Gene-Environment Interations Underlying Alcoholism Vulne

童年的逆境往往早于诸如反社会行为等外在行为和诸如抑郁症等内在行为，这两者都是问题饮酒和酗酒的风险因素。我们使用的数据来自英国雅芳家长和儿童纵向研究（ALSPAC）中约7000名白人女孩和男孩的家长和教师自我报告问卷。招募了怀孕早期的母亲，并提供了关于她们8岁以下子女的数据。我们给孩子们做了基因分型？s DNA中的三个基因的功能多态性：单胺氧化酶A（MAOA），5-羟色胺转运蛋白（HTT）和儿茶酚-O-甲基转移酶（COMT）。我们正在研究基因-环境相互作用对酒精中毒脆弱性障碍发展的纵向影响。 我们已经发现，母亲的精神病理学经历的儿童在0岁？2年对行为，多动症和ADHD有显着影响，至少持续到8岁。在同一时间段内经历的压力性生活事件具有相同的影响，尽管影响力较小。我们发现MAOA VNTR变异和生活事件对行为的影响，特别是在男孩和女孩中的多动之间存在相互作用。进一步的分析正在进行中。HTT启动子多态性，HTTLPR，和生活事件之间的相互作用的初步分析表明情绪的影响。与此相反，初步分析的COMT Val 158 Met和生活事件的相互作用表明没有影响儿童的情绪。

Childhood adversity often pre-dates externalizing behaviors such as antisocial behavior and internalizing behaviors such as depression, both of which are risk factors for problem drinking and alcoholism. We are using data derived from parental and teacher self-report questionnaires in a cohort of approximately 7000 Caucasian girls and boys from the Avon Longitudinal Study of Parents and Children (ALSPAC), U.K. Mothers were recruited in early pregnancy and data is available on their children up to age 8. We have genotyped the children?s DNA for functional polymorphisms in three genes: monoamine oxidase A (MAOA), serotonin transporter (HTT) and catechol-O-methyltransferase (COMT). We are looking at the longitudinal influence of gene-environment interactions on the development of alcoholism vulnerability disorders. We have found that maternal psychopathology experienced by children at age 0 ? 2 years has a significant effect on conduct, hyperactivity and ADHD that persists at least until age 8. Stressful life events experienced during the same time frame has the same, although less powerful, influence. We have found an interaction between the MAOA VNTR variant and life events on behavior, particularly hyperactivity, in both boys and girls. Further analyses are underway. Preliminary analyses on the interaction between the HTT promoter polymorphism, HTTLPR, and life events indicate an influence on emotionality. In contrast, preliminary analyses of the interaction of the COMT Val158Met and life events indicate no influence on childhood emotionality.