BSL-3 Practices Core

BSL-3 实践核心

• 批准号: 10793909
• 负责人: Rebecca Moritz
• 金额: $ 63.43万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793909
• 关键词: Animal Husbandry; Area; Awareness; Biometry; Bioterrorism; Charge; Colorado; Communities; Competence; Comprehension; Containment; County; Dedications; Educational Curriculum; Educational process of instructing; Educational workshop; Effectiveness; Elements; Emergency Situation; Emergency response; Ensure; Environment; Equipment and supply inventories; Evaluation; Evolution; Exercise; Feedback; Fostering; Funding; Goals; Human Resources; Information Technology; Infrastructure; Institution; Investigation; Laboratories; Laboratory Personnel; Laboratory Research; Maintenance; Mission; Modernization; Persons; Policies; Procedures; Process; Public Health; Reaction; Reader; Readiness; Research; Research Personnel; Resource Development; Resources; Safety; Secure; Security; Specialist; Standardization; System; Time; Training; Universities; Update; Work; Workforce Development; biosecurity; design; emergency preparedness; evidence base; experience; flexibility; improved; intrusion detection system; member; operation; prevent; programs; risk mitigation; synergism

Project Summary: The Rocky Mountain Regional Biocontainment Laboratory (RMRBL) must maintain excellence in biosafety and biosecurity to fulfill its charge of responding to public health and potential bioterrorism emergencies. Updating, modernizing, and continuously improving the biosafety and biosecurity program at the RMRBL ensures that researchers can effectively contribute to the important mission of the RBL network. This BSL-3 Practices Core will facilitate the long-term goals for sustaining high quality biosafety and biosecurity in the RMRBL through three overarching aims. Aim 1- Continuous evolution of biosafety and biosecurity for a dynamic research environment is critical for protecting researchers, the community, and the environment. Efforts supported by this funding will include modernizing current training using universal design principles and evidence-based teaching strategies for improved retention. New feedback mechanisms will be developed to promote regular updates to training based on ever-changing research needs. Emergency response and crisis management training will be amplified so personnel are better equipped to automatically react according to standard operating procedures. This includes coordinating with external emergency management partners for live scenarios and table-top exercises. Aim 2- Enhancing biosecurity through modernization of physical and administrative infrastructure will bring current RMRBL biosecurity systems up to date and provide a robust framework for a comprehensive biosecurity program. Keeping up with rapid changes in information technology and global interconnectedness is an increasing challenge. Through this project, the RMRBL biosecurity program will undergo physical security upgrades and administrative support expansion. Considering the increased public awareness of high containment laboratory research, proactive changes to the RMRBL biosecurity program will facilitate adaptation in the face of a changing regulatory environment. This is essential for constant readiness in line with the mission of the RBL network. Aim 3- Strengthening administrative controls for alignment with biosafety and biosecurity best practices will build safety culture among RMRBL personnel. In synergy with Aim 1, standard operating procedures (SOPs), plans, policies, practices, and inventory systems will be strategically reviewed and updated with an emphasis on researcher comprehension and ease of use. Developing consistent feedback mechanisms for users about the effectiveness of administrative controls will increase buy-in. New ideas for improving RMRBL processes will be gathered during personnel exchanges with other RBL network biosafety teams. Additionally, biosafety and biosecurity best practices will be reinforced through systematic investigation of the effectiveness of risk mitigation strategies. In sum, this core will ensure that biosafety and biosecurity at the RMRBL is contemporary and flexible to adequately support the mission of the RBL network.

项目摘要：落基山区域生物内在实验室（RMRBL）必须维持 卓越的生物安全和生物安全性，以履行其对公共卫生和潜力的回应的指控 生物恐怖主义紧急情况。更新，现代化并不断改善生物安全和 RMRBL的生物安全计划可确保研究人员可以有效地有助于重要 RBL网络的任务。这种BSL-3实践核心将促进维持的长期目标 RMRBL的高质量生物安全和生物安全通过三个总体目标。目标1-连续 生物安全和生物安全性在动态研究环境中的演变对于保护至关重要 研究人员，社区和环境。这笔资金支持的努力将包括 使用通用设计原理和基于证据的教学策略现代化当前培训 用于提高保留率。将开发新的反馈机制，以促进定期更新 基于不断变化的研究需求的培训。紧急响应和危机管理培训 将会放大 程序。这包括与外部紧急管理合作伙伴进行实时场景协调 和桌面练习。瞄准2-通过现代化物理和现代化增强生物安全性 行政基础设施将使当前的RMRBL生物安全系统保持最新状态并提供强大的 全面生物安全计划的框架。跟上信息快速变化 技术和全球相互联系是一个日益严重的挑战。通过这个项目，RMRBL 生物安全计划将进行物理安全升级和行政支持扩展。 考虑到公众对高遏制实验室研究的认识提高，积极的变化 面对RMRBL生物安全计划将有助于面对不断变化的监管 环境。这对于符合RBL网络的任务不断准备至关重要。瞄准3- 加强与生物安全和生物安全最佳实践保持一致的行政控制将建立 RMRBL人员的安全文化。与AIM 1协同作用，标准操作程序（SOP）， 计划，政策，实践和库存系统将进行战略性审查和更新 强调研究人员的理解和易用性。开发一致的反馈机制 对于用户，关于行政控制的有效性将增加买入。改进的新想法 RMRBL流程将在与其他RBL网络生物安全团队的人员交流期间收集。 此外，将通过系统调查来加强生物安全和生物安全性最佳实践 降低风险策略的有效性。总而言之，该核心将确保生物安全和生物安全性 在RMRBL处是现代且灵活的，可以充分支持RBL网络的任务。