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CLASS II GENES IN AUTOIMMUNE ANIMALS

CLASS II GENES IN AUTOIMMUNE ANIMALS
自身免疫动物中的 II 类基因
批准号:
2063808
负责人:
JOEL SCHIFFENBAUER
金额:
$18.11万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1990
资助国家:
美国
项目状态:
已结题
起止时间:
1990-09-01 至 1995-07-31

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中文摘要
翻译
II类分子在正常和异常中都起着核心作用
英文摘要
The class II molecules play a central role in both normal and abnormal immune responses, and a number of autoimmune diseases both in man and mouse appear to be linked to class II molecules. We propose to evaluate the qualitative and quantitative contribution of the class II molecules from the NZW mouse strain to autoimmunity in the (NZWxNZB)F mouse. The qualitative structure function relationship of class II molecules in autoimmunity will be evaluated by seeking unusual sequences in NZW cDNA's. We will develop monoclonal antibodies specific for the NZW/NZB hybrid class II molecules to examine whether hybrid class II molecules exist in vivo, and determine if these hybrid molecules might contribute to the development of autoimmunity. Using transfections we will also determine whether the "u" haplotype is immunodominant, which would help explain the NZW contribution to accelerated autoimmunity. In addition, we plan to produce transgenic NZB mice, in which NZW class II transgenes are placed into NZB mice. To evaluate whether there is a quantitative contribution of class II molecules to autoimmunity, we will isolate NZB and NZW genes and examine both cis and trans acting factors which regulate the expression of class II genes. Cis acting factors will be evaluated by determining whether the 5' flanking region of the class II genes of NZW and NZB have unusual sequences. cDNA's encoding trans acting factors will be isolated by a Southwestern methodology whereby labeled oligonucleotides corresponding to the NZB and NZW 5' regulatory regions are used to probe NZB and NZW lambda gt11 libraries. These cDNA's will be examined for unusual sequences. These studies will evaluate both the quantitative and qualitative contributions of class II genes to autoimmunity.
期刊论文(3)
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科研奖励(0)
会议论文
Hyperproliferation of BXSB B cells is linked to the Yaa allele.
BXSB B 细胞的过度增殖与 Yaa 等位基因有关。
DOI: 10.1006/clin.1996.0170
发表时间: 1996
期刊: Clinical immunology and immunopathology
影响因子: --
作者: [DesJardin,LE, Butfiloski,EJ, Sobel,ES, Schiffenbauer,J]
通讯作者: Schiffenbauer,J
DOI: 10.1002/art.1780341111
发表时间: 1991
期刊: Arthritis and rheumatism
影响因子: --
作者: [Schiffenbauer,J, Wegrzyn,L]
通讯作者: Wegrzyn,L
Background genes mediate the development of autoimmunity in (NZB x PL/J)F1 or (NZB x BIO.PL)F1 mice.
背景基因介导 (NZB x PL/J)F1 或 (NZB x BIO.PL)F1 小鼠自身免疫的发展。
DOI: 10.1016/0090-1229(92)90076-z
发表时间: 1992
期刊: Clinical immunology and immunopathology
影响因子: --
作者: [Schiffenbauer,J, Wegrzyn,L, Croker,BP]
通讯作者: Croker,BP
Autoimmune toxicity of chlorinated compounds
  • 批准号:
    6664570
  • 项目类别:
  • 资助金额:
    $13.16万
  • 财政年份:
    2002
  • 负责人:
    JOEL SCHIFFENBAUER
  • 依托单位:
Autoimmune toxicity of chlorinated compounds
  • 批准号:
    6580398
  • 项目类别:
  • 资助金额:
    $13.16万
  • 财政年份:
    2002
  • 负责人:
    JOEL SCHIFFENBAUER
  • 依托单位:
Autoimmune toxicity of chlorinated compounds
  • 批准号:
    6443387
  • 项目类别:
  • 资助金额:
    $13.16万
  • 财政年份:
    2001
  • 负责人:
    JOEL SCHIFFENBAUER
  • 依托单位:
GENETIC LOCI CONTRIBUTING TO AUTOIMMUNITY IN BXSB MICE
  • 批准号:
    6201320
  • 项目类别:
  • 资助金额:
    $15.69万
  • 财政年份:
    1999
  • 负责人:
    JOEL SCHIFFENBAUER
  • 依托单位:
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