IDeA National Resource for Quantitative Proteomics Supplement

IDeA 国家定量蛋白质组学补充资源

• 批准号: 10796571
• 负责人: Michael T Kinter
• 金额: $ 24.81万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-20 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10796571
• 关键词: Arkansas; Award; Bioinformatics; Biomedical Research; Computers and Advanced Instrumentation; Data; Data Analyses; Development; Disease; Education; Face; Funding; Goals; Human Resources; Infrastructure; Institution; Institutional support resources; Malignant Neoplasms; Mission; National Institute of General Medical Sciences; Oklahoma; Positioning Attribute; Proteomics; Publications; Puerto Rico; Research; Research Personnel; Research Support; Resources; Sampling; Services; Training; Translational Research; United States; United States National Institutes of Health; base; bioinformatics resource; cost; fundamental research; human disease; instrument; instrumentation; model organism; outreach; programs; response; user-friendly

ABSTRACT Through PAR-19-301, NIGMS seeks to support mission relevant resources that will have the economy of scale to provide increased access to state-of-the-art services for a substantial regional or national user base. In response, we are applying for NIGMS National Resource support for the IDeA National Resource for Quantitative Proteomics. This resource was created in 2016 using NIGMS-funding from the IDeA (Institutional Development Award) Program that supports research in 23 states and Puerto Rico that have historically received lower levels of NIH funding. The IDeA National Resource for Quantitative Proteomics was created by regional consolidation of instrumentation, proteomics expertise, and associated bioinformatics resources across Arkansas and Oklahoma. The resource was created because IDeA investigators across the United States can face specific challenges for accessing cutting-edge proteomics resources and bioinformatics expertise for data interpretation. These challenges include the cost of rapidly advancing instrumentation, availability of the personnel expertise those instruments demand, and access to bioinformaticians trained in proteomics. Arkansas and Oklahoma were positioned to unify their respective infrastructures to fill these resource gaps and provide a comprehensive solution for quantitative proteomics to the IDeA network. Our resource has had three years to become fully established and reach economy of scale. We have served a diverse set of IDeA investigators for their NIGMS relevant research, ranging from studies on model organisms to diseases such as cancer. The goal of this proposal is to transition the IDeA National Resource for Quantitative Proteomics to a NIGMS National Resource in order to expand our ability to serve the quantitative proteomics needs of the IDeA network. We will continue to provide user-friendly services for state-of-the-art, quantitative proteomics that will guide the user from service request to sophisticated bioinformatics analysis to delivery of publication ready data. This resource will continue to support the biomedical research mission of NIGMS and NIH for both fundamental and translational research focused on human diseases including cancer. We will use the following Specific Aims to accomplish our goal: 1) Provide state-of-the-art quantitative proteomics services to the IDeA network, 2) Provide outreach opportunities for quantitative proteomics to the IDeA network, and 3) Provide educational opportunities for quantitative proteomics to the IDeA network.

摘要 通过PAR-19-301，NIGMS寻求支持使命相关资源， 扩大规模，为大量区域或国家用户提供更多获得最新服务的机会。在 响应，我们正在申请NIGMS国家资源支持IDEA国家资源定量 蛋白质组学该资源于2016年创建，使用来自IDEA（机构发展）的NIGMS资金 Award）支持23个州和波多黎各研究的计划，这些州和波多黎各在历史上获得了较低的水平 NIH的资助。IDEA定量蛋白质组学国家资源是通过区域整合创建的 仪器，蛋白质组学专业知识和相关的生物信息学资源在阿肯色州和 俄克拉荷马州。创建该资源是因为美国各地的IDEA调查人员可能面临特定的 获取尖端蛋白质组学资源和生物信息学专业知识进行数据解释的挑战。 这些挑战包括快速发展的仪器的成本，专业人员的可用性， 这些工具需要和获得经过蛋白质组学培训的生物信息学家。阿肯色州和俄克拉荷马州 能够统一各自的基础设施，以填补这些资源缺口，并提供全面的 定量蛋白质组学的解决方案到IDEA网络。我们的资源已经有三年的时间来充分利用 建立并达到规模经济。我们为各种IDEA调查人员提供了NIGMS服务 相关研究，从模式生物研究到癌症等疾病研究。这个目标 建议将定量蛋白质组学的IDEA国家资源转换为NIGMS国家资源 为了扩大我们的能力，以满足IDEA网络的定量蛋白质组学需求。我们将继续 为最先进的定量蛋白质组学提供用户友好的服务， 要求进行复杂的生物信息学分析，以提供可供出版的数据。这一资源将继续 支持NIGMS和NIH在基础研究和转化研究方面的生物医学研究使命 专注于包括癌症在内的人类疾病。我们将使用以下具体目标来实现我们的目标：1） 为IDEA网络提供最先进的定量蛋白质组学服务，2）提供推广机会 为定量蛋白质组学的IDEA网络，和3）提供教育机会， 蛋白质组学到IDEA网络。

项目成果

SILAC Phosphoproteomics Reveals Unique Signaling Circuits in CAR-T Cells and the Inhibition of B Cell-Activating Phosphorylation in Target Cells.

• DOI: 10.1021/acs.jproteome.1c00735
• 发表时间: 2022-02-04
• 期刊: Journal of proteome research
• 影响因子: 4.4
• 作者: Griffith AA;Callahan KP;King NG;Xiao Q;Su X;Salomon AR
• 通讯作者: Salomon AR

Antiviral responses in a Jamaican fruit bat intestinal organoid model of SARS-CoV-2 infection.

• DOI: 10.1038/s41467-023-42610-x
• 发表时间: 2023-10-28
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Hashimi, Marziah;Sebrell, T. Andrew;Hedges, Jodi F.;Snyder, Deann;Lyon, Katrina N.;Byrum, Stephanie D.;Mackintosh, Samuel G.;Crowley, Dan;Cherne, Michelle D.;Skwarchuk, David;Robison, Amanda;Sidar, Barkan;Kunze, Anja;Loveday, Emma K.;Taylor, Matthew P.;Chang, Connie B.;Wilking, James N.;Walk, Seth T.;Schountz, Tony;Jutila, Mark A.;Bimczok, Diane
• 通讯作者: Bimczok, Diane

Lipid environment modulates processivity and kinetics of a presenilin homolog acting on multiple substrates in vitro.

• DOI: 10.1016/j.jbc.2023.105401
• 发表时间: 2023-12
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Wu, Yuqi;Thomas, Gwendell M.;Thomsen, Max;Bahri, Sara;Lieberman, Raquel L.
• 通讯作者: Lieberman, Raquel L.

Neoplastic signatures: Comparative proteomics of canine hepatobiliary neuroendocrine tumors to normal niche tissue.

• DOI: 10.1371/journal.pone.0280928
• 发表时间: 2023
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Batts, Tifini L.;Sasaki, Emi W.;Miller, Mayzie;Sparago, Joshua;Bauer, Rudy W.;Paulsen, Daniel D.;Boudreaux, Bonnie N.;Liu, Chin-Chi;Byrum, Stephanie D.;Johnston, Andrea N.
• 通讯作者: Johnston, Andrea N.

Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer.

• DOI: 10.1016/j.biopha.2022.113440
• 发表时间: 2022-09
• 期刊: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie