Resources and workforce development for the New England Regional Biosafety Laboratory

新英格兰地区生物安全实验室的资源和劳动力发展

• 批准号: 10793931
• 负责人: Cheryl A London
• 金额: $ 243.51万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793931
• 关键词: Address; Animal Model; Animal Welfare; Bacteriology; Biological Models; Biology; Categories; Certification; Communicable Diseases; Communities; Community Health Education; Community Outreach; Competence; Complement; Containment; Decontamination; Disease; Eastern Equine Encephalomyelitis; Education; Elements; Emerging Communicable Diseases; Ensure; Environment; Environmental Health; Equipment; Future; Goals; Health; Human Resources; Individual; Industry; Infection; Infectious Diseases Research; Influenza; Infrastructure; Institution; Knowledge; Laboratories; Laboratory Animal Medicine; Laboratory Research; Maintenance; Methods; Microbiology; Mission; Mycobacterium tuberculosis; National Institute of Allergy and Infectious Disease; New England; Operations Research; Positioning Attribute; Postdoctoral Fellow; Powassan encephalitis; Preventive; Procedures; Protocols documentation; Qualifying; Research; Research Assistant; Research Personnel; Research Support; Resource Development; Resources; Risk; Safety; Schedule; Schools; Scientist; Services; Specialist; System; Technical Expertise; Training; Tularemia; United States National Institutes of Health; Universities; Work; Workforce Development; biocontainment facility; biosecurity; contextual factors; design; experience; industry partner; laboratory manuals; medical countermeasure; member; operation; pandemic disease; pandemic pathogen; pandemic potential; pandemic response; pathogen; professor; public health emergency; repaired; response; screening; skills; vector; virology

PROJECT SUMMARY - OVERALL The New England Regional Biosafety Laboratory (NERBL) was established in 2008 with the goal of ensuring that research and tasks in response to pathogens of pandemic potential and other emerging infections (PPP/EI) are safely, efficiently, and rigorously accomplished. The NERBL was also designed to serve as a regional resource for academic and industry partners engaged in activities that yield knowledge and medical countermeasures to PPP/EI and ready to serve as directed by NIH/NIAID/federal partners in whatever capacity necessary for pandemic response. A critical element necessary for effective functioning of any biosafety/biocontainment laboratory is the existence of core competencies associated with physical, operational, regulatory and research (vivarium/laboratory) tasks frequently performed in this setting. Individuals working in the context of biocontainment must possess advanced technical skills, have undergone extensive BSL-3/ABSL-3 training, and continuously enhance their knowledge regarding agent specific risk. Additionally, to maintain operational integrity of a biocontainment facility and adequately safeguard the staff, environment, and local community, functional redundancies in these skills and associated responsibilities are an absolute necessity. As such, the primary objective of this application is to expand and maintain a footprint of highly qualified staff within the NERBL that possess a set of core competencies for specific function categories (i.e., vivarium, facilities), while also cross-trained to undertake additional responsibilities should the need arise. Accordingly, we have proposed three Cores within the context of this application to achieve this overarching goal. Core 1 will oversee facility management, maintenance and operations, ensuring integrity and sustainability of the NERBL infrastructure. Core 2 will entail activities that cover BSL3/ABSL3 best practices, including laboratory specific biosafety, biosecurity education, vivarium specific trainings and research competencies. Lastly, Core 3 will serve as the biocontainment research support services core, expanding capacities for bacteriology, virology and vector biology. Core members will undergo rigorous cross-training to create the functional redundancies necessary for ensuring continuity of services. Together, these activities will allow us to fulfill our mission as a resource for Tufts University, academic partners, industry entities, state/federal investigators, as well as for our RBL/NBL Network members. Importantly, following completion of the stated milestones, the NERBL will be well-positioned and sufficiently resourced to rapidly respond to future emerging infectious disease threats.

项目摘要 - 总体 新英格兰地区生物安全实验室（NERBL）成立于2008年，目的是确保 这项研究和任务响应大流行潜力和其他新兴感染的病原体 （PPP/EI）安全，有效，严格地完成。 Nerbl也被设计为 为学术和行业合作伙伴提供的区域资源，从事能够产生知识和医学的活动 对PPP/EI的对策，并准备按照NIH/NIAID/联邦合作伙伴的指示服务 大流行反应所必需的。有效运行任何的关键要素 生物安全/生物内在实验室是与身体， 在这种情况下经常执行的操作，监管和研究（Vivarium/Laboratory）任务。 在生物内部维护背景下工作的个人必须具有高级技术技能，经历了 广泛的BSL-3/ABSL-3培训，并不断增强其有关特定风险的知识。 此外，要维持生物维护设施的运营完整性并充分保护工作人员， 环境和当地社区，这些技能和相关责任的功能裁员是 绝对必要。因此，本应用程序的主要目的是扩展和维护 Nerbl中高素质员工的足迹，该员工拥有一套核心竞争力 特定功能类别（即Vivarium，设施），同时也进行了交叉培训以进行其他 应有的责任应产生。因此，我们在此背景下提出了三个核心 实现这一总体目标的应用。核心1将监督设施管理，维护和 运营，确保Nerbl基础设施的完整性和可持续性。核心2将需要活动 涵盖BSL3/ABSL3最佳实践，包括实验室特定的生物安全，生物安全教育，Vivarium 特定的培训和研究能力。最后，核心3将作为生物内在研究 支持服务核心，扩大细菌学，病毒学和媒介生物学的能力。核心成员会 进行严格的交叉训练，以创建确保连续性所必需的功能冗余 服务。这些活动将使我们能够履行塔夫茨大学资源的使命， 学术合作伙伴，行业实体，州/联邦调查人员以及我们的RBL/NBL网络 成员。重要的是，在完成陈述的里程碑之后，nerbl的位置良好，并且 足够的资源可以迅速应对未来新兴的传染病威胁。