Genomic mechanisms of violent juvenile aggression

青少年暴力攻击的基因组机制

• 批准号: 10794603
• 负责人: Eva K Fischer
• 金额: $ 1.09万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10794603
• 关键词: Acute; Address; Adolescent; Aggressive behavior; Amphibia; Animal Model; Behavioral; Biological; Biological Models; Child; Development; Disease; Family; Fishes; Genomics; Human; Individual; Knowledge; Mediating; Modeling; Outcomes Research; Performance; Poison; Public Health; Rana; Research; Rewards; Risk; Social Behavior; Societies; Testing; Vertebrates; Violence; Work; base; comorbidity; experience; individual variation; innovation; member; novel; perpetrators

PROJECT SUMMARY Violent aggressive behavior in children has life-long consequences for perpetrators, victims, their families, and society. Yet the biological bases of juvenile aggression remain largely unknown. This gap in knowledge persists due to a lack of tractable models in which juvenile aggression can be readily observed and manipulated. The proposed project takes an innovative, integrative approach to address this pressing knowledge gap using a novel animal model. Alongside the experimental tractability of classic fish and amphibian models, poison frog juveniles are highly aggressive, providing a powerful opportunity to understand the genomic bases of juvenile aggression. We test the central hypothesis that distinct mechanisms mediate the acute performance of, propensity for, and consequences of aggressive experiences. We pursue two complementary research directions to (1) uncover the mechanistic bases of individual variation and developmental shifts in aggression, and (2) probe the genomic and behavioral consequences of aggressive experiences for both perpetrators and victims. To optimize risk and reward, we tackle these questions from multiple angles, combining unbiased, exploratory approaches with characterization and manipulation of canonical candidates important for social behavior across vertebrates, including humans. Experiences of aggression have long-lasting individual and societal consequences and mechanistic research will have a significant positive impact by illuminating causes, consequences, and potential treatments for violent aggression among the youngest members of our society.

项目摘要 儿童的暴力攻击行为对肇事者、受害者、他们的家庭和他们的父母都有终身的影响。 社会然而，青少年攻击性的生物学基础在很大程度上仍然未知。这种知识差距仍然存在 这是因为缺乏易于观察和操纵青少年攻击行为的模型。的 拟议的项目采取创新的，综合的方法，以解决这一紧迫的知识差距，使用一种新的 动物模型除了经典鱼类和两栖动物模型的实验易处理性外， 具有高度攻击性，这为了解青少年攻击性的基因组基础提供了一个强有力的机会。 我们检验了中心假设，即不同的机制介导急性表现，倾向， 侵略性经验的后果。我们追求两个互补的研究方向（1）揭示 个体变异和攻击性发展变化的机制基础，以及（2）探索基因组和 行为后果的侵略经验的肇事者和受害者。优化风险， 奖励，我们从多个角度解决这些问题，结合公正的，探索性的方法， 对脊椎动物社会行为重要的典型候选者的表征和操纵， 包括人类遭受侵犯的经历会对个人和社会产生长期影响， 机械研究将通过阐明原因、后果和潜力产生重大的积极影响 治疗我们社会中最年轻的成员的暴力攻击。