Cognitive Reappraisal for Mitigating Incubation of Cocaine Cue-Reactivity
减轻可卡因线索反应潜伏期的认知重新评估
基本信息
- 批准号:10812738
- 负责人:
- 金额:$ 81.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-30 至 2028-08-31
- 项目状态:未结题
- 来源:
- 关键词:AbstinenceAccountingAffectAffectiveAftercareAlcoholsArousalAttentionAttenuatedBackBehavior TherapyBehavioralCOVID-19 pandemicCessation of lifeChronicClinicClinicalClinical ResearchCocaineCocaine UsersCocaine use disorderCognitiveControl GroupsCross-Sectional StudiesCuesDataDown-RegulationDrug AddictionDrug usageElectroencephalographyEnrollmentEvidence based interventionExposure toFoundationsIncubatedIndividualInterventionLongitudinal StudiesMeasuresMediatingMinorityNeurocognitiveOutcomeOutcome MeasureParticipantPatient Self-ReportPharmaceutical PreparationsPopulationPrediction of Response to TherapyProceduresProcessRandomizedRegulationRelapseReportingResearchResearch PersonnelSmokerSubstance Use DisorderSurveysTechniquesTestingTimeTrainingUnited Statesaddictionattentional biasclinical effectclinical outcome assessmentclinically significantcocaine cuecocaine overdosecocaine relapse preventioncocaine usecognitive processcognitive reappraisalcomparison controlcravingcue reactivitydrug seeking behavioremotion regulationfollow-upgazehuman studyimprovedinnovationnoveloutcome predictionpredict clinical outcomeprolonged abstinencepublic health emergencyrandomized, controlled studyreduced substance userelapse predictionrelapse preventionsubstance usetreatment researchtreatment responsevisual tracking
项目摘要
SUMMARY
Cocaine use is endemic nationwide. According to a national survey, over 2.5% of the population of individuals
12 years and older reported crack or cocaine use in the past year, accounting for over 10,000 deaths related to
cocaine overdose. Recent data suggests that the COVID-19 pandemic has exacerbated substance use in the
United States. Only a small minority of cocaine users seek formal treatment for their addiction, and even in those
who do, the relapse rate remains disturbingly high with some studies reporting rates as high as 90%, 12 months
after treatment. Relapse in addicted individuals is presumed to precipitate from the re-exposure to cues that
were previously associated with drug use. Over the course of chronic drug use, these cues are afforded
enhanced attention (or attention-bias), which has shown to promote motivated arousal, culminating in compulsive
drug-seeking or relapse. We have used the late positive potential (LPP), an EEG-derived marker of motivated
arousal to show that, unlike commonly believed, arousal to drug cues (or cue-reactivity) increases (or incubates)
during the first six months of abstinence. Such incubation of cue-reactivity is posited to confer disproportionately
high relapse vulnerability in addicted individuals. Our recently acquired follow-up data show that addicted
individuals are able to down-regulate drug cue-reactivity (as evident via a decrease in LPP amplitude) via
cognitive reappraisal (an emotion-regulation technique) training, which then leads to a reduction in spontaneous
attention-bias to drug cues (quantified using eye-tracking). Here, we propose to integrate the two pieces of
evidence to test whether cognitive reappraisal training can reduce the incubation of drug cue-reactivity (Aim 1)
and improve clinical outcomes (e.g., reduce craving and prolong cocaine abstinence duration; Aim 2) during the
first 6 months of abstinence in individuals with cocaine use disorder (iCUD). We will further explore whether
changes in attention-bias to drug cues and/or blunting of incubation of cue-reactivity tracks treatment response
and predicts clinical outcomes at 6 months follow-up (exploratory aim). For this purpose, we propose to enroll
126 iCUD, half of whom will be randomized to undergo cognitive reappraisal training and the other half will
instead complete a control task. In this longitudinal study, participants will complete these procedures at 1-week,
1-, 3-, and 5-months post abstinence initiation, and will then come back one month after (at 6 months post
abstinence initiation) for the assessment of clinical outcomes. Thus, this novel study aims to bridge between the
lab and the clinic by advancing basic mechanistic understanding of a novel evidence-based intervention to
provide cognitive markers for tracking treatment response and predicting outcomes in addiction. Successful
completion of this study would lay the foundation for further basic and clinical studies that will examine other
putative mechanisms and potentially also use the same framework for the neurocognitive examination of similar
cognitive interventions in other substance use disorders as well as in other behavioral addictions.
总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Muhammad Adeel Parvaz其他文献
Muhammad Adeel Parvaz的其他文献
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{{ truncateString('Muhammad Adeel Parvaz', 18)}}的其他基金
Cue Reactivity Modulation in MSM with Methamphetamine Use Disorder
甲基苯丙胺使用障碍 MSM 的提示反应性调节
- 批准号:
10663559 - 财政年份:2023
- 资助金额:
$ 81.59万 - 项目类别:
Characterization of Reward Processing in Adolescent Marijuana Use
青少年大麻使用奖励处理的特征
- 批准号:
9904607 - 财政年份:2018
- 资助金额:
$ 81.59万 - 项目类别:
Characterization of Reward Processing in Adolescent Marijuana Use
青少年大麻使用奖励处理的特征
- 批准号:
10363708 - 财政年份:2018
- 资助金额:
$ 81.59万 - 项目类别:
BCI-based feedback system to promote cognitive control of craving
基于BCI的反馈系统促进对渴望的认知控制
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8738037 - 财政年份:2012
- 资助金额:
$ 81.59万 - 项目类别:
BCI-based feedback system to promote cognitive control of craving
基于BCI的反馈系统促进对渴望的认知控制
- 批准号:
8792615 - 财政年份:2012
- 资助金额:
$ 81.59万 - 项目类别:
BCI-based feedback system to promote cognitive control of craving
基于BCI的反馈系统促进对渴望的认知控制
- 批准号:
8398514 - 财政年份:2012
- 资助金额:
$ 81.59万 - 项目类别:
BCI-based feedback system to promote cognitive control of craving
基于BCI的反馈系统促进对渴望的认知控制
- 批准号:
8763930 - 财政年份:2012
- 资助金额:
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