权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Massage Therapy In Eccentric Exercise Induced Muscle Weakness And Inflammation

偏心运动引起的肌肉无力和炎症的按摩疗法

基本信息

批准号：
7890629
负责人：
Thomas Michael Best
金额：
$ 38.92万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7890629
关键词：
Actins Acupuncture procedure Acute Affect American Animal Model Anti-Inflammatory Agents Anti-inflammatory Articular Range of Motion Arts Athletic Basic Science Biological Biological Markers Biomechanics Bradykinin Calcitonin Gene-Related Peptide Cell Proliferation Cells Chronic Clinical Clinical Trials Clinical effectiveness Collagen Data Devices Dinoprostone Economic Burden Edema Effectiveness Enzymes Exercise Frequencies Functional disorder Future Gene Expression Genes Healed Health Human In Vitro Infiltration Inflammation Inflammatory Injury Interleukins Isometric Exercise Joints Leukocytes Ligaments Liver M-cadherin Massage Measures Mediator of activation protein Medical Membrane Modeling Molecular Muscle Muscle Cells Muscle Fibers Muscle Proteins Muscle Tension Muscle Weakness Muscle function Muscle strain Musculoskeletal Myalgia Myogenin Myosin Heavy Chains Oryctolagus cuniculus Pain Pathway interactions Patients Performance Pharmaceutical Preparations Pharmacologic Substance Phase Physicians Pilot Projects Process Proteolysis RNA Splicing Recovery Regimen Regulation Relative (related person)Research Signal Transduction Simulate Skeletal Muscle Somatomedins Spasm Sprain Staging Structural Protein Structure Substance P Swelling TNF gene Technology Testing Time Tissues Torque Tube Tumor Necrosis Factor-alpha Tumor Necrosis Factors Ubiquitin United States Variant Visit Weight Work Yoga analytical method base cyclooxygenase 2 cytokine design gene induction healing human NOS2A protein immunopathology improved in vivo inflammatory pain innovation joint function mRNA Expression macrophage meetings multicatalytic endopeptidase complex multidisciplinary muscle form muscle regeneration neutrophil novel protein degradation public health relevance regenerative repaired research study response success

项目摘要

DESCRIPTION (provided by applicant): Acute and chronic skeletal muscle pain and weakness are among the most common ailments in a general medical practice. While treating muscle weakness and pain with pharmaceutical drugs and traditional exercise regimens has met with some success, large numbers of people have turned to alternative approaches including myofacial release, massage, acupuncture, and yoga. According to the American Massage Therapy Association (AMTA, http://www.amtamassage.org) the benefits of massage on muscle include; relief of muscle tension and stiffness, faster healing of strained muscles and sprained ligaments, reduced muscle pain, swelling, and spasm, greater range of motion, and even enhanced athletic performance. Although at this time many claims are made about massage, there are only a few studies to support its use. Moreover, the biological mechanism(s) by which massage works are largely unknown. To this end, we have employed our well-established in vivo rabbit model of eccentric exercise- induced muscle inflammation and weakness that closely mimics muscle injuries in athletes to examine the efficacy of massage therapies. Pilot studies have shown that four sessions of daily massage (using a self-designed and fabricated device capable of producing repeatable loading) can improve recovery of muscle function up to 120% over than the control while at the same time reducing tissue inflammation. Our overall hypothesis is that biomechanical signals generated during massage therapies at the correct magnitude, duration, and frequency are, (i) potent anti- inflammatory signals that inhibit muscle inflammation by suppressing expression of proinflammatory mediators, and (ii) effective signals that augment muscle regeneration and repair by upregulating expression of genes essential for muscle cell proliferation and differentiation. Three aims will be investigated utilizing state of the art technologies and analytical methods to determine an optimal magnitude, duration, and frequency of massage to restore muscle function (peak isometric torque) while investigating the effects of this combination on the host inflammatory and regenerative and reparative responses. This multidisciplinary effort will hopefully provide a strong rationale for future mechanistic studies and eventually clinical trials investigating the optimal indications and strategies for massage therapies to restore skeletal muscle dysfunction and improve overall human health. PUBLIC HEALTH RELEVANCE: Although the effectiveness of massage for overcoming muscle weakness following exercise is limited to a few high quality studies, Americans make more than 160 million visits annually to seek relief of musculoskeletal weakness and pain by manipulative or body-based practices. This basic science research is aimed at understanding the mechanisms of action of massage therapies to understand the basis of their effectiveness and to develop innovative strategies to maximize their clinical effectiveness.

描述（由申请人提供）：急性和慢性骨骼肌疼痛和无力是一般医疗实践中最常见的疾病之一。虽然用药物和传统的运动疗法治疗肌肉无力和疼痛取得了一些成功，但大量的人转向了其他方法，包括肌面松解、按摩、针灸和瑜伽。根据美国按摩治疗协会（AMTA，http://www.amtamassage.org），按摩对肌肉的好处包括：缓解肌肉紧张和僵硬，更快地愈合拉伤的肌肉和扭伤的韧带，减少肌肉疼痛，肿胀和痉挛，更大的运动范围，甚至提高运动成绩。虽然在这个时候有很多关于按摩的说法，但只有少数研究支持它的使用。此外，按摩工作的生物机制在很大程度上是未知的。为此，我们采用了我们完善的离心运动诱导的肌肉炎症和无力的体内兔模型，该模型非常模拟运动员的肌肉损伤，以检查按摩疗法的功效。初步研究表明，每天按摩四次（使用自行设计和制造的能够产生可重复负载的设备）可以使肌肉功能的恢复比对照组提高120%，同时减少组织炎症。我们的总体假设是，在按摩治疗期间以正确的幅度、持续时间和频率产生的生物力学信号是（i）通过抑制促炎介质的表达来抑制肌肉炎症的有效抗炎信号，以及（ii）通过上调对肌肉细胞增殖和分化必需的基因的表达来增强肌肉再生和修复的有效信号。将利用最先进的技术和分析方法研究三个目标，以确定按摩的最佳幅度，持续时间和频率，以恢复肌肉功能（峰值等长扭矩），同时研究这种组合对宿主炎症和再生及修复反应的影响。这种多学科的努力将有望为未来的机制研究和最终的临床试验提供强有力的理由，调查按摩疗法的最佳适应症和策略，以恢复骨骼肌功能障碍和改善整体人类健康。公共卫生关系：虽然按摩对克服运动后肌肉无力的有效性仅限于少数高质量的研究，但美国人每年有超过1.6亿人次通过按摩或身体练习来寻求缓解肌肉骨骼无力和疼痛。这项基础科学研究旨在了解按摩疗法的作用机制，以了解其有效性的基础，并制定创新策略，以最大限度地提高其临床效果。