Development of antibody-based diagnostic assays for filoviruses

西部地区生物防御和新发传染病卓越中心的使命 研究(WRCE)是创建协同的、多方面的研究、强大的基础设施和活动，以 开发针对自然和人为新发传染病的疫苗、疗法和诊断方法 通过应用最好的基础科学和翻译科学来进行威胁。来自22个机构的科学家提议 实施15个重大研究项目，提供6项支持性核心活动。WRCE是一股团结的力量 在德克萨斯州、新墨西哥州、俄克拉何马州、阿肯色州和路易斯安那州合作研究传染病 疾病。对国家RCE项目的评估显示，WRCE是 生物防御方面的新调查人员数目、项目数目、研究的生物体数目、 申请的专利，以及由RCE项目产生的其他基金支持的新项目的数量。 成功的基础科学家在A-C类特工方面拥有丰富的专业知识，他们真正接受了 翻译产品导向研究的陌生目标。15个主要项目涉及四个主题： 用于A-C类多重诊断的RNA病毒治疗试剂的开发 药物和新兴药物，虫媒病毒和新出现的病毒疾病的疫苗开发，以及疫苗 细胞内细菌引起的疾病的研究进展。这15个项目目前正在寻求新的 具体目标；这是WRCE在前一个赠款周期中支持发展类型的战略的结果 拨款启动下一阶段的项目，并在一年前为主要项目进行早期竞争 周期的完成。这一规划过程允许选择最好、最相关的科学和 在主题范围内发展协同互动。行政核心的用心指导 分析进度报告、现场访问、区域会议、研讨会和正式外部产品 发展协商支持研究活动，并每月举行主题会议，以确保 项目持续取得成功。高生产率的科学家利用区域资源，如三个国家 灵长类研究中心，19个拥有BSL-3实验室的机构，2个拥有BSL-4实验室的机构， 两个疫苗开发中心，两个能源部国家实验室，13所参与的医科大学，3所 参与的兽医学校，以及四个具有空气生物学专业知识的机构，将他们杰出的 将科学知识转化为计划，提供的不仅仅是各个部分的总和。

The mission of the Western Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (WRCE) is the creation of synergistic,.multifaceted research, strong infrastructure, and activities to develop vaccines, therapeutics, and diagnostics against natural and manmade emerging infectious disease threats by applying the best basic and translational science. Scientists from 22 institutions propose to conduct 15 major research projects and provide six supportive core activities. The WRCE is a unifying force in Texas, New Mexico, Oklahoma, Arkansas, and Louisiana for collaborative research on infectious diseases. The evaluation of the national RCE program revealed that the WRCE was the top performer in the number of new investigators in biodefense, number of projects, number of organisms studied, number of patents filed, and number of new projects supported by other funds that stemmed from RCE projects. Successful basic scientists with substantial expertise in Category A-C agents have truly embraced the unfamiliar goal of translational product-oriented research. The 15 major projects address four themes: development of therapeutic agents for RNA viruses, platforms for multiplexed diagnostics for Category A-C agents and emerging agents, vaccine development for arboviral and emerging viral diseases, and vaccine development for diseases caused by intracellular bacteria. The 15 projects are currently pursuing new specific aims; this is a result of the WRCE's strategy in the previous grant cycle to support developmentaltype grants to initiate next-stage projects, and an early competition for major projects one year before the completion of the cycle. This planning process allowed selection of the best, most relevant science and development of synergistic interactions within the themes. Attentive guidance by the administrative core's analysis of progress reports, site visits, regional meetings, workshops, and formal external product development consultations support research activities, along with monthly theme meetings to ensure the continued success of projects. Highly productive scientists utilize such regional sources as three national primate research centers, 19 institutions with BSL-3 laboratories, two institutions with BSL-4 laboratories, two vaccine development centers, two DOE national laboratories, 13 participating medical universities, three participating veterinary schools, and four institutions with aerobiology expertise to translate their outstanding scientific knowledge into program that delivers more than the sum of its parts.