RATIONAL DESIGN OF SELECTIVE ESTROGEN ENZYME MODULATORS

选择性雌激素酶调节剂的合理设计

• 批准号: 7181025
• 负责人: DEBASHIS GHOSH
• 金额: $ 1.17万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7181025
• 关键词: biomedical resource; structural biology

DESCRIPTION (provided by applicant): MacCHESS, a synchrotron radiation Research Resource for macromolecular crystallography, has the overall goal of advancing the frontiers of structural biology through innovative technical research and development and user support. MacCHESS leverages the National Science Foundation investments in the Cornell High Energy Synchrotron Source (CHESS), which maintains the synchrotron radiation laboratory, and the Laboratory for Elementary Particle Physics (LEPP), which operates the storage ring. MacCHESS technical developments are driven by both Core and Collaborative research projects involving a broad range of macromolecules. In addition to performing technical R&D and Core research, MacCHESS provides specialized instrumentation for macromolecular crystallography and a staff for user training and support. MacCHESS has established itself as one of the most productive facilities in the world for macromolecular crystallography, with almost 437 papers published during the past five years as a result of MacCHESS related technical research and development, Core and Collaborative research and Service. More than 72 of these papers were published in the high visibility journals, Science, the Nature journals, and Cell. Three CHESS stations, A-1, F-1 and F-2, are used for macromolecular crystallography experiments. During the next five years, MacCHESS technical R&D will focus on (1) microcrystallography, (2) membrane protein crystallography, (3) large unit cell structures, (4) ultrahigh resolution diffraction, (5) high throughput crystallography, (6) crystallographic software and phasing techniques and (7) crystallographic beamline hardware development. Each of these technical R&D efforts is driven by the challenging problems presented by collaborating investigators who study the atomic structure of molecules and complexes of great current interest to medicine and biology, including membrane proteins, regulatory protein complexes, nucleic acid/protein complexes, protein drug interactions and viruses. Technical developments resulting from MacCHESS research are freely available to the scientific community and disseminated through meetings, workshops, publications, web distributions and collaborations with other synchrotron sources.

描述(由申请人提供)：MacCHESS是一家用于大分子结晶学的同步辐射研究资源，其总体目标是通过创新的技术研究和开发以及用户支持来推进结构生物学的前沿。MacCHESS利用国家科学基金会对康奈尔高能同步加速器源(CHESS)和基本粒子物理实验室(LEPP)的投资，CHESS负责维护同步辐射实验室，LEPP负责运营存储环。MacCHESS的技术开发是由涉及广泛的大分子的核心和协作研究项目共同推动的。除了进行技术研发和核心研究外，MacCHESS还提供用于大分子结晶学的专业仪器，以及一支用户培训和支持人员。MacCHESS已经成为世界上最具生产力的大分子结晶学设施之一，在过去五年中发表了近437篇论文，这些论文是MacCHESS相关技术研究和开发、核心和合作研究和服务的结果。其中超过72篇论文发表在高知名度期刊、《科学》、《自然》期刊和《细胞》杂志上。用A-1、F-1和F-2三个棋台进行大分子结晶学实验。在接下来的五年里，MacCHESS的技术研发将集中在(1)微晶学，(2)膜蛋白结晶学，(3)大单胞结构，(4)超高分辨率衍射，(5)高通量结晶学，(6)结晶学软件和定相技术，(7)晶体光束线硬件开发。这些技术研发工作中的每一项都是由合作研究人员提出的挑战性问题推动的，他们研究目前对医学和生物学非常感兴趣的分子和复合体的原子结构，包括膜蛋白、调节蛋白复合体、核酸/蛋白质复合体、蛋白质药物相互作用和病毒。由MacCHESS研究产生的技术发展向科学界免费提供，并通过会议、讲习班、出版物、网络分发和与其他同步加速器来源的合作进行传播。