INTRODUCTION TO BIOINFORMATICS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和子项目主要研究者的主要支持可能由其他来源提供，包括其他NIH来源。 为子项目列出的总成本可能代表子项目使用的中心基础设施的估计数量，而不是NCRR赠款向子项目或子项目工作人员提供的直接资金。 目录描述生物信息学是用计算机分析分子生物学数据的方法的集合。来自不同学科（化学，生物学，数学，计算机科学和研究）的兰斯顿大学教师团队将教授这门课程，目标是培养研究型少数民族学生从事生物信息学职业。有兴趣的学生可以在PSC竞争暑期实习机会。 生物信息学是人类基因组计划和万维网出现后不久发展起来的一个研究领域。一旦聚合酶链式反应和DNA测序仪等专利技术被开发出来，分子生物学家就开始对整个基因组进行测序，从人类、大鼠和小鼠到植物（如水稻和拟南芥），再到微生物（如大肠杆菌）。coli和Bacillus subtilis。这位科学家很快意识到，需要有人提供工具来收集、存储和分析这些呈指数增长的核苷酸序列。计算机科学家需要编写脚本，以允许整个基因组的组装和基因组内和基因组之间的基因比较（大鼠与人类与蚊子）。计算机科学家很快意识到，需要数学家来处理统计、算法和矩阵的复杂细节。生物信息学是一个多学科领域，不断发展，以满足后基因组领域的需求，如果有一个，目标是个性化医疗的减少领域。 学生应该：1。定义生物信息学并了解这门学科是如何发展的。2.完成Unix操作系统实践练习. 3.从数据库中提取序列并完成实际操作练习. 4.完成数据库搜索和对齐操作练习。5.完成多序列比对动手练习。6.完成模式识别和匹配实践练习。7.完成Python练习。8.完成系统发育分析实践练习。9.完成在序列组中查找特征的动手练习。 本课程将由一组在各自研究领域有经验的教师授课。教师将使用实践练习，powerpoint演示文稿，并在介绍他们的信息期刊文章。课程要求每个学生应该：1。准时上课。2.完成所有的动手练习。参加所有考试或测验。3.完成您的项目。4.介绍你的项目。评估方法-课程要求的分数每个教师将评估学生作为主题本身。最低成绩要求：A = 90%; B = 80%; C = 70%; D = 60%; F = 59%以下3.上课出勤率学生必须参加所有的讲座和实验。每次会议所涉及的材料都是至关重要的，是后续材料的先决条件。一堂课中遗漏的材料会严重影响学生理解相关材料的能力。上课开始时会传阅一份出勤表。每天都会上课。如果没有安排实验作业，那么课程将在复习课上进行。六（6）缺席可能导致行政撤回。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. CATALOG DESCRIPTION Bioinformatics is a collection of methods used for analyzing molecular biology data with a computer. A team of Langston University faculty from various disciplines (chemistry, biology, mathematics, computer science, and research) will teach this course with the goal of cultivating research-oriented minority students for careers in bioinformatics. Interested students can compete for summer internships at PSC. RATIONALE Bioinformatics is an area of research developing as a result of the Human Genome Initiative and the advent of the World Wide Web, shortly thereafter. Once patented technology such as the polymerase chain reaction and the DNA sequencer were developed, molecular biologist began sequencing entire genomes from human, rat, and mouse to plants, such as rice and Arabidopsis, to microorganisms such as E. coli and Bacillus subtilis. The scientist quickly realized that someone needed to provide tools for collection, storage, and analysis of this exponentially growing amount of nucleotide sequences. Computer scientist were needed to write scripts to allow for the assembly of entire genomes and comparison of genes within the genomes and between genomes (rat with human with mosquitos. Computer scientist quickly realized that mathematicians were needed for the intricate details of statistics, algorithms, and matrices. Bioinformatics is a multi-disciplinary field that is constantly evolving to meet the demands of the post-genomic area, if there is one, aiming for the diminishless field of personalized medicine. COURSE OBJECTIVES The student should: 1. Define Bioinformatics and understand how this discipline evolved. 2. Complete the Unix Operating System Hands- On Exercise. 3. Retrieve Sequences from Databases and Complete Hands- On Exercise. 4. Complete the Database Searching and Alignment Hands-On Exercise. 5. Complete the Multiple Sequence Alignment Hands-On Exercise. 6. Complete the Pattern Identification and Matching Hands-On Exercise. 7. Complete the Python Exercises. 8. Complete the Phylogenetic Analysis Hands-On Exercises. 9. Complete the Finding Features in Groups of Sequences Hands-On Exercises. METHOD OF INSTRUCTION This class will be taught by a team of faculty who have experience in their fields of research. The faculty will use hands-on exercises, powerpoint presentations, and journal articles when presenting their information. COURSE REQUIREMENTS Each student should: 1. Attend all classes, punctually. 2. Complete all hands-on exercises. Take all exams or quizzes. 3. Complete your project. 4. Present your project. METHOD OF EVALUATION- Points for course requirements Each faculty member will assess the students as the subject matter lends itself. Minimum Grade Requirement: A = 90%; B = 80%; C = 70%; D = 60%; F = below 59% 3. Class Attendance It is imperative that students attend all lectures and labs. Material covered during each session is critical and is prerequisite to subsequent material. Material missed in one lecture can seriously hinder the student(s ability to comprehend related material. An attendance sheet will circulate at the beginning of class. Classes will be held daily. If no laboratory assignments are scheduled, then classes will be held in the recitation room. Six (6) absentees can result in an administrative withdrawal.