Structure and Function of Integral Membrane Enzyme Human Aromatase

人芳香酶整合膜酶的结构与功能

• 批准号: 8189257
• 负责人: DEBASHIS GHOSH
• 金额: $ 19.47万
• 依托单位: UPSTATE MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8189257
• 关键词: 15q21.1; Active Sites; Adverse effects; Affinity; Amino Acids; Aminoglutethimide; Anabolism; Androgens; Androstenedione; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Binding; Biochemical; CYP19A1 gene; Catalysis; Chromosomes; Collaborations; Complex; Crystallization; Cytochrome P450; Cytochromes; Data; Data Set; Databases; Docking; Dose; Electron Transport; Endoplasmic Reticulum; Enzymes; Estradiol; Estriol; Estrogens; Estrone; Exemestane; Fadrozole; Flavoproteins; Formestane; Future; Genes; Goals; Hemeproteins; Hormones; Human; Human body; Hydrophobicity; In Situ; Investigation; Laboratories; Lead; Length; Letrozole; Ligands; Lipid Bilayers; Membrane; Methods; Molecular; Molecular Structure; Monitor; NADP; NADPH-Ferrihemoprotein Reductase; Nature; Oxidation-Reduction; Oxidoreductase; Pathway interactions; Placenta; Predisposition; Process; Property; Proteins; Reaction; Recombinants; Reporting; Research; Resolution; Roentgen Rays; Role; Solutions; Specificity; Structure; Structure-Activity Relationship; Substrate Specificity; Temperature; Testing; Testosterone; Work; anastrozole; base; design; effective therapy; enzyme mechanism; enzyme substrate complex; hormone therapy; improved; inhibitor/antagonist; malignant breast neoplasm; member; methyl group; novel; prevent; public health relevance; research study