Facility Management, Maintenance and Operation Core

设施管理、维护和运营核心

基本信息

  • 批准号:
    10793908
  • 负责人:
  • 金额:
    $ 133.84万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-08-18 至 2028-07-31
  • 项目状态:
    未结题

项目摘要

Project Summary: The BSL3 suites in the Rocky Mountain Regional Biocontainment Laboratory (RMRBL) at Colorado State University (CSU) have been operational and at capacity since being commissioned. These facilities support research in response to new threats from established pathogens, such as Mycobacterium spp. (tuberculosis, leprosy, and emerging diseases caused by non-tuberculosis mycobacteria) and high consequence, select agent pathogens, such as Eastern Equine Encephalitis Virus, Venezuelan Equine Encephalitis, Francisella tularensis, and Burkholderia pseudomallei. The RMRBL BSL3 is required to pivot and rapidly respond to new, emerging pathogens with pandemic potential. The RMRBL has been exemplary, researching new threats such as MERS-CoV, MPox, and SARS-CoV-2. The RMRBL BSL3 thus represents the backbone of research capabilities in infectious disease at CSU. CSU, in turn has supported the facility for the past 15 years. CSU’s support includes much of the day-to-day operating costs of the RMRBL BSL3 facilities; remaining costs are covered by assessing user fees to CSU researchers based on square footage and entries. Expenses beyond day-to-day operational costs, including non-annual facilities repairs and replacement upgrades require additional advocating and are addressed when eminently needed. This disrupts crucial operations. Work within the BSL3 comes with a sacrifice to personal comfort due to the requirements for biosafety and biosecurity, along with the inherent risk of work on high consequence pathogens. Maintaining safe, operational and appropriate scientific instruments is challenged as servicing these instruments is difficult and frequently results in the need to replace equipment. The consequence of the cost, work environment, deprecating equipment and operational disruptions is our inability to maintain a trained workforce and sufficiently technically equipped BSL3 ‘warm ready’ space. In response to this challenge, we propose our Core 1 – Facility Management, Maintenance & Operations. This core is strategically designed to resolve many of the RMRBL BSL3 challenges through three functional aims; Aim 1 - Management, will improve upon the current structure for communication across research and support teams; Aim 2 – Maintenance, will maintain the RMRBL BSL3 facilities functionality through proactive preventative maintenance, reducing unplanned disruptions; and finally, Aim 3 – Operations, will institute dedicated operational and animal husbandry support and improve IT-communications within the RMRBL BSL3/ABSL3. Our comprehensive approach to improving the management, maintenance, and operations of the RMRBL BSL3 will result in an improved RMRBL BSL3 system that exemplifies communication and collaboration across our diverse leadership and research teams in a biosafe and bio-secure compliant environment. As a result, the penultimate goal of this core - to perpetuate warm ready RMRBL BSL3 facilities; compliant with the dynamic requirements for biosafety and biosecurity, appropriately resourced, and responsive to our national and state RBL mission – will be achieved.
项目概要:落基山区域生物防护实验室(RMRBL)的BSL 3套房, 科罗拉多州立大学(CSU)自投入使用以来一直在运作。这些 设施支持研究,以应对来自已知病原体(如分枝杆菌)的新威胁 spp.(结核病、麻风病和由非结核分枝杆菌引起的新发疾病)和高 因此,选择代理病原体,如东部马脑炎病毒,委内瑞拉马脑炎病毒, Encephalitis,Francisella tularensis,和Burkholderia pseudomallei。RMRBL BSL 3需要旋转, 快速应对新出现的具有大流行潜力的病原体。皇家海军陆战队基地是一个典范, 研究MERS-CoV、MPox和SARS-CoV-2等新威胁。因此,RMRBL BSL 3表示 CSU传染病研究能力的骨干CSU反过来又支持了该设施, 过去15年CSU的支持包括RMRBL BSL 3设施的大部分日常运营费用; 其余的费用通过根据平方英尺和条目评估CSU研究人员的使用费来支付。 日常业务费用以外的支出,包括非年度设施维修和更换 升级需要更多的宣传,并在非常需要时加以解决。这破坏了 运营在BSL 3内工作会牺牲个人舒适度,因为要求 生物安全和生物安保,沿着高后果病原体工作的固有风险。保持 安全、可操作和适当的科学仪器受到挑战,因为维修这些仪器很困难 并且经常导致需要更换设备。成本,工作环境, 废弃设备和运营中断是我们无法维持训练有素的劳动力, 技术装备齐全的BSL 3“温暖就绪”空间。为了应对这一挑战,我们提出了核心 1 -设施管理、维护和运营。这一核心战略旨在解决许多 RMRBL BSL 3通过三个功能目标提出挑战;目标1 -管理,将改进当前的 研究和支持团队之间的通信结构;目标2 -维护,将维护 RMRBL BSL 3设施功能通过主动预防性维护, 最后,目标3 -运营,将建立专门的运营和畜牧业支持 并改善RMRBL BSL 3/ABSL 3内的IT通信。我们全面的方法来改善 对远程无线电基础设施BSL 3的管理、维护和操作将导致远程无线电基础设施BSL 3的改进 系统,加强我们不同的领导和研究团队之间的沟通和协作, 一个符合生物安全和生物安保的环境。因此,这一核心的倒数第二个目标-使 热就绪的RMRBL BSL 3设施;符合生物安全和生物安保的动态要求, 适当的资源,并响应我们的国家和国家的RBL使命-将实现。

项目成果

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