DETERMINING THE PATHWAY OF NASCENT-PROTEIN INSERTION THROUGH THE PROTEIN-CONDUC
DETERMINING THE PATHWAY OF NASCENT-PROTEIN INSERTION THROUGH THE PROTEIN-CONDUC
批准号:
8364332
负责人:
Klaus Schulten
金额:
$0.11万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-09-15 至 2013-07-31
关键词:
BindingBiomedical ResearchCollaborationsElectronsExcretory functionFundingGrantHigh Performance ComputingIon ChannelLateralMembraneNational Center for Research ResourcesPathway interactionsPrincipal InvestigatorProteinsResearchResearch InfrastructureResourcesRibosomesSimulateSourceStructureUnited States National Institutes of Healthcost
中文摘要
这个子项目是利用这些资源的众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
For nascent proteins destined for excretion or membrane insertion, synthesis by the ribosome is concomitant with their insertion into a protein-conducting membrane channel, SecY, which translocates a protein across or inserts it into the membrane. In collaboration with cryo-electron microscopists we determined an all-atom structure of a ribosome-SecY-nascent-protein intermediate that permits one to investigate the membrane insertion pathway. We seek to simulate the membrane-SecY-nascent protein part of our structure to determine how the intermediate revealed, an orientationally inverted N-terminus binding outside a SecY lateral gate, arises from forces due to protein elongation.
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专著(0)
科研奖励(0)
会议论文
Hands-on Workshops on Computational Biophysics
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批准号:8414721
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项目类别:
-
资助金额:$16.45万
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财政年份:2013
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负责人:Klaus Schulten
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依托单位:
Hands-on Workshops on Computational Biophysics
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批准号:8744293
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项目类别:
-
资助金额:$13.97万
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财政年份:2013
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负责人:Klaus Schulten
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依托单位:
SERVICE
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批准号:8363651
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项目类别:
-
资助金额:$9.95万
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财政年份:2011
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负责人:Klaus Schulten
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依托单位:
TRAINING
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批准号:8363646
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项目类别:
-
资助金额:$9.95万
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财政年份:2011
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负责人:Klaus Schulten
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依托单位:
SIMULATIONS OF SUPRAMOLECULAR BIOLOGICAL STRUCTURES
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批准号:8364241
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项目类别:
-
资助金额:$0.11万
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财政年份:2011
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负责人:Klaus Schulten
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依托单位:
Commodity Hardware Acceleration of Popular Modeling Software for Structural Biolo
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批准号:8300818
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项目类别:
-
资助金额:$28.96万
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财政年份:2011
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负责人:Klaus Schulten
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依托单位:
Commodity Hardware Acceleration of Popular Modeling Software for Structural Biolo
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批准号:8657059
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项目类别:
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资助金额:$29.36万
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财政年份:2011
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负责人:Klaus Schulten
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依托单位:
Commodity Hardware Acceleration of Popular Modeling Software for Structural Biolo
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批准号:8147612
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项目类别:
-
资助金额:$28.98万
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财政年份:2011
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负责人:Klaus Schulten
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依托单位:
Commodity Hardware Acceleration of Popular Modeling Software for Structural Biolo
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批准号:8465244
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项目类别:
-
资助金额:$28.35万
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财政年份:2011
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负责人:Klaus Schulten
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依托单位:
SIMULATIONS OF SUPRAMOLECULAR BIOLOGICAL STRUCTURES
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批准号:8171819
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项目类别:
-
资助金额:$0.11万
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财政年份:2010
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负责人:Klaus Schulten
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依托单位:
MARVEL BIOMED/NIH GRANT
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批准号:8171826
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项目类别:
-
资助金额:$0.11万
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财政年份:2010
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负责人:Klaus Schulten
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依托单位:
Petascale Molecular Dynamics Data Processing System
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批准号:7795458
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项目类别:
-
资助金额:$48.85万
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财政年份:2010
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负责人:Klaus Schulten
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依托单位:
TRAINING
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批准号:8172029
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项目类别:
-
资助金额:$10.05万
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财政年份:2010
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负责人:Klaus Schulten
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依托单位:
SERVICE
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批准号:8172036
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项目类别:
-
资助金额:$10.05万
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财政年份:2010
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负责人:Klaus Schulten
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依托单位:
SERVICE
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批准号:7955609
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项目类别:
-
资助金额:$11.5万
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财政年份:2009
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负责人:Klaus Schulten
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依托单位:
SIMULATIONS OF SUPRAMOLECULAR BIOLOGICAL STRUCTURES
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批准号:7956072
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项目类别:
-
资助金额:$0.09万
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财政年份:2009
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负责人:Klaus Schulten
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依托单位:
TRAINING
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批准号:7955601
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项目类别:
-
资助金额:$11.5万
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财政年份:2009
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负责人:Klaus Schulten
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依托单位:
MARVEL BIOMED/NIH GRANT
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批准号:7956086
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项目类别:
-
资助金额:$0.09万
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财政年份:2009
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负责人:Klaus Schulten
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依托单位:
SIMULATIONS OF SUPRAMOLECULAR BIOLOGICAL STRUCTURES
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批准号:7723112
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项目类别:
-
资助金额:$0.05万
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财政年份:2008
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负责人:Klaus Schulten
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依托单位:
TRAINING
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批准号:7723594
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项目类别:
-
资助金额:$9.47万
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财政年份:2008
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负责人:Klaus Schulten
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依托单位:
海外基金