IDeA National Resource for Quantitative Proteomics

摘要 通过PAR-19-301，NIGMS寻求支持特派团相关资源，这些资源将具有 扩大规模，为庞大的地区或国家用户群提供更多获得最先进服务的机会。在……里面 回应，我们正在申请NIGMS国家资源支持的想法国家资源的量化 蛋白质组学。该资源创建于2016年，使用NIGMS-Funding From the IDEA(机构发展 奖)计划，支持23个州和波多黎各的研究，这些州和波多黎各历史上接受的水平较低 美国国立卫生研究院的资金。国家定量蛋白质组学资源的构想是通过区域整合而产生的 阿肯色州和阿肯色州的仪器、蛋白质组专业知识和相关生物信息学资源 俄克拉荷马州。之所以创建该资源，是因为全美的IDEA调查人员可以面临特定的 获取尖端蛋白质组学资源和生物信息学专业知识以进行数据解释的挑战。 这些挑战包括快速发展的仪器设备的成本、人员专业知识的可用性 这些仪器需要有受过蛋白质组学培训的生物信息学家。阿肯色州和俄克拉何马州 定位于统一其各自的基础设施，以填补这些资源缺口并提供全面的 针对IDEA网络的定量蛋白质组学解决方案。我们的资源有三年的时间来充分利用 建立并达到规模经济。我们已经为各种各样的IDEA调查人员提供了他们的NIGMS 相关研究，从模型生物的研究到癌症等疾病的研究。这样做的目的是 建议将数量蛋白质组学国家资源的想法转化为NIGMS国家资源 为了扩大我们的能力，以服务于IDEA网络的定量蛋白质组学需求。我们将继续 为最先进的定量蛋白质组学提供用户友好的服务，这将引导用户从服务 要求进行复杂的生物信息学分析，以交付可供发布的数据。此资源将继续 支持NIGMS和NIH的基础研究和翻译研究的生物医学研究任务 专注于包括癌症在内的人类疾病。我们将通过以下具体目标来实现我们的目标：1) 为Idea网络提供最先进的定量蛋白质组学服务，2)提供推广机会 为定量蛋白质组学的构思网络，以及3)提供定量教育机会 从蛋白质组学到思想网络。

ABSTRACT Through PAR-19-301, NIGMS seeks to support mission relevant resources that will have the economy of scale to provide increased access to state-of-the-art services for a substantial regional or national user base. In response, we are applying for NIGMS National Resource support for the IDeA National Resource for Quantitative Proteomics. This resource was created in 2016 using NIGMS-funding from the IDeA (Institutional Development Award) Program that supports research in 23 states and Puerto Rico that have historically received lower levels of NIH funding. The IDeA National Resource for Quantitative Proteomics was created by regional consolidation of instrumentation, proteomics expertise, and associated bioinformatics resources across Arkansas and Oklahoma. The resource was created because IDeA investigators across the United States can face specific challenges for accessing cutting-edge proteomics resources and bioinformatics expertise for data interpretation. These challenges include the cost of rapidly advancing instrumentation, availability of the personnel expertise those instruments demand, and access to bioinformaticians trained in proteomics. Arkansas and Oklahoma were positioned to unify their respective infrastructures to fill these resource gaps and provide a comprehensive solution for quantitative proteomics to the IDeA network. Our resource has had three years to become fully established and reach economy of scale. We have served a diverse set of IDeA investigators for their NIGMS relevant research, ranging from studies on model organisms to diseases such as cancer. The goal of this proposal is to transition the IDeA National Resource for Quantitative Proteomics to a NIGMS National Resource in order to expand our ability to serve the quantitative proteomics needs of the IDeA network. We will continue to provide user-friendly services for state-of-the-art, quantitative proteomics that will guide the user from service request to sophisticated bioinformatics analysis to delivery of publication ready data. This resource will continue to support the biomedical research mission of NIGMS and NIH for both fundamental and translational research focused on human diseases including cancer. We will use the following Specific Aims to accomplish our goal: 1) Provide state-of-the-art quantitative proteomics services to the IDeA network, 2) Provide outreach opportunities for quantitative proteomics to the IDeA network, and 3) Provide educational opportunities for quantitative proteomics to the IDeA network.