Characterization of Reward Processing in Adolescent Marijuana Use

青少年大麻使用奖励处理的特征

基本信息

批准号：
10363708
负责人：
Muhammad Adeel Parvaz
金额：
$ 16.45万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-04-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10363708
关键词：
Adolescence Adolescent Adolescent marijuana use Adult Alcohols Anhedonia Anterior Anxiety Disorders Behavior Biometry Brain Brain imaging Cannabis sativa plant Child Childhood Clinical Cocaine Dependence Cocaine use disorder Competence Corpus striatum structure Data Development Dimensions Disease Dorsal Electroencephalography Environment Exhibits Feedback Foundations Functional Magnetic Resonance Imaging Functional disorder Gambling Goals Hippocampus (Brain)Illicit Drugs Impairment Interview Joints Link Long-Term Effects Marijuana Measures Mentored Research Scientist Development Award Mentors Minority Mood Disorders National Institute of Drug Abuse Neuraxis Neurobiology Neurocognitive Outcome Participant Patient Self-Report Pharmaceutical Preparations Pharmacology Phase Population Process Psychopathology Reporting Research Research Project Grants Research Training Rest Rewards Risk Sampling Scientist Severities Testing Training Ventral Striatum Work Youth addiction adolescent substance use adverse outcome base behavior test biomarker identification brain dysfunction career career development child depression cingulate cortex clinical outcome assessment clinical predictors clinically relevant cognitive development drug of abuse experience experimental study follow up assessment follow-up functional MRI scan functional disability illicit drug use imaging facilities indexing innovation marijuana use marijuana use disorder marijuana user medical schools multidisciplinary multimodal neuroimaging neural circuit neurobehavioral neurobiological mechanism neuroimaging neuroimaging marker neuromechanism neuronal circuitry neurophysiology neuropsychiatry novel phenomenological models pleasure predict clinical outcome predictive marker programs reward anticipation reward circuitry reward expectancy reward processing stem stressor substance use symptomatology task analysis translational potential twelfth grade

项目摘要

PROJECT SUMMARY/ABSTRACT Adolescence is a vulnerable developmental stage where significant changes occur in a youth’s central nervous system. Pharmacological stressors, such as drugs of abuse, can have a profound impact on these changes during adolescence. Marijuana (MJ), second to alcohol, is the most widely used intoxicant in adolescents. A staggering 36% high-school seniors reported using MJ in the past year and 21% in the past month. Of course, many adolescents who experiment with MJ only do so during adolescence and experience little to no long-term effects. Nonetheless, a significant minority does experience problems and their initial MJ experimentation can escalate to extremely adverse outcomes including addiction and other psychiatric conditions. However, the precise neurobiological underpinnings of such transition is not well-understood, but are posited to be associated with reward dysfunction. During the K01 award period, the Candidate will pursue an innovative line of research examining the impact of initial MJ use on reward processing in adolescent MJ users, while also receiving essential training required to conduct such research. Specifically, the project will examine neural mechanisms underpinning reward dysfunction in adolescent MJ users via multimodal neuroimaging [electroencephalography (EEG) and a functional magnetic resonance imaging (fMRI)], and test whether these neuroimaging markers predict escalation of disease symptomology at 12-month follow-up. Embedded within this novel project are clear training aims, which will be implemented with guidance from a multidisciplinary mentoring team of renowned research scientists. The proposed training plan will develop competency in (1) clinical characterization of adolescent substance use; (2) utilization of fMRI to study reward circuity; and (3) advance biostatistics for clinical outcome assessment. At baseline, MJ-using adolescents and MJ-naïve control adolescents will perform tasks that probe reward anticipation and attainment stages of reward processing, separately with EEG and fMRI. Participants will also undergo a resting-state fMRI scan for precise delineation of the neuronal circuitry underlying reward processing. Lastly, participants will return 12 months after baseline for a clinical follow-up. The goal is to investigate whether baseline neuroimaging markers of reward dysfunction predict escalation in substance use symptomatology. Importantly, Icahn School of Medicine at Mount Sinai is an ideal environment to conduct neuroimaging research with children and adolescents, as it boasts fully-equipped Pediatric Mood and Anxiety Disorders Program (P-MAP; Chief: Dr. Gabbay) to conduct interviews and behavioral testing, and the Brain Imaging Center (BIC; Chief: Dr. Goldstein) for EEG and fMRI scanning. Collectively, the proposed research and training goals will provide the Candidate with a strong foundation in adolescent psychopathological assessment and functional neuroimaging, facilitate in launching his independent research career, while also significantly advancing our understanding of neurocognitive mechanisms underlying adolescent substance use.

