Genomic mechanisms of violent juvenile aggression

青少年暴力攻击的基因组机制

基本信息

批准号：
10794603
负责人：
Eva K Fischer
金额：
$ 1.09万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-15 至 2027-07-31
项目状态：
未结题

项目摘要

PROJECT SUMMARY Violent aggressive behavior in children has life-long consequences for perpetrators, victims, their families, and society. Yet the biological bases of juvenile aggression remain largely unknown. This gap in knowledge persists due to a lack of tractable models in which juvenile aggression can be readily observed and manipulated. The proposed project takes an innovative, integrative approach to address this pressing knowledge gap using a novel animal model. Alongside the experimental tractability of classic fish and amphibian models, poison frog juveniles are highly aggressive, providing a powerful opportunity to understand the genomic bases of juvenile aggression. We test the central hypothesis that distinct mechanisms mediate the acute performance of, propensity for, and consequences of aggressive experiences. We pursue two complementary research directions to (1) uncover the mechanistic bases of individual variation and developmental shifts in aggression, and (2) probe the genomic and behavioral consequences of aggressive experiences for both perpetrators and victims. To optimize risk and reward, we tackle these questions from multiple angles, combining unbiased, exploratory approaches with characterization and manipulation of canonical candidates important for social behavior across vertebrates, including humans. Experiences of aggression have long-lasting individual and societal consequences and mechanistic research will have a significant positive impact by illuminating causes, consequences, and potential treatments for violent aggression among the youngest members of our society.

项目摘要儿童的暴力侵略行为对肇事者，受害者，他们的家人以及社会。然而，少年侵略的生物基础仍然很大未知。知识的差距仍然存在由于缺乏可容易观察和操纵少年侵略的模型。这拟议的项目采用创新的，综合的方法来解决这种紧迫的知识差距动物模型。除了经典鱼类和两栖动物模型的实验性障碍之外，有毒青蛙少年高度侵略性，为了解青少年侵略的基因组基础提供了有力的机会。我们检验了一个中心假设，即不同的机制介导了急性性能，倾向和积极经历的后果。我们追求两个互补的研究指示（1）个体变异和侵略性变化的机械基础，以及（2）探测基因组和肇事者和受害者的侵略性经历的行为后果。优化风险和奖励，我们从多个角度解决了这些问题，将公正的探索方法与对脊椎动物的社会行为重要的规范候选人的表征和操纵，包括人类。侵略经历具有长期的个人和社会后果，并且机械研究将通过阐明原因，后果和潜力产生重大的积极影响在我们社会中最年轻的成员中暴力侵略的治疗方法。