ENVIONMENTAL AGENTS IN THE INDUCTION OF AUTOIMMUNITY

诱导自身免疫的环境因素

• 批准号: 2018976
• 负责人: JOEL SCHIFFENBAUER
• 金额: $ 7.25万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2018976
• 关键词: autoantibody; autoimmune disorder; autoimmunity; cellular pathology; diabetes mellitus; environmental toxicology; estrogen analog; estrogen inhibitor; immunopathology; immunotoxicity; kidney disorder; laboratory mouse; lymphocyte proliferation; systemic lupus erythematosus

DESCRIPTION: The primary objective of this proposal is to examine the effect of environmental toxicants that possess either estrogenic or antiestrogenic properties on: (1) the course of lupus in one autoimmune strain of mice with lupus, (2) the course of autoimmunity in diabetes-prone and diabetes-resistant mice, and (3) the ability of these agents to induce autoimmune renal disease in two normal strains of mice. These objectives will be addressed by administering estrogenic and antiestrogenic agents to mice, and then evaluating the effect on the production of autoantibodies, B cell proliferation and development of autoimmune pathology in the kidney and pancreas.

描述：本提案的主要目的是检查