P30- Core Grant for Vision Research

申请者描述(由申请者提供)：申请继续资助埃默里大学眼科NEI核心中心基金。核心中心奖助金续期申请包括三个模块：(1)结构生物学和成像，(2)功能基因组学和蛋白质组学，以及(3)生物信息学和生物统计学。过去的核心中心赠款成功地利用了对协作视觉研究和服务的支持，涉及32名教职员工(包括21名由NEI资助的首席研究员)、16名博士后研究员、6名博士后研究员，并在过去5年中发表了250多篇论文。结构生物学和成像模块将免疫组织化学、体内和体外共聚焦显微镜、荧光图像分析、Vivio荧光光度和磁共振图像添加到光学和电子显微镜服务中。功能基因组学和蛋白质组学模块为合成寡核苷酸、蛋白质序列、聚合酶链式反应、基因表达激光显微捕获和流式细胞术提供服务。生物信息学和生物统计模块将在高级计算分析和生物信息学资源中提供综合生物统计学、生物信息学和数据管理。核心模块已经并将继续提高我们的研究效率，提供共同的集中服务，以刺激和促进教职员工之间的合作研究，并吸引其他大学学科参与VISION研究。这一核心设施也是亚特兰大的中央视力研究设施，来自埃默里大学、耶克斯地区灵长类中心、佐治亚理工学院、佐治亚州立大学、莫尔豪斯医学院、退伍军人管理局医疗中心和疾病控制和预防中心的教职员工可以在这里开展视力研究方面的合作研究。核心设施还在我们的部门NEI培训补助金(T32 EY007092-19)支持的博士后和博士后研究员的研究项目中发挥作用，该补助金最近续签了未来五年(2004-2009)。

DESCRIPTION (provided by applicant): Continued support is requested for the NEI Core Center Grant in the Department of Ophthalmology at Emory University. This Core Center Grant renewal application includes three Modules: (1) Structural Biology and Imaging, (2) Functional Genomics and Proteomics, and (3) Bioinformatics and Biostatistics. The past Core Center grant has successfully utilized supporting collaborative vision research and service involving 32 faculty (including more than 21 NEI funded principal investigators), 16 postdoctoral fellows, six predoctoral fellows and generating over 250 publications over the past five years. The Structural Biology and Imaging Module adds immunohistochemistry, in vivo and in vitro confocal microscopy, fluoresence image analysis, in vivio flurophotomery and magnetic resonance image to the light and electron microscopy services. The Functional Genomics and Proteomics module provides services for synthetic oligonucleotides, protein sequences, PCR, laser microcapture with gene expression and flow cytometry. The Bioinformatics and Biostatistics Module will provide integrated biostatistics, bioinformatics and data management in advanced computational analysis and bioinformatics resources. The Core Modules have and will continue to enhance our research productivity by providing common centralized services to stimulate and facilitate collaborative studies between faculty an to attract other university disciplines to vision research. This Core facility also serves as a centralized vision research facility in Atlanta where faculty from Emory University, Yerkes Regional Primate Center, Georgia Institute of Technology, Georgia State University, Morehouse School of Medicine, The Veterans Administration Medical Center and the Centers for Disease Control and Prevention can undertake collaborative studies in vision research. The Core facilities also serve a role in the research projects of our pre- and postdoctoral fellows supported by our departmental NEI Training Grant (T32 EY007092-19), recently renewed for the next five years (2004-2009).