Circadian Constrained Schedule Optimization for Maximal Performance

昼夜节律约束时间表优化以获得最大性能

基本信息

  • 批准号:
    8005949
  • 负责人:
  • 金额:
    $ 1.23万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-01-18 至 2011-05-28
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The use of mathematical models to design sleep-wake and countermeasure schedules for improved performance is proposed. Travel across multiple time zones results in desynchronization of environmental time cues and the sleep-wake schedule from their normal phase relationships with the endogenous circadian system. Circadian misalignment can result in poor neurobehavioral performance, decreased sleep efficiency, and inappropriately timed physiological signals including gastrointestinal activity and hormone release. Frequent and repeated transmeridian travel is associated with long-term cognitive deficits, and rodents experimentally exposed to repeated schedule shifts have increased death rates. One approach to reduce the short-term circadian, sleep-wake, and performance problems is to use mathematical models of the circadian pacemaker to design countermeasures that rapidly shift the circadian pacemaker to align with the new schedule. The approach includes "cutting-edge" mathematical and computer science methods for designing interventions that combine an algorithm for optimal placement of countermeasures with a novel mode of schedule representation. Our preliminary results demonstrate that rapid circadian resynchrony and the resulting improvement in neurobehavioral performance can be quickly achieved even after moderate to large shifts in the sleep-wake schedule. The key schedule design inputs are endogenous circadian period length, desired sleep-wake schedule, length of intervention, background light level, and countermeasure strength. A new schedule representation is proposed as a mechanism that facilitates schedule design, simulation studies, and experiment design to significantly decrease the amount of time to design an appropriate intervention. The proposed methods have direct implications for designing jet lag, shift-work, and non-24-hour schedules, including scheduling for extreme environments, such as in space, undersea, or in polar-regions. The proposed research meets several objectives of the National Institute of General Medical Sciences including the use of bioinformatics and computational biology to determine interventions that alleviate the effects of jetlag and shift-work on multiple-organ systems including behavior. The proposed training aims to integrate mathematical, computational, and circadian/sleep research methods into a common framework and meets the aim of NIGMS to train well-prepared scientists at the interface of different fields. PUBLIC HEALTH RELEVANCE: This work could affect the millions of people yearly who must work and sleep at time at which their circadian system is promoting the opposite behavior: this includes people experiencing jet lag or who must work night or rotating shifts. This desynchrony between internal circadian clock time and external environmental time affects 5 billion passengers who travel by air yearly, and 20% of global industrial employees who are shift workers, including 4.5 million international transport workers, and 1.4 million US military personnel who are often expected to work optimally despite changes in their schedule. The ultimate goal of this research is to make a set of mathematical, computational, and software tools that allow knowledge derived from circadian and sleep research to be used by non-professionals.
描述(由申请人提供):提出了使用数学模型来设计睡眠-唤醒和对策时间表以改善性能。跨多个时区的旅行导致环境时间线索和睡眠-觉醒时间表与内源性昼夜节律系统的正常相位关系的去同步化。昼夜节律失调会导致神经行为表现不佳,睡眠效率降低,以及不适当的生理信号,包括胃肠活动和激素释放。频繁和重复的跨子午线旅行与长期的认知缺陷有关,啮齿动物实验暴露于重复的时间表变化增加了死亡率。减少短期昼夜节律、睡眠-觉醒和性能问题的一种方法是使用昼夜节律起搏器的数学模型来设计对策,该对策快速改变昼夜节律起搏器以与新的时间表一致。该方法包括“尖端”的数学和计算机科学的方法来设计干预措施,结合联合收割机的算法,以最佳的时间表表示的一种新的模式放置的对策。我们的初步研究结果表明,快速昼夜节律和由此产生的改善神经行为的表现,可以迅速实现,即使在中度到大的变化,在睡眠-觉醒时间表。关键的时间表设计输入是内源性昼夜节律周期长度、期望的睡眠-觉醒时间表、干预长度、背景光水平和对策强度。提出了一种新的时间表表示作为一种机制,有利于时间表设计,模拟研究和实验设计,以显着减少的时间量来设计一个适当的干预。所提出的方法对设计时差、轮班工作和非24小时时间表有直接影响,包括极端环境下的时间表,如太空、海底或极地地区。拟议的研究符合国家普通医学科学研究所的几个目标,包括使用生物信息学和计算生物学来确定减轻时差和轮班工作对多器官系统(包括行为)影响的干预措施。拟议的培训旨在将数学,计算和昼夜节律/睡眠研究方法整合到一个共同的框架中,并满足NIGMS在不同领域的界面上培养准备充分的科学家的目标。 公共卫生相关性:这项工作可能会影响每年数百万人,他们必须在他们的昼夜节律系统促进相反行为的时间工作和睡眠:这包括经历时差反应或必须夜班或轮班的人。内部生物钟时间和外部环境时间之间的这种差异影响了每年50亿乘飞机旅行的乘客,以及全球20%的轮班工人,包括450万国际运输工人和140万美国军事人员,尽管他们的时间表发生了变化,但他们通常被期望以最佳方式工作。这项研究的最终目标是制作一套数学,计算和软件工具,允许非专业人员使用来自昼夜节律和睡眠研究的知识。

项目成果

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