Resources and workforce development for the New England Regional Biosafety Laboratory

新英格兰地区生物安全实验室的资源和劳动力发展

• 批准号: 10793931
• 负责人: Cheryl A London
• 金额: $ 243.51万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793931
• 关键词: Address; Animal Model; Animal Welfare; Bacteriology; Biological Models; Biology; Categories; Certification; Communicable Diseases; Communities; Community Health Education; Community Outreach; Competence; Complement; Containment; Decontamination; Disease; Eastern Equine Encephalomyelitis; Education; Elements; Emerging Communicable Diseases; Ensure; Environment; Environmental Health; Equipment; Future; Goals; Health; Human Resources; Individual; Industry; Infection; Infectious Diseases Research; Influenza; Infrastructure; Institution; Knowledge; Laboratories; Laboratory Animal Medicine; Laboratory Research; Maintenance; Methods; Microbiology; Mission; Mycobacterium tuberculosis; National Institute of Allergy and Infectious Disease; New England; Operations Research; Positioning Attribute; Postdoctoral Fellow; Powassan encephalitis; Preventive; Procedures; Protocols documentation; Qualifying; Research; Research Assistant; Research Personnel; Research Support; Resource Development; Resources; Risk; Safety; Schedule; Schools; Scientist; Services; Specialist; System; Technical Expertise; Training; Tularemia; United States National Institutes of Health; Universities; Work; Workforce Development; biocontainment facility; biosecurity; contextual factors; design; experience; industry partner; laboratory manuals; medical countermeasure; member; operation; pandemic disease; pandemic pathogen; pandemic potential; pandemic response; pathogen; professor; public health emergency; repaired; response; screening; skills; vector; virology

PROJECT SUMMARY - OVERALL The New England Regional Biosafety Laboratory (NERBL) was established in 2008 with the goal of ensuring that research and tasks in response to pathogens of pandemic potential and other emerging infections (PPP/EI) are safely, efficiently, and rigorously accomplished. The NERBL was also designed to serve as a regional resource for academic and industry partners engaged in activities that yield knowledge and medical countermeasures to PPP/EI and ready to serve as directed by NIH/NIAID/federal partners in whatever capacity necessary for pandemic response. A critical element necessary for effective functioning of any biosafety/biocontainment laboratory is the existence of core competencies associated with physical, operational, regulatory and research (vivarium/laboratory) tasks frequently performed in this setting. Individuals working in the context of biocontainment must possess advanced technical skills, have undergone extensive BSL-3/ABSL-3 training, and continuously enhance their knowledge regarding agent specific risk. Additionally, to maintain operational integrity of a biocontainment facility and adequately safeguard the staff, environment, and local community, functional redundancies in these skills and associated responsibilities are an absolute necessity. As such, the primary objective of this application is to expand and maintain a footprint of highly qualified staff within the NERBL that possess a set of core competencies for specific function categories (i.e., vivarium, facilities), while also cross-trained to undertake additional responsibilities should the need arise. Accordingly, we have proposed three Cores within the context of this application to achieve this overarching goal. Core 1 will oversee facility management, maintenance and operations, ensuring integrity and sustainability of the NERBL infrastructure. Core 2 will entail activities that cover BSL3/ABSL3 best practices, including laboratory specific biosafety, biosecurity education, vivarium specific trainings and research competencies. Lastly, Core 3 will serve as the biocontainment research support services core, expanding capacities for bacteriology, virology and vector biology. Core members will undergo rigorous cross-training to create the functional redundancies necessary for ensuring continuity of services. Together, these activities will allow us to fulfill our mission as a resource for Tufts University, academic partners, industry entities, state/federal investigators, as well as for our RBL/NBL Network members. Importantly, following completion of the stated milestones, the NERBL will be well-positioned and sufficiently resourced to rapidly respond to future emerging infectious disease threats.

项目概要-总体 新英格兰地区生物安全实验室（NERBL）成立于2008年，其目标是确保 这些研究和任务是为了应对潜在的大流行病原体和其他新出现的感染 (PPP/EI）安全、高效、严格地完成。NERBL也被设计成一个 为学术界和工业界合作伙伴提供区域资源， 对PPP/EI的对策，并准备在NIH/NIAID/联邦合作伙伴的指导下以任何身份提供服务 这是应对大流行的必要条件。任何机构有效运作所必需的一个关键因素是， 生物安全/生物防护实验室是与物理， 在这种环境下经常执行的操作、监管和研究（动物园/实验室）任务。 从事生物防护工作的个人必须具备先进的技术技能， 广泛的BSL-3/ABSL-3培训，并不断提高他们对代理特定风险的了解。 此外，为了保持生物防护设施的操作完整性并充分保护工作人员， 环境和当地社区，这些技能和相关责任的职能冗余， 这是绝对必要的因此，此应用程序的主要目标是扩展和维护 在NERBL内部拥有一系列核心能力的高素质员工的足迹， 特定功能类别（即，动物园，设施），同时也交叉培训，以承担额外的 必要时的责任。因此，我们在此背景下提出了三个核心， 应用程序来实现这一总体目标。核心1将监督设施管理、维护和 确保NERBL基础设施的完整性和可持续性。核心2所需的活动 涵盖BSL 3/ABSL 3最佳实践，包括实验室特定生物安全、生物安全教育、动物园 具体的培训和研究能力。最后，核心3将作为生物遏制研究 支持服务核心，扩大细菌学、病毒学和病媒生物学的能力。核心成员将 进行严格的交叉培训，以建立必要的职能冗余，确保 服务总之，这些活动将使我们能够履行我们的使命作为塔夫茨大学的资源， 学术合作伙伴、行业实体、州/联邦调查人员以及我们的RBL/NBL网络 成员重要的是，在完成所述里程碑之后，NERBL将处于有利地位， 有足够的资源来迅速应对未来新出现的传染病威胁。