Integrated Public Health and Academic Collaboration for Infectious Diseases Control (iPHAC-IDC): Implementation of One Health approaches to pandemic preparedness and adolescent HIV prevention

项目摘要/摘要 包括新发传染病(EID)在内的公共卫生威胁凸显了加强 监测和实验室系统，以更快、更智能地应对疫情。泰国部 疾病控制(DDC)，公共卫生部医学科学司(DMSc) 与朱拉隆功大学(CU)和泰国红十字会(TRC)合作应对艾滋病毒 研究和其他新兴地方性传染病监测、预防和控制。这项建议 将推出“综合公共卫生与学术合作以控制传染病”计划- 国际数据中心)：实施预防大流行和预防青少年艾滋病毒的统一健康办法“， 来自DDC、DMSc、CU和TRC的传染病控制研究人员之间的协作嵌套网络， 以及美国和法国的宰牲节专家。IPHAC-IDC将建立一个综合和可持续的 网络，为泰国未来的疾病爆发做好准备。我们将进行研究，以1)开发和 利用下一代聚合酶链式反应实施下一代公共卫生监测方法 测序和多重血清学分析以识别新病毒，表征新稀有病毒的基因组 地方性疾病的病毒株、EID和AMR。这些基因组数据将与临床和 流行病学数据，创建病原体基因组监测平台。此外，基因组数学 模型将被开发并嵌入到平台中进行实时分析。一次健康监测 环境中的方法，包括废水和空气，以及SARS-CoV-2在野生动物中逆转人畜共患病 将会被追查。2)在全球卫生学院开发和实施GLLP课程，创建一个 朱拉隆功大学医学院的GLLP课程，分两种模式；必修课 医学计划的一个健康分部的课程和其他毕业生的选修课 学生和所有参与者的终身学习平台，可以选择保留学分以备将来申请 在进入CU后。3)在政府医院发展以青少年为重点的爱滋病预防服务模式 通过建立以青年为重点的诊所，提供全面的艾滋病毒教育和预防，建立网络 暴露前预防利用社会网络策略，并改进淋病抗菌剂 基因组耐药监测。 这项研究将增进我们对EIDs和地方病风险的了解，并加强对EID和地方病的认识。 国家公共卫生研究能力和促进应对大流行的实验室队伍建设 防备和青少年艾滋病毒预防。

PROJECT SUMMARY/ABSTRACT Public health threats including emerging infectious diseases (EIDs) have highlighted the need for strengthening surveillance and laboratory systems for faster and smarter outbreak response. The Thai Department of Diseases Control (DDC), the Department of Medical Sciences (DMSc), Ministry of Public Health have collaboratively worked with Chulalongkorn University (CU) and the Thai Red Cross Society (TRC) on HIV research and other emerging endemic infectious disease surveillance, prevention, and control. This proposal will launch the “Integrated Public Health and Academic Collaboration for Infectious Diseases Control (iPHAC- IDC): Implementation of One Health approaches to pandemic preparedness and adolescent HIV prevention”, a collaborative nested network among infectious disease control researchers from DDC, DMSc, CU and TRC, as well as EID experts in the USA and France. The iPHAC-IDC will establish an integrated and sustainable network to prepare for future disease outbreaks in Thailand. We will conduct research to 1) Develop and implement the NextGen Public Health Surveillance Approaches by using the PCR, next-generation sequencing, and multiplex serology assays to identify novel viruses, characterize the genomes of new-rare viral strains of endemic diseases, EIDs, and AMR. These genomic data will be integrated with clinical and epidemiologic data to create a pathogen genomic surveillance platform. In addition, genomic-mathematic models will be developed and embedded in the platform for real-time analysis. One Health surveillance approaches in the environment, including wastewater and air, and SARS-CoV-2 reverse zoonoses in wildlife will be pursued. 2) Develop and implement the GLLP curriculum at the School of Global Health by creating a GLLP curriculum at the Faculty of Medicine, Chulalongkorn University, in two pattern courses; A mandatory course in the One Health Branch of the Medical Sciences program and an elective course for other graduate students and a lifelong learning platform for all participants with an option to keep the credits for further claims after enrollment to CU. 3) Develop a youth-focused HIV prevention service model in the government hospital network by establishing youth-focused clinics that provide comprehensive HIV education and prevention with pre-exposure prophylaxis leveraging social network strategies, and improving gonorrhea antimicrobial genomics resistance surveillance. This research will advance our understanding of the risk of EIDs and endemic diseases and strengthen in- country public health research capacity and promote laboratory workforce development for pandemic preparedness and adolescent HIV prevention.