manufacture; non-tuberculosis mycobacteria; operation; pandemic disease; pandemic potential; pathogen; pathogenic bacteria; professional atmosphere; programs; repaired; response; socioeconomics; usability; viral pandemic; visiting scholar

Project Summary: The BSL3 suites in the Rocky Mountain Regional Biocontainment Laboratory (RMRBL) at Colorado State University (CSU) have been operational and at capacity since being commissioned. These facilities support research in response to new threats from established pathogens, such as Mycobacterium spp. (tuberculosis, leprosy, and emerging diseases caused by non-tuberculosis mycobacteria) and high consequence, select agent pathogens, such as Eastern Equine Encephalitis Virus, Venezuelan Equine Encephalitis, Francisella tularensis, and Burkholderia pseudomallei. The RMRBL BSL3 is required to pivot and rapidly respond to new, emerging pathogens with pandemic potential. The RMRBL has been exemplary, researching new threats such as MERS-CoV, MPox, and SARS-CoV-2. The RMRBL BSL3 thus represents the backbone of research capabilities in infectious disease at CSU. CSU, in turn has supported the facility for the past 15 years. CSU’s support includes much of the day-to-day operating costs of the RMRBL BSL3 facilities; remaining costs are covered by assessing user fees to CSU researchers based on square footage and entries. Expenses beyond day-to-day operational costs, including non-annual facilities repairs and replacement upgrades require additional advocating and are addressed when eminently needed. This disrupts crucial operations. Work within the BSL3 comes with a sacrifice to personal comfort due to the requirements for biosafety and biosecurity, along with the inherent risk of work on high consequence pathogens. Maintaining safe, operational and appropriate scientific instruments is challenged as servicing these instruments is difficult and frequently results in the need to replace equipment. The consequence of the cost, work environment, deprecating equipment and operational disruptions is our inability to maintain a trained workforce and sufficiently technically equipped BSL3 ‘warm ready’ space. In response to this challenge, we propose our Core 1 – Facility Management, Maintenance & Operations. This core is strategically designed to resolve many of the RMRBL BSL3 challenges through three functional aims; Aim 1 - Management, will improve upon the current structure for communication across research and support teams; Aim 2 – Maintenance, will maintain the RMRBL BSL3 facilities functionality through proactive preventative maintenance, reducing unplanned disruptions; and finally, Aim 3 – Operations, will institute dedicated operational and animal husbandry support and improve IT-communications within the RMRBL BSL3/ABSL3. Our comprehensive approach to improving the management, maintenance, and operations of the RMRBL BSL3 will result in an improved RMRBL BSL3 system that exemplifies communication and collaboration across our diverse leadership and research teams in a biosafe and bio-secure compliant environment. As a result, the penultimate goal of this core - to perpetuate warm ready RMRBL BSL3 facilities; compliant with the dynamic requirements for biosafety and biosecurity, appropriately resourced, and responsive to our national and state RBL mission – will be achieved.

项目摘要：位于落基山地区生物防护实验室 (RMRBL) 的 BSL3 套件 科罗拉多州立大学 (CSU) 自委托以来一直在运营并满负荷运转。这些 设施支持研究以应对现有病原体（例如分枝杆菌）的新威胁 种。 （结核病、麻风病和非结核分枝杆菌引起的新发疾病）和高 结果，选择病原体，例如东方马脑炎病毒、委内瑞拉马病毒 脑炎、土拉弗朗西斯菌和类鼻疽伯克霍尔德菌。 RMRBL BSL3 需要旋转和 快速应对具有大流行潜力的新出现的病原体。 RMRBL 堪称典范， 研究新的威胁，例如 MERS-CoV、MPox 和 SARS-CoV-2。因此，RMRBL BSL3 代表 科罗拉多州立大学传染病研究能力的骨干。科罗拉多州立大学反过来也支持该设施 过去15年。科罗拉多州立大学的支持包括 RMRBL BSL3 设施的大部分日常运营成本； 剩余费用通过根据面积和条目评估科罗拉多州立大学研究人员的使用费来支付。 日常运营成本之外的费用，包括非年度设施维修和更换 升级需要额外的倡导，并在迫切需要时得到解决。这扰乱了关键的 运营。由于要求，在 BSL3 内工作会牺牲个人舒适度 生物安全和生物安保，以及高后果病原体工作的固有风险。维护 由于维护这些仪器很困难，安全、可操作和适当的科学仪器受到挑战 并经常导致需要更换设备。成本、工作环境、 弃用设备和运营中断是我们无法维持训练有素的员工队伍和 技术装备齐全的 BSL3“温暖就绪”空间。为了应对这一挑战，我们提出了我们的核心 1 – 设施管理、维护和运营。该核心的战略设计旨在解决许多问题 RMRBL BSL3 通过三个功能目标提出挑战；目标 1 - 管理将改进当前 研究和支持团队之间的沟通结构；目标 2 – 维护，将维持 RMRBL BSL3 通过主动预防性维护实现设施功能，减少计划外 干扰；最后，目标 3 – 运营，将建立专门的运营和畜牧业支持 并改善 RMRBL BSL3/ABSL3 内的 IT 通信。我们的综合改进方法 RMRBL BSL3 的管理、维护和运营将导致 RMRBL BSL3 的改进 该系统体现了我们多元化领导和研究团队之间的沟通和协作 生物安全和生物安全合规环境。因此，该核心的倒数第二个目标是永存 热备 RMRBL BSL3 设施；符合生物安全和生物保安的动态要求， 适当的资源，并响应我们的国家和州 RBL 使命 - 将会实现。