Detecting cancer early with targeted nano-probes for vascular signatures

利用针对血管特征的靶向纳米探针早期检测癌症

• 批准号: 7288295
• 负责人: DOUGLAS HANAHAN
• 金额: $ 61.52万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-29 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7288295
• 关键词: Adenocarcinoma; Anatomy; Animals; Binding; Biopsy; Blood; Blood Vessels; Cancerous; Carcinoma; Cardiovascular system; Cervical; Cervical dysplasia; Cervix Uteri; Cervix carcinoma; Clinical; Condition; Contrast Media; Devices; Diagnostic Neoplasm Staging; Ductal; Dysplasia; Early Diagnosis; Elements; Endocrine; Enhancement Technology; Female; Fluorine; Foundations; Functional Imaging; Future; Generations; Genetically Engineered Mouse; Goals; Home environment; Homing; Human; Image; Imaging technology; Institutes; Invasive; Islets of Langerhans; Lesion; Link; Lodine; Lymphangiogenesis; Lymphatic; Lymphatic vessel; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of pancreas; Molecular Probes; Mus; Nanostructures; Nanotechnology; Neoplasms; Non-Invasive Cancer Detection; Normal tissue morphology; Organ; Output; Pancreas; Pancreatic Ductal Adenocarcinoma; Pancreatic Intraepithelial Neoplasia; Peptides; Performance; Phage Display; Photons; Positron; Positron-Emission Tomography; Premalignant; Principal Investigator; Property; Radioisotopes; Reagent; Reporter; Reporting; Research; Resolution; Screening for cancer; Signal Transduction; Site; Specificity; Staging; Technetium 99m; Technology; Testing; Transgenic Mice; Tumor Angiogenesis; Tumor-Associated Vasculature; angiogenesis; base; cancer type; human disease; imaging probe; improved; innovation; molecular imaging; mouse model; nano; nanoimaging; nanoprobe; neoplastic; progenitor; prototype; research clinical testing; single photon emission computed tomography; targeted delivery; translational study; tumor; tumor progression; tumorigenesis

DESCRIPTION (provided by applicant): This project will develop targeted nano-probes for molecular imaging to enable non-invasive early detection of incipient cancer, affording substantive improvements in sensitivity and selectivity. It brings together three research groups with complementary expertise in angiogenesis and mouse models of cancer (Hanahan, UCSF), in vascular profiling (Ruoslahti, Burnham Institute), and in clinical and experimental molecular imaging (Franc, UCSF). Peptides have been discovered that specifically home through the circulatory system to the angiogenic blood or lymphatic neo-vasculature of high-grade neoplasias and/or invasive carcinomas. These vascular signatures can distinguish cancerous lesions from their cognate normal tissue, as well as from blood/lymphatic vessels in other organs and neoplastic conditions. The aims are: 1. Develop imaging nanoprobes for detecting the blood and lymphatic neo-vasculature in two mouse models of cancer that undergo stepwise progression to carcinoma, using validated signature-finding peptides as modular specificity elements linked to agents appropriate for imaging with SPECT, PET, or MRI. 2. Discover and characterize a repertoire of new signature-finding peptides for blood and lymphatic vasculature of cervical and pancreatic ductal neoplasias and cancer, and determine which identify analogous lesions in the cognate human diseases. 3. Competitively evaluate mouse/human signature-finding peptides (and mixtures thereof) from Aim 2 to identify the best at delivering imaging reporters to the aberrant blood and lymphatic vasculatures in the mouse models of cervical (as a prototype) and pancreatic ductal cancer (for its an unmet clinical need). 4. In partnership with Centers of Excellence in Cancer Nanotechnology, test nano-probes in the mouse models consisting of the best human/mouse signature-finding peptides linked to new imaging nanostructures being developed by those centers, to identify optimal candidate nanoprobes for clinical evaluation. The modular imaging nanoprobes to be developed, by delivering imaging agents to organ sites of tumor angiogenesis and lymphangiogenesis, hold promise to enable early detection of human cancer.

描述（由申请人提供）：