Development of antibody-based diagnostic assays for filoviruses

开发基于抗体的丝状病毒诊断方法

• 批准号: 8377064
• 负责人: GEORGE Georgiou GEORGIOU
• 金额: $ 26.08万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8377064
• 关键词: Address; Antibodies; Arkansas; Bacteria; Basic Science; Biological Assay; Categories; Communicable Diseases; Consultations; Development; Diagnostic; Disease; Educational workshop; Emerging Communicable Diseases; Ensure; Evaluation; Filovirus; Funding; Goals; Grant; Infectious Diseases Research; Infrastructure Activities; Institution; Knowledge; Laboratories; Legal patent; Louisiana; Medical; Mission; New Mexico; Oklahoma; Organism; Primates; Process; Progress Reports; RNA Viruses; Research; Research Activity; Research Personnel; Research Project Grants; Science; Scientist; Site Visit; Source; Staging; Sum; Texas; Therapeutic Agents; Translating; Translational Research; Universities; Veterinary Schools; Virus Diseases; base; biodefense; meetings; product development; programs; stem; success; therapeutic vaccine; vaccine development

The mission of the Western Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (WRCE) is the creation of synergistic,.multifaceted research, strong infrastructure, and activities to develop vaccines, therapeutics, and diagnostics against natural and manmade emerging infectious disease threats by applying the best basic and translational science. Scientists from 22 institutions propose to conduct 15 major research projects and provide six supportive core activities. The WRCE is a unifying force in Texas, New Mexico, Oklahoma, Arkansas, and Louisiana for collaborative research on infectious diseases. The evaluation of the national RCE program revealed that the WRCE was the top performer in the number of new investigators in biodefense, number of projects, number of organisms studied, number of patents filed, and number of new projects supported by other funds that stemmed from RCE projects. Successful basic scientists with substantial expertise in Category A-C agents have truly embraced the unfamiliar goal of translational product-oriented research. The 15 major projects address four themes: development of therapeutic agents for RNA viruses, platforms for multiplexed diagnostics for Category A-C agents and emerging agents, vaccine development for arboviral and emerging viral diseases, and vaccine development for diseases caused by intracellular bacteria. The 15 projects are currently pursuing new specific aims; this is a result of the WRCE's strategy in the previous grant cycle to support developmentaltype grants to initiate next-stage projects, and an early competition for major projects one year before the completion of the cycle. This planning process allowed selection of the best, most relevant science and development of synergistic interactions within the themes. Attentive guidance by the administrative core's analysis of progress reports, site visits, regional meetings, workshops, and formal external product development consultations support research activities, along with monthly theme meetings to ensure the continued success of projects. Highly productive scientists utilize such regional sources as three national primate research centers, 19 institutions with BSL-3 laboratories, two institutions with BSL-4 laboratories, two vaccine development centers, two DOE national laboratories, 13 participating medical universities, three participating veterinary schools, and four institutions with aerobiology expertise to translate their outstanding scientific knowledge into program that delivers more than the sum of its parts.

西部地区生物防御和新发传染病卓越中心的使命 研究（WRCE）是创造协同，多方面的研究，强大的基础设施和活动， 开发针对自然和人为新发传染病的疫苗、疗法和诊断方法 通过应用最好的基础科学和转化科学来应对威胁。来自22个机构的科学家建议， 开展15项主要研究项目，并提供6项支持性核心活动。WRCE是一个团结的力量 在得克萨斯州、新墨西哥州、俄克拉荷马州、阿肯色州和路易斯安那州， 疾病对国家农村经济合作计划的评估表明，农村经济合作计划是2000年以来表现最好的计划。 生物防御领域新的研究人员人数、项目数量、研究的生物体数量、 申请的专利，以及由来自RCE项目的其他基金支持的新项目数量。 在A-C类药剂方面具有丰富专业知识的成功基础科学家真正接受了 翻译产品导向研究的陌生目标。15个主要项目涉及四个主题： 开发RNA病毒治疗剂，A-C类多重诊断平台 病原体和新兴病原体，虫媒病毒和新兴病毒性疾病的疫苗开发，以及疫苗 细胞内细菌引起的疾病的发展。这15个项目目前正在寻求新的 具体目标;这是WRCE在上一个赠款周期中支持发展型项目的战略的结果 赠款以开展下一阶段的项目，并在重大项目的一年前提前进行竞争。 循环的完成。这一规划过程允许选择最好的，最相关的科学和 在各主题内开展协同互动。行政核心的悉心指导 进度报告分析、现场访问、区域会议、研讨会和正式外部产品 发展磋商支持研究活动，沿着每月的主题会议，以确保 项目的持续成功。高生产力的科学家利用这些区域来源，如三个国家 灵长类动物研究中心，19个机构拥有BSL-3实验室，2个机构拥有BSL-4实验室， 两个疫苗开发中心，两个能源部国家实验室，13所参与的医科大学，三个 参与的兽医学校和四个具有空气生物学专业知识的机构， 将科学知识转化为程序，提供比其部分总和更多的内容。