项目摘要/摘要青少年是一个脆弱的发育阶段，在青年中心紧张中发生重大变化系统。药理学压力源（例如滥用药物）可能会对这些变化产生深远的影响在青少年期间。大麻（MJ）以酒精为名，是青少年中使用最广泛的醉酒。一个在过去的一年中，惊人的36％高中生报告说使用了MJ，在过去一个月中使用了21％。当然，许多尝试MJ的青少年仅在青少年期间才能做到这一点，几乎没有长期的经历效果。尽管如此，很大的少数确实会遇到问题，并且他们最初的MJ实验可以升级为极度不利的结果，包括成瘾和其他精神疾病。但是，这种过渡的精确神经生物学基础不是很好理解，而是被指定为关联带有奖励功能障碍。在K01奖励期间，候选人将追求创新的研究线检查初始MJ使用对青少年MJ用户中奖励处理的影响，同时也接收进行此类研究所需的基本培训。具体而言，该项目将检查神经机制通过多模式神经影像学[脑电图（EEG）和功能性磁共振成像（fMRI）]，并测试这些神经成像标记物是否预测在12个月随访中疾病症状的升级。嵌入在这个小说项目中很明确培训目标，将在众所周知的多学科指导团队的指导下实施研究科学家。拟议的培训计划将在（1）临床表征方面发展能力青少年使用物质；（2）利用fMRI研究奖励电路；（3）临床的生物统计学结果评估。在基线时，使用MJ使用的青少年和MJ-nevave Control青少年将执行任务该调查奖励预期和奖励处理的属性阶段，分别使用脑电图和fMRI。参与者还将接受静止状态fMRI扫描，以精确地描述神经元电路的精确描述奖励处理。最后，参与者将在基线后12个月返回临床随访。目标是调查奖励功能障碍的基线神经影像学标记是否可以预测物质使用的升级症状学。重要的是，西奈山的伊坎医学院是进行的理想环境与儿童和青少年进行神经影像学的研究，因为它具有齐全的儿科情绪和焦虑症疾病计划（P-MAP；首席：Gabbay博士）进行访谈和行为测试，大脑成像中心（BIC；首席：Goldstein博士）用于脑电图和fMRI扫描。总的来说，拟议的研究和培训目标将为候选人提供青少年心理病理学评估的坚实基础和功能性神经影像学，促进他的独立研究生涯，同时也很重要促进我们对使用青少年物质使用的神经认知机制的理解。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Social Isolation-Mediated Exacerbation of Negative Affect in Young Drinkers during the COVID-19 Pandemic.

DOI：
10.3390/brainsci12020214
发表时间：
2022-02-04
期刊：
Brain sciences
影响因子：
3.3
作者：
Neppala GK;Terkuhle I;Wagner A;Lepow L;Shaik RB;Freed R;Kimhy D;Pietrzak RH;Velthorst E;Feder A;Ivanov I;Parvaz MA
通讯作者：
Parvaz MA

Reward-Based Learning as a Function of Severity of Substance Abuse Risk in Drug-Naïve Youth with ADHD.

基于奖励的学习作为患有 ADHD 的未吸毒青少年药物滥用风险严重程度的函数。

DOI：
10.1089/cap.2018.0010
发表时间：
2018
期刊：
Journal of child and adolescent psychopharmacology
影响因子：
1.9
作者：
Parvaz,MuhammadA;Kim,Kristen;Froudist-Walsh,Sean;Newcorn,JeffreyH;Ivanov,Iliyan
通讯作者：
Ivanov,Iliyan

Habenula-prefrontal resting-state connectivity in reactive aggressive men - A pilot study.

DOI：
10.1016/j.neuropharm.2018.10.025
发表时间：
2019-09-15
期刊：
Neuropharmacology
影响因子：
4.7
作者：
Gan G;Zilverstand A;Parvaz MA;Preston-Campbell RN;d'Oleire Uquillas F;Moeller SJ;Tomasi D;Goldstein RZ;Alia-Klein N
通讯作者：
Alia-Klein N

A Meta-Analysis of fMRI Studies of Youth Cannabis Use: Alterations in Executive Control, Social Cognition/Emotion Processing, and Reward Processing in Cannabis Using Youth.

DOI：
10.3390/brainsci12101281
发表时间：
2022-09-23
期刊：
BRAIN SCIENCES
影响因子：
3.3
作者：
Hammond, Christopher J.;Allick, Aliyah;Park, Grace;Rizwan, Bushra;Kim, Kwon;Lebo, Rachael;Nanavati, Julie;Parvaz, Muhammad;Ivanov, Iliyan
通讯作者：
Ivanov, Iliyan

Neural mechanisms of extinguishing drug and pleasant cue associations in human addiction: role of the VMPFC.

DOI：
10.1111/adb.12545
发表时间：
2019-01
期刊：
Addiction biology
影响因子：
3.4
作者：
Konova AB;Parvaz MA;Bernstein V;Zilverstand A;Moeller SJ;Delgado MR;Alia-Klein N;Goldstein RZ
通讯作者：
Goldstein RZ