R35 Undergraduate Research Supplement

R35 本科生研究补充材料

• 批准号: 10810160
• 负责人: Kalev Freeman
• 金额: $ 1.21万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10810160
• 关键词: Acute; Biology; Blood; Blood Vessels; Blood flow; Clinical; Coagulation Process; Diagnosis; Disease; Endothelial Cells; Endothelium; Health; Health Care Costs; Histones; Impairment; Inflammation; Injury; Innate Immune Response; Intervention; Membrane; Research; Role; Signal Transduction; Surface; Syndrome; Testing; Translating; Trauma; Trauma patient; Vascular Endothelium; burden of illness; endothelial dysfunction; improved; improved outcome; molecular modeling; novel strategies; programs; response; response to injury; therapeutic evaluation; undergraduate research

Injury and trauma are common conditions that encompass a considerable burden of illness and account for a major component of health care costs. Endothelial cells (ECs) are the nexus between the blood and the body, and disruption of endothelial function in trauma leads to a syndrome of endothelipathy characterized by impaired microvascular blood flow, barrier integrity and coagulation. Our lack of understanding of how ECs translate the signals of trauma into changes in vasodilatory, barrier and coagulation functions represents a significant void— but also an opportunity for clinical intervention. The central theme of my lab is to understand endotheliopathy in trauma and inflammation, so that we can improve outcomes. This research program will deliver a molecular model of the mechanisms by which histones cause both immediate and sustained effects on vascular endothelium that explain oscillating clotting responses seen in trauma patients. This project will also test novel strategies to protect and/or rescue endothelial dysfunction after trauma. The proposed research is expected to significantly advance the continuum of research needed to improve diagnosis and management of acute endotheliopathy in trauma. Moreover, it has the potential to radically change our view of endothelial biology. This research will provide an enduring and sustained impact on understanding the role of the endothelium in health and disease.

伤害和创伤是常见的情况，包括相当大的疾病负担，并占一